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Items: 1 to 20 of 36

1.
A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis
Lisha Chang, Jie Ding, Juan Pu, Jing Zhu, Xiang Zhou, Qian Luo, Jie Li, Mengsen Qian, Shuhui Lin, Juan Li, Keming Wang
J Exp Clin Cancer Res. 2024; 43: 185. Published online 2024 Jul 4. doi: 10.1186/s13046-024-03095-8
PMCID:
PMC11223299
AbstractArticlePDF–14M
2.
Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu
Respir Res. 2024; 25: 176. Published online 2024 Apr 24. doi: 10.1186/s12931-024-02816-z
PMCID:
PMC11040761
AbstractArticlePDF–15M
3.
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth
Huajie Mao, Runzhi Wang, Fengling Shao, Ming Zhao, Dayu Tian, Hua Xia, Ya Zhao
Sci Rep. 2023; 13: 14629. Published online 2023 Sep 5. doi: 10.1038/s41598-023-41343-7
PMCID:
PMC10480187
AbstractArticlePDF–12M
4.
HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study
Rongrong Ding, Tianyou Chen, Yuan Zhang, Xiaorong Chen, Liping Zhuang, Zongguo Yang
Sci Prog. 2021 Jul-Sep; 104(3): 00368504211031749. Published online 2021 Jul 14. doi: 10.1177/00368504211031749
PMCID:
PMC10358623
AbstractArticlePDF–2.9M
5.
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease
Mi Bai, Mengqiu Wu, Mingzhu Jiang, Jia He, Xu Deng, Shuang Xu, Jiaojiao Fan, Mengqiu Miao, Ting Wang, Yuting Li, Xiaowen Yu, Lin Wang, Yue Zhang, Songming Huang, Li Yang, Zhanjun Jia, Aihua Zhang
EMBO Mol Med. 2023 Feb; 15(2): e16581. Published online 2023 Jan 11. doi: 10.15252/emmm.202216581
PMCID:
PMC9906428
AbstractArticlePDF–14M
6.
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
Shaza Asif, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, Alix Denoncourt, Angela C. Cheung, Michael Downey, Erin E. Mulvihill, Kyoung-Han Kim
Mol Metab. 2022 Jul; 61: 101494. Published online 2022 Apr 12. doi: 10.1016/j.molmet.2022.101494
PMCID:
PMC9039870
AbstractArticlePDF–5.9M
7.
PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
Cells. 2021 Dec; 10(12): 3550. Published online 2021 Dec 16. doi: 10.3390/cells10123550
PMCID:
PMC8700377
AbstractArticlePDF–2.5M
8.
SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis
Jie Li, Ming-han Li, Tian-tian Wang, Xiao-ning Liu, Xiao-ting Zhu, Yun-zhang Dai, Ke-chao Zhai, Yong-da Liu, Jia-li Lin, Rui-liang Ge, Shu-han Sun, Fang Wang, Ji-hang Yuan
Br J Cancer. 2021 Sep 14; 125(6): 865–876. Published online 2021 Jul 17. doi: 10.1038/s41416-021-01490-y
PMCID:
PMC8438090
AbstractArticlePDF–2.3M
9.
Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation
Lei Fang, Tu-Shuai Li, Jing-Zi Zhang, Zhi-Hong Liu, Jie Yang, Bing-Hao Wang, Yu-Meng Wang, Jie Zhou, Ling-Dong Kong
Signal Transduct Target Ther. 2021; 6: 253. Published online 2021 Jul 9. doi: 10.1038/s41392-021-00570-y
PMCID:
PMC8266798
ArticlePDF–1.5M
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex
Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle
Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834
PMCID:
PMC7226812
AbstractArticlePDF–2.3M
12.
Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan
Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam
Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525
PMCID:
PMC7115128
AbstractArticlePDF–1.6M
13.
The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm
PLoS One. 2020; 15(1): e0227411. Published online 2020 Jan 7. doi: 10.1371/journal.pone.0227411
PMCID:
PMC6946174
AbstractArticlePDF–4.9M
14.
Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells
Ji Tae Kim, Chang Li, Heidi L. Weiss, Yuning Zhou, Chunming Liu, Qingding Wang, B. Mark Evers
Cells. 2019 Sep; 8(9): 1106. Published online 2019 Sep 19. doi: 10.3390/cells8091106
PMCID:
PMC6770209
AbstractArticlePDF–2.3M
15.
Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker
Kejian Zou, Yan Hu, Musheng Li, Hongli Wang, Yuhua Zhang, Ling Huang, Yuanwen Xie, Songyu Li, Xingui Dai, Wanfu Xu, Zhiyong Ke, Sitang Gong, Yaodong Wang
Can J Gastroenterol Hepatol. 2019; 2019: 8348967. Published online 2019 Jul 1. doi: 10.1155/2019/8348967
PMCID:
PMC6634068
AbstractArticlePDF–1.6M
16.
Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes
Chih-Yuan Fang, Mien-Cheng Chen, Tzu-Hao Chang, Chia-Chen Wu, Jen-Ping Chang, Hsien-Da Huang, Wan-Chun Ho, Yi-Zhen Wang, Kuo-Li Pan, Yu-Sheng Lin, Yao-Kuang Huang, Chien-Jen Chen, Wei-Chieh Lee
Int J Mol Sci. 2018 Dec; 19(12): 4094. Published online 2018 Dec 18. doi: 10.3390/ijms19124094
PMCID:
PMC6321625
AbstractArticlePDF–2.9M
17.
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies
Christina Schiza, Dimitrios Korbakis, Efstratia Panteleli, Keith Jarvi, Andrei P. Drabovich, Eleftherios P. Diamandis
Mol Cell Proteomics. 2018 Dec; 17(12): 2480–2495. Published online 2018 Aug 10. doi: 10.1074/mcp.RA118.000749
PMCID:
PMC6283293
AbstractArticlePDF–1.9M
18.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
19.
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients
Sonal Singh, Caitrin W. McDonough, Yan Gong, Wael A. Alghamdi, Meghan J. Arwood, Salma A. Bargal, Leanne Dumeny, Wen‐Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A. de Oliveira, Natalie C. Fredette, Mohamed H. Shahin, Kent R. Bailey, Amber L. Beitelshees, Eric Boerwinkle, Arlene B. Chapman, John G. Gums, Stephen T. Turner, Rhonda M. Cooper‐DeHoff, Julie A. Johnson
J Am Heart Assoc. 2018 Mar 20; 7(6): e007339. Published online 2018 Mar 9. doi: 10.1161/JAHA.117.007339
PMCID:
PMC5907544
AbstractArticlePDF–987K
20.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M

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