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Select item 76708791.

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients

Silvia Jiménez-Morales, Juan Luis Jiménez-Ruíz, Blanca Estela Del Río-Navarro, Efraín Navarro-Olivos, Guillermo Escamilla-Guerrero, Ram Savan, Michael Dean, Lorena Orozco

Mol Biol Rep. Author manuscript; available in PMC 2020 Nov 17.

Published in final edited form as: Mol Biol Rep. 2014; 41(4): 2109–2117. Published online 2014 Jan 16. doi: 10.1007/s11033-014-3060-6

PMCID:: PMC7670879

Abstract Article PDF–468K

Select item 74280762.

Muscarinic receptors promote castration resistant growth of prostate cancer through a FAK-YAP signaling axis

Yusuke Goto, Toshinori Ando, Hiroki Izumi, Xiaodong Feng, Nadia Arang, Mara Gilardi, Zhiyong Wang, Kazuyo Ando, J. Silvio Gutkind

Oncogene. Author manuscript; available in PMC 2020 Sep 23.

Published in final edited form as: Oncogene. 2020 May; 39(20): 4014–4027. Published online 2020 Mar 23. doi: 10.1038/s41388-020-1272-x

PMCID:: PMC7428076

Abstract Article PDF–1.0M

Select item 62192933.

Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling

Qing-Qing Yin, Lin-Hui Xu, Mi Zhang, Chen Xu

Asian J Androl. 2018 Nov-Dec; 20(6): 608–614. Published online 2018 Jul 13. doi: 10.4103/aja.aja_55_18

PMCID:: PMC6219293

Abstract Article PDF–2.9M

Select item 51595024.

Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K⁺ Channels as Downstream Effectors of G_q Protein-coupled Receptors

Marie-Cécile Kienitz, Dilyana Vladimirova, Christian Müller, Lutz Pott, Andreas Rinne

J Biol Chem. 2016 Dec 16; 291(51): 26410–26426. Published online 2016 Nov 10. doi: 10.1074/jbc.M116.746974

PMCID:: PMC5159502

Abstract Article PDF–1.3M

Select item 49153875.

Crystal Structures of the M₁ and M₄ Muscarinic Acetylcholine Receptors

David M. Thal, Bingfa Sun, Dan Feng, Vindhya Nawaratne, Katie Leach, Christian C. Felder, Mark G. Bures, David A. Evans, William I. Weis, Priti Bachhawat, Tong Sun Kobilka, Patrick M. Sexton, Brian K. Kobilka, Arthur Christopoulos

Nature. Author manuscript; available in PMC 2016 Sep 17.

Published in final edited form as: Nature. 2016 Mar 17; 531(7594): 335–340. Published online 2016 Mar 9. doi: 10.1038/nature17188

PMCID:: PMC4915387

Abstract Article PDF–1.9M

Select item 46302536.

Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors

Pavel Michal, Esam E. El-Fakahany, Vladimír Doležal

Neurochem Res. 2015; 40(10): 2068–2077. Published online 2014 May 13. doi: 10.1007/s11064-014-1325-z

PMCID:: PMC4630253

Abstract Article PDF–765K

Select item 42461207.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M₁ Muscarinic Acetylcholine Receptor

Alaa Abdul-Ridha, J. Robert Lane, Shailesh N. Mistry, Laura López, Patrick M. Sexton, Peter J. Scammells, Arthur Christopoulos, Meritxell Canals

J Biol Chem. 2014 Nov 28; 289(48): 33701–33711. Published online 2014 Oct 17. doi: 10.1074/jbc.M114.604967

PMCID:: PMC4246120

Abstract Article PDF–1.6M

Select item 41409398.

Allosteric Modulation of M₁ Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking

Holly R. Yeatman, J. Robert Lane, Kwok Ho Christopher Choy, Nevin A. Lambert, Patrick M. Sexton, Arthur Christopoulos, Meritxell Canals

J Biol Chem. 2014 May 30; 289(22): 15856–15866. Published online 2014 Apr 21. doi: 10.1074/jbc.M113.536672

PMCID:: PMC4140939

Abstract Article PDF–1.3M

Select item 39376739.

Molecular Determinants of Allosteric Modulation at the M₁ Muscarinic Acetylcholine Receptor

Alaa Abdul-Ridha, Laura López, Peter Keov, David M. Thal, Shailesh N. Mistry, Patrick M. Sexton, J. Robert Lane, Meritxell Canals, Arthur Christopoulos

J Biol Chem. 2014 Feb 28; 289(9): 6067–6079. Published online 2014 Jan 17. doi: 10.1074/jbc.M113.539080

PMCID:: PMC3937673

Abstract Article PDF–2.1M

Select item 363371710.

Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease

Junghee Lee, Yu Jin Hwang, Jong-Yeon Shin, Won-Chul Lee, Jinhong Wie, Ki Yoon Kim, Min Young Lee, Daehee Hwang, Rajiv R. Ratan, Ae Nim Pae, Neil W. Kowall, Insuk So, Jong-Il Kim, Hoon Ryu

Acta Neuropathol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Acta Neuropathol. 2013 May; 125(5): 727–739. Published online 2013 Mar 2. doi: 10.1007/s00401-013-1103-z

PMCID:: PMC3633717

Abstract Article PDF–4.1M

Select item 359473111.

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

E Scarr, J M Craig, M J Cairns, M S Seo, J C Galati, N J Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, A P Carroll, R Saffery, B Dean

Transl Psychiatry. 2013 Feb; 3(2): e230. Published online 2013 Feb 19. doi: 10.1038/tp.2013.3

PMCID:: PMC3594731

Abstract Article PDF–900K

Select item 358383012.

Autoantibodies against Muscarinic Receptors in Breast Cancer: Their Role in Tumor Angiogenesis

María Gabriela Lombardi, María Pía Negroni, Laura Tatiana Pelegrina, María Ester Castro, Gabriel L. Fiszman, María Eugenia Azar, Carlos Cresta Morgado, María Elena Sales

PLoS One. 2013; 8(2): e57572. Published online 2013 Feb 27. doi: 10.1371/journal.pone.0057572

PMCID:: PMC3583830

Abstract Article PDF–625K

Select item 353672713.

Modulation of distinct isoforms of L-type calcium channels by G_q-coupled receptors in Xenopus oocytes: Antagonistic effects of Gβγ and protein kinase C

Sharon Weiss, Tal Keren-Raifman, Shimrit Oz, Adva Ben-Mocha, Hannelore Haase, Nathan Dascal

Channels (Austin) 2012 Nov 1; 6(6): 426–437. doi: 10.4161/chan.22016

PMCID:: PMC3536727

Abstract Article PDF–2.0M

Select item 326584814.

Cdc14 Phosphatases Preferentially Dephosphorylate a Subset of Cyclin-dependent kinase (Cdk) Sites Containing Phosphoserine

Steven C. Bremmer, Hana Hall, Juan S. Martinez, Christie L. Eissler, Thomas H. Hinrichsen, Sandra Rossie, Laurie L. Parker, Mark C. Hall, Harry Charbonneau

J Biol Chem. 2012 Jan 13; 287(3): 1662–1669. Published online 2011 Nov 23. doi: 10.1074/jbc.M111.281105

PMCID:: PMC3265848

Abstract Article PDF–1.9M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317312716.

Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data: MT7 SNAKE TOXIN BOUND TO DIMERIC hM1 MUSCARINIC RECEPTOR

Catherine Marquer, Carole Fruchart-Gaillard, Guillaume Letellier, Elodie Marcon, Gilles Mourier, Sophie Zinn-Justin, André Ménez, Denis Servent, Bernard Gilquin

J Biol Chem. 2011 Sep 9; 286(36): 31661–31675. Published online 2011 Jun 17. doi: 10.1074/jbc.M111.261404