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Select item 110890901.

Cyclin‐dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration‐resistant prostate cancer

Haozhe Zhang, Yi Zhou, Yating Feng, Wenli Hou, Yafei Chen, Zengzhen Xing, Yifan Zhang, Qiang Wei, Yu Yin, Ju Guo, Hailiang Hu

Clin Transl Med. 2024 May; 14(5): e1678. Published online 2024 May 12. doi: 10.1002/ctm2.1678

PMCID:: PMC11089090

Abstract Article PDF–7.1M

Select item 109291892.

Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects

Yi-Lin Zhang, Tao-Tao Tang, Wei-Jie Ni, Zhong-Tang Li, Liang-Yun-Zi Jiang, Yao Wang, Xuan Zhou, Jing-Yuan Cao, Qing Yin, Wei Jiang, Ya-Jie Zhao, Wei-Hua Gan, Ai-Qing Zhang, Zuo-Lin Li, Yi Wen, Lin-Li Lv, Bi-Cheng Liu, Bin Wang

Int J Biol Sci. 2024; 20(5): 1669–1687. Published online 2024 Feb 12. doi: 10.7150/ijbs.90872

PMCID:: PMC10929189

Abstract Article PDF–16M

Select item 108002943.

ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features

Miriam Forster‐Sack, Martin Zoche, Bernhard Pestalozzi, Isabell Witzel, Esther Irene Schwarz, Joel Julien Herzig, Hisham Fansa, Christoph Tausch, Jeff Ross, Holger Moch, Zsuzsanna Varga

J Pathol Clin Res. 2024 Mar; 10(2): e12362. Published online 2024 Jan 21. doi: 10.1002/2056-4538.12362

PMCID:: PMC10800294

Abstract Article PDF–45M

Select item 107414044.

Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells

Trine V. Larsen, Christoffer T. Maansson, Tina F. Daugaard, Brage S. Andresen, Boe S. Sorensen, Anders L. Nielsen

Cells. 2023 Dec; 12(24): 2844. Published online 2023 Dec 15. doi: 10.3390/cells12242844

PMCID:: PMC10741404

Abstract Article PDF–1.6M

Select item 106536455.

SMG1 and CDK12 Link ΔNp63α Phosphorylation to RNA Surveillance in Keratinocytes

Casimir Bamberger, Sandra Pankow, John R. Yates, III

J Proteome Res. Author manuscript; available in PMC 2023 Nov 16.

Published in final edited form as: J Proteome Res. 2021 Dec 3; 20(12): 5347–5358. Published online 2021 Nov 11. doi: 10.1021/acs.jproteome.1c00427

PMCID:: PMC10653645

Abstract Article PDF–1.6M

Select item 106390666.

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Zhijia Wang, Samu V Himanen, Heidi M Haikala, Caroline C Friedel, Anniina Vihervaara, Matjaž Barborič

Nucleic Acids Res. 2023 Nov 10; 51(20): 10970–10991. Published online 2023 Oct 9. doi: 10.1093/nar/gkad792

PMCID:: PMC10639066

Abstract Article PDF–4.0M

Select item 105658767.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102879018.

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

Nucleic Acids Res. 2023 Jun 23; 51(11): 5512–5526. Published online 2023 Apr 7. doi: 10.1093/nar/gkad258

PMCID:: PMC10287901

Abstract Article PDF–3.4M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1019862910.

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Sci Adv. 2023 May; 9(20): eadf8698. Published online 2023 May 19. doi: 10.1126/sciadv.adf8698

PMCID:: PMC10198629

Abstract Article PDF–2.3M

Select item 1013893111.

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage

Sanna Abbasi, Laila Bayat, Caroline Schild-Poulter

Int J Mol Sci. 2023 Apr; 24(8): 7041. Published online 2023 Apr 11. doi: 10.3390/ijms24087041

PMCID:: PMC10138931

Abstract Article PDF–4.0M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 997863513.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 988113614.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 977255815.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969816.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 970808617.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 961787718.

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux

Nat Commun. 2022; 13: 6457. Published online 2022 Oct 29. doi: 10.1038/s41467-022-34179-8