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Select item 110963751.

Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool

Haidi Huang, Yu Jiang, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang, Yongchun Zhang

Nat Commun. 2024; 15: 4124. Published online 2024 May 15. doi: 10.1038/s41467-024-48347-5

PMCID:: PMC11096375

Abstract Article PDF–9.5M

Select item 107999422.

Novel JAG1 variants leading to Alagille syndrome in two Chinese cases

Xiufang Feng, Jiangyuan Ping, Shan Gao, Dong Han, Wenxia Song, Xiaoze Li, Yilun Tao, Lihong Wang

Sci Rep. 2024; 14: 1812. Published online 2024 Jan 20. doi: 10.1038/s41598-024-52357-0

PMCID:: PMC10799942

Abstract Article PDF–1.3M

Select item 107253713.

Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway

Weizhao Li, Xunzhi Zhang, Tianshun Gao, Lixiang Liu, Chi Zhang, Huan Yang, Jiayuan Xie, Wei Pan, David Y. B. Deng, Changlin Zhang, Tian Li

J Cancer Res Clin Oncol. 2023; 149(20): 18093–18102. Published online 2023 Nov 23. doi: 10.1007/s00432-023-05495-3

PMCID:: PMC10725371

Abstract Article PDF–2.4M

Select item 107193444.

Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion

Jung Yun Kim, Nayoung Hong, Sehyeon Park, Seok Won Ham, Eun-Jung Kim, Sung-Ok Kim, Junseok Jang, Yoonji Kim, Jun-Kyum Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim

Cell Death Dis. 2023 Dec; 14(12): 822. Published online 2023 Dec 13. doi: 10.1038/s41419-023-06356-0

PMCID:: PMC10719344

Abstract Article PDF–12M

Select item 105774525.

Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate: Neuritin regulates the activity of the E3 ligase NEURL1

Jingling Zhu, Yu Li, Chen Zhong, Meiyi Zhu, Yan Zheng, Anying Xiong, Pingping Meng, Liya Shan, Yang Li, Jin Huang

Acta Biochim Biophys Sin (Shanghai) 2023 Oct 25; 55(10): 1650–1658. Published online 2023 May 29. doi: 10.3724/abbs.2023098

PMCID:: PMC10577452

Abstract Article PDF–1.8M

Select item 105734216.

Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells

Seok Won Ham, Jung Yun Kim, Sunyoung Seo, Nayoung Hong, Min Ji Park, Yoonji Kim, Junseok Jang, Sehyeon Park, Silvee Jisoo Lee, Jun-Kyum Kim, Eun-Jung Kim, Sung-Ok Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim

Int J Mol Sci. 2023 Oct; 24(19): 14776. Published online 2023 Sep 30. doi: 10.3390/ijms241914776

PMCID:: PMC10573421

Abstract Article PDF–3.9M

Select item 105630977.

JAG1影响单核-巨噬细胞重塑三阴性乳腺癌转移前微环境：基于外泌体中的LncRNA MALAT1

徐梦歧, 石宇彤, 刘俊平, 吴敏敏, 张凤梅, 何志强, 唐敏

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Sep 20; 43(9): 1525–1535. Chinese. doi: 10.12122/j.issn.1673-4254.2023.09.10

PMCID:: PMC10563097

Abstract Article PDF–2.2M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101939779.

Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells

Lijian Shao, Na Yoon Paik, Mark A. Sanborn, Thilinie Bandara, Anjali Vijaykumar, Kilian Sottoriva, Jalees Rehman, Cesar Nombela-Arrieta, Kostandin V. Pajcini

Proc Natl Acad Sci U S A. 2023 May 16; 120(20): e2210058120. Published online 2023 May 8. doi: 10.1073/pnas.2210058120

PMCID:: PMC10193977

Abstract Article PDF–5.4M

Select item 1008424610.

Isolated aneurysmal disease as an underestimated finding in individuals with JAG1 pathogenic variants

Jotte Rodrigues Bento, Alice Krebsová, Ilse Van Gucht, Irene Valdivia Callejon, An Van Berendoncks, Pavel Votypka, Ilse Luyckx, Petra Peldova, Steven Laga, Marek Havelka, Lut Van Laer, Pavel Trunecka, Nele Boeckx, Aline Verstraeten, Milan Macek, Josephina A. N. Meester, Bart Loeys

Hum Mutat. 2022 Dec; 43(12): 1824–1828. Published online 2022 Jul 16. doi: 10.1002/humu.24433

PMCID:: PMC10084246

Abstract Article PDF–1.1M

Select item 976812011.

JAG1 is associated with the prognosis and metastasis in breast cancer

Xiaojuan Qiao, Buhuan Ma, Weiting Sun, Ning Zhang, Yang Liu, Lizhou Jia, Caixia Liu

Sci Rep. 2022; 12: 21986. Published online 2022 Dec 20. doi: 10.1038/s41598-022-26241-8

PMCID:: PMC9768120

Abstract Article PDF–4.6M

Select item 969494112.

Indirect Immobilised Jagged-1 Enhances Matrisome Proteins Associated with Osteogenic Differentiation of Human Dental Pulp Stem Cells: A Proteomic Study

Ajjima Chansaenroj, Chatvadee Kornsuthisopon, Sittiruk Roytrakul, Suphalak Phothichailert, Sunisa Rochanavibhata, Benjamin P. J. Fournier, Supreda Suphanantachat Srithanyarat, Nunthawan Nowwarote, Thanaphum Osathanon

Int J Mol Sci. 2022 Nov; 23(22): 13897. Published online 2022 Nov 11. doi: 10.3390/ijms232213897

PMCID:: PMC9694941

Abstract Article PDF–9.7M

Select item 943284113.

JAG1-NOTCH4 mechanosensing drives atherosclerosis

Celine Souilhol, Blanca Tardajos Ayllon, Xiuying Li, Mannekomba R. Diagbouga, Ziqi Zhou, Lindsay Canham, Hannah Roddie, Daniela Pirri, Emily V. Chambers, Mark J. Dunning, Mark Ariaans, Jin Li, Yun Fang, Helle F. Jørgensen, Michael Simons, Rob Krams, Johannes Waltenberger, Maria Fragiadaki, Victoria Ridger, Sarah De Val, Sheila E. Francis, Timothy JA Chico, Jovana Serbanovic-Canic, Paul C. Evans

Sci Adv. 2022 Sep; 8(35): eabo7958. Published online 2022 Aug 31. doi: 10.1126/sciadv.abo7958

PMCID:: PMC9432841

Abstract Article PDF–2.6M

Select item 930886314.

JAG1影响血管生成并促进三阴性乳腺癌细胞的迁移、侵袭和粘附

刘俊平, 石宇彤, 吴敏敏, 徐梦岐, 张凤梅, 何志强, 唐敏

Nan Fang Yi Ke Da Xue Xue Bao. 2022 Jul 20; 42(7): 1100-1108, 封3. Chinese. doi: 10.12122/j.issn.1673-4254.2022.07.21

PMCID:: PMC9308863

Abstract Article PDF–3.8M

Select item 920351215.

Leptin modulated microRNA-628-5p targets Jagged-1 and inhibits prostate cancer hallmarks

Leslimar Rios-Colon, Juliet Chijioke, Suryakant Niture, Zainab Afzal, Qi Qi, Anvesha Srivastava, Malathi Ramalinga, Habib Kedir, Patrice Cagle, Elena Arthur, Mitu Sharma, John Moore, Gagan Deep, Simeng Suy, Sean P. Collins, Deepak Kumar

Sci Rep. 2022; 12: 10073. Published online 2022 Jun 16. doi: 10.1038/s41598-022-13279-x

PMCID:: PMC9203512

Abstract Article PDF–3.8M

Select item 910523516.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 910274417.

Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells

Teppei Nishino, Masaharu Yoshihara, Takahiro Nakayama, Takaho Tsuchiya, Saeko Tahara, Haruka Ozaki, Satoru Takahashi

BMC Res Notes. 2022; 15: 172. Published online 2022 May 13. doi: 10.1186/s13104-022-06058-4

PMCID:: PMC9102744

Abstract Article PDF–1.1M

Select item 839192918.

Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway

Kathleen Zohorsky, Shigang Lin, Kibret Mequanint

Cells. 2021 Aug; 10(8): 2089. Published online 2021 Aug 14. doi: 10.3390/cells10082089

PMCID:: PMC8391929

Abstract Article PDF–3.1M

Select item 825401119.

Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome

Mariana Matioli da Palma, Austin D. Igelman, Cristy Ku, Amanda Burr, Jia Yue You, Emily M. Place, Nan-Kai Wang, Jin Kyun Oh, Kari E. Branham, Xinxin Zhang, Jeeyun Ahn, Michael B. Gorin, Byron L. Lam, Cecinio C. Ronquillo, Paul S. Bernstein, Aaron Nagiel, Rachel Huckfeldt, Michelle T. Cabrera, John P. Kelly, Benjamin Bakall, Alessandro Iannaccone, Robert B. Hufnagel, Wadih M. Zein, Robert K. Koenekoop, David G. Birch, Paul Yang, Abigail T. Fahim, Mark E. Pennesi

Invest Ophthalmol Vis Sci. 2021 Jun; 62(7): 27. Published online 2021 Jun 29. doi: 10.1167/iovs.62.7.27