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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 101516152.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 100103803.

Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression

Naoki Kimura, Ken-ichi Takayama, Yuta Yamada, Haruki Kume, Tetsuya Fujimura, Satoshi Inoue

Cancer Res Commun. 2022 Aug; 2(8): 870–883. Published online 2022 Aug 25. doi: 10.1158/2767-9764.CRC-22-0126

PMCID:: PMC10010380

Abstract Article PDF–16M

Select item 97974954.

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi

Commun Biol. 2022; 5: 1420. Published online 2022 Dec 28. doi: 10.1038/s42003-022-04369-7

PMCID:: PMC9797495

Abstract Article PDF–3.0M

Select item 97933595.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w

PMCID:: PMC9793359

Abstract Article PDF–3.7M

Select item 91357166.

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

Agnese Cristini, Michael Tellier, Flavia Constantinescu, Clelia Accalai, Laura Oana Albulescu, Robin Heiringhoff, Nicolas Bery, Olivier Sordet, Shona Murphy, Natalia Gromak

Nat Commun. 2022; 13: 2961. Published online 2022 May 26. doi: 10.1038/s41467-022-30604-0

PMCID:: PMC9135716

Abstract Article PDF–1.9M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 89454589.

Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?

Ecmel Mehmetbeyoglu, Leila Kianmehr, Murat Borlu, Zeynep Yilmaz, Seyma Basar Kılıc, Hassan Rajabi-Maham, Serpil Taheri, Minoo Rassoulzadegan

Biomolecules. 2022 Mar; 12(3): 368. Published online 2022 Feb 25. doi: 10.3390/biom12030368

PMCID:: PMC8945458

Abstract Article PDF–5.9M

Select item 866666510.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 827460311.

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

Jérémy A. Ferreira Barbosa, Samantha Sparapani, Jonathan Boulais, Robert Lodge, Éric A. Cohen

J Virol. 2021 Aug; 95(15): e00971-20. Prepublished online 2021 May 19. Published online 2021 Jul 12. doi: 10.1128/JVI.00971-20

PMCID:: PMC8274603

Abstract Article PDF–4.2M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 787370113.

Global proteomics of Ubqln2-based murine models of ALS

Alexandra M. Whiteley, Miguel A. Prado, Stefanie A.H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley

J Biol Chem. 2021 Jan-Jun; 296: 100153. Published online 2020 Dec 10. doi: 10.1074/jbc.RA120.015960

PMCID:: PMC7873701

Abstract Article PDF–3.0M

Select item 775692014.

Germline variation of Ribonuclease H2 genes in ovarian cancer patients

Rahel Polaczek, Peter Schürmann, Lisa-Marie Speith, Robert Geffers, Matthias Dürst, Peter Hillemanns, Tjoung-Won Park-Simon, Clemens Liebrich, Thilo Dörk

J Ovarian Res. 2020; 13: 146. Published online 2020 Dec 22. doi: 10.1186/s13048-020-00753-1

PMCID:: PMC7756920

Abstract Article PDF–758K

Select item 742732715.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 730149916.

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding, Chengbiao Wu

Transl Neurodegener. 2020; 9: 26. Published online 2020 Jun 18. doi: 10.1186/s40035-020-00206-1

PMCID:: PMC7301499

Abstract Article PDF–14M

Select item 694204417.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 645076918.

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Chao Wang, Gang Wang, Xu Feng, Peter Shepherd, Jie Zhang, Mengfan Tang, Zhen Chen, Mrinal Srivastava, Megan E. McLaughlin, Nora M. Navone, Glen Traver Hart, Junjie Chen

Oncogene. Author manuscript; available in PMC 2019 Jun 7.

Published in final edited form as: Oncogene. 2019 Apr; 38(14): 2451–2463. Published online 2018 Dec 7. doi: 10.1038/s41388-018-0606-4

PMCID:: PMC6450769

Abstract Article PDF–1.9M

Select item 642409819.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz

iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026

PMCID:: PMC6424098

Abstract Article PDF–11M

Select item 635598120.

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1

Junfen Xu, Habin Liu, Yanqin Yang, Xiaohong Wang, Poching Liu, Yang Li, Craig Meyers, Nilam Sanjib Banerjee, Hsu-Kun Wang, Maggie Cam, Weiguo Lu, Louise T. Chow, Xing Xie, Jun Zhu, Zhi-Ming Zheng

mBio. 2019 Jan-Feb; 10(1): e02687-18. Published online 2019 Jan 29. doi: 10.1128/mBio.02687-18

PMCID:: PMC6355981

Abstract Article PDF–5.1M

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