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Select item 111585071.

Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma

Sang G. Jung, Young D. Kwon, Ji A. Song, Min J. Back, Sun Y. Lee, Chan Lee, Yoon Y. Hwang, Hee J. An

Cancer Sci. 2010 Sep; 101(9): 1977–1983. Published online 2010 Jun 9. doi: 10.1111/j.1349-7006.2010.01641.x

PMCID:: PMC11158507

Abstract Article PDF–540K

Select item 110636902.

Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma

Handan Xiang, Yidan Pan, Marc A. Sze, Marta Wlodarska, Ling Li, Karyn Ann van de Mark, Haleema Qamar, Casey J. Moure, Douglas E. Linn, Josephine Hai, Ying Huo, James Clarke, Tze Guan Tan, Samantha Ho, Karen W. Teng, Muhammad N. Ramli, Michael Nebozhyn, Chunsheng Zhang, Julianne Barlow, Corinne E. Gustafson, Savanna Gornisiewicz, Thomas P. Albertson, Stephanie L. Korle, Raphael Bueno, Lily Y. Moy, Elisabeth H. Vollmann, Derek Y. Chiang, Philip E. Brandish, Andrey Loboda

Cancer Res. 2024 May 2; 84(9): 1410–1425. Published online 2024 Feb 9. doi: 10.1158/0008-5472.CAN-23-1183

PMCID:: PMC11063690

Abstract Article PDF–15M

Select item 110227193.

Myofibrillogenesis Regulator‐1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin‐Protein Ligase Itchy Homolog in the Metastasis of Non‐Small Cell Lung Cancer

Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao

Adv Sci (Weinh) 2024 Apr; 11(15): 2306472. Published online 2024 Feb 11. doi: 10.1002/advs.202306472

PMCID:: PMC11022719

Abstract Article PDF–6.1M

Select item 110101044.

Association of Rare NOTCH3 Variants With Prevalent and Incident Stroke and Dementia in the General Population

Pei Wang, Ming Yao, Jing Yuan, Fei Han, Fei‐Fei Zhai, Ding‐Ding Zhang, Li‐Xin Zhou, Jun Ni, Shu‐Yang Zhang, Li‐Ying Cui, Yi‐Cheng Zhu

J Am Heart Assoc. 2024 Feb 20; 13(4): e032668. Published online 2024 Feb 13. doi: 10.1161/JAHA.123.032668

PMCID:: PMC11010104

Abstract Article PDF–769K

Select item 109064505.

DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells

Sanni Alve, Silvia Gramolelli, Joonas Jukonen, Susanna Juteau, Anne Pink, Atte A. Manninen, Satu Hänninen, Elisa Monto, Madeleine H. Lackman, Olli Carpén, Pipsa Saharinen, Sinem Karaman, Kari Vaahtomeri, Päivi M. Ojala

JCI Insight. 2024 Jan 9; 9(1): e171821. Published online 2024 Jan 9. doi: 10.1172/jci.insight.171821

PMCID:: PMC10906450

Abstract Article PDF–9.8M

Select item 108634246.

NOTCH3 C201R variant causes cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) that can be confused with early-onset Alzheimer’s disease

Olena Korvatska, Stephanie A. Bucks, Rebecca A. Yoda, Amber Nolan, Michael O. Dorschner, Debby Tsuang, Suman Jayadev, Wendy H. Raskind, Thomas D. Bird

J Neurol Sci. Author manuscript; available in PMC 2024 Feb 13.

Published in final edited form as: J Neurol Sci. 2023 Sep 15; 452: 120763. Published online 2023 Aug 7. doi: 10.1016/j.jns.2023.120763

PMCID:: PMC10863424

Abstract Article PDF–846K

Select item 108596097.

NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway

Xianchao Sun, Ying Zhang, Shiyong Xin, Liang Jin, Qiong Cao, Hong Wang, Keyi Wang, Xiang Liu, Chaozhi Tang, Weiyi Li, Ziyao Li, Xiaofei Wen, Guosheng Yang, Changcheng Guo, Zhiyu Liu, Lin Ye

Cancer Sci. 2024 Feb; 115(2): 412–426. Published online 2023 Dec 20. doi: 10.1111/cas.16040

PMCID:: PMC10859609

Abstract Article PDF–42M

Select item 108516138.

LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma

Xiaofeng Zhou, Zhizun Li, Moyu Li

BMC Womens Health. 2024; 24: 104. Published online 2024 Feb 8. doi: 10.1186/s12905-024-02905-7

PMCID:: PMC10851613

Abstract Article PDF–2.0M

Select item 108132659.

Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease

Ikuko Mizuta, Yumiko Nakao-Azuma, Hideki Yoshida, Masamitsu Yamaguchi, Toshiki Mizuno

Biomolecules. 2024 Jan; 14(1): 127. Published online 2024 Jan 18. doi: 10.3390/biom14010127

PMCID:: PMC10813265

Abstract Article PDF–4.4M

Select item 1073415710.

Notch3 restricts metastasis of breast cancers through regulation of the JAK/STAT5A signaling pathway

Min-Na Chen, Ze-Xuan Fang, Zheng Wu, Jing-Wen Bai, Rong-Hui Li, Xiao-Fen Wen, Guo-Jun Zhang, Jing Liu

BMC Cancer. 2023; 23: 1257. Published online 2023 Dec 20. doi: 10.1186/s12885-023-11746-w

PMCID:: PMC10734157

Abstract Article PDF–5.3M

Select item 1067371311.

The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma

Boyu Chen, Runda Huang, Tianliang Xia, Chunyang Wang, Xiao Xiao, Shunzhen Lu, Xiangfu Chen, Ying Ouyang, Xiaowu Deng, Jingjing Miao, Chong Zhao, Lin Wang

Oncogene. 2023; 42(48): 3564–3574. Published online 2023 Oct 18. doi: 10.1038/s41388-023-02865-6

PMCID:: PMC10673713

Abstract Article PDF–5.5M

Select item 1035580612.

Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways

Hannah E. Morris, Karla B. Neves, Margaret Nilsen, Augusto C. Montezano, Margaret R. MacLean, Rhian M. Touyz

Hypertension. 2023 Aug; 80(8): 1683–1696. Published online 2023 May 31. doi: 10.1161/HYPERTENSIONAHA.122.20449

PMCID:: PMC10355806

Abstract Article PDF–2.5M

Select item 1035166013.

Genetic spectrum and clinical features of adult leukoencephalopathies in a Chinese cohort

Minglei Liu, Yangyang Wang, Changhe Shi, Yanpeng Yuan, Lanjun Li, Xiaoyun Zhang, Yuming Xu, Jing Yang

Ann Clin Transl Neurol. 2023 Jul; 10(7): 1119–1135. Published online 2023 May 26. doi: 10.1002/acn3.51794

PMCID:: PMC10351660

Abstract Article PDF–5.3M

Select item 1031851614.

Structural changes in NOTCH3 induced by CADASIL mutations: Role of cysteine and non-cysteine alterations

Soo Jung Lee, Xiaojie Zhang, Emily Wu, Richard Sukpraphrute, Catherine Sukpraphrute, Andrew Ye, Michael M. Wang

J Biol Chem. 2023 Jun; 299(6): 104838. Published online 2023 May 19. doi: 10.1016/j.jbc.2023.104838

PMCID:: PMC10318516

Abstract Article PDF–1.1M

Select item 1019580615.

Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J. Pugh, Carl Virtanen, Jason Moffat, Reidar A. Grénman, Marianne Koritzinsky, Bradly G. Wouters

Commun Biol. 2023; 6: 538. Published online 2023 May 18. doi: 10.1038/s42003-023-04828-9

PMCID:: PMC10195806

Abstract Article PDF–2.9M

Select item 997523116.

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer

Sonia Brahim, Ana-Maria Negulescu, Clara Geneste, Thomas Schott, Shuheng Lin, Louis-Oscar Morel, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Patrick Mehlen, Olivier Meurette

Cell Death Dis. 2023 Feb; 14(2): 171. Published online 2023 Feb 28. doi: 10.1038/s41419-023-05674-7

PMCID:: PMC9975231

Abstract Article PDF–3.0M

Select item 990302717.

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao

Technol Cancer Res Treat. 2023; 22: 15330338221118984. Published online 2023 Feb 6. doi: 10.1177/15330338221118984

PMCID:: PMC9903027

Abstract Article PDF–1.6M

Select item 987535218.

Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors

Charlotte Dupé, Stéphanie Guey, Lucie Biard, Sokhna Dieng, Jessica Lebenberg, Lina Grosset, Nassira Alili, Dominique Hervé, Elisabeth Tournier-Lasserve, Eric Jouvent, Sylvie Chevret, Hugues Chabriat

J Cereb Blood Flow Metab. 2023 Jan; 43(1): 153–166. Published online 2022 Oct 17. doi: 10.1177/0271678X221126280