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Items: 1 to 20 of 81

1.
Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson
Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8
PMCID:
PMC10499821
AbstractArticlePDF–2.6M
2.
NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1
Bin Zhang, Shaowei Dong, Jian Wang, Tuxiong Huang, Pan Zhao, Jing Xu, Dongcheng Liu, Li Fu, Lingwei Wang, Guangsuo Wang, Chang Zou
Nat Commun. 2023; 14: 3183. Published online 2023 Jun 2. doi: 10.1038/s41467-023-38833-7
PMCID:
PMC10238419
AbstractArticlePDF–5.5M
3.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
4.
Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis
Weijun Fang, Hua Liu, Lianhua Qin, Jie Wang, Xiaochen Huang, Sha Pan, Ruijuan Zheng
Front Immunol. 2023; 14: 1081483. Published online 2023 Feb 2. doi: 10.3389/fimmu.2023.1081483
PMCID:
PMC9933242
AbstractArticlePDF–4.2M
5.
Downregulation of Notch4 – a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma
M.K. Harishankar, A. Mathan Mohan, A. Vinod Krishnan, Arikketh Devi
Braz J Otorhinolaryngol. 2019 Jan-Feb; 85(1): 11–16. Published online 2017 Oct 31. doi: 10.1016/j.bjorl.2017.09.005
PMCID:
PMC9442864
AbstractArticlePDF–946K
6.
JAG1-NOTCH4 mechanosensing drives atherosclerosis
Celine Souilhol, Blanca Tardajos Ayllon, Xiuying Li, Mannekomba R. Diagbouga, Ziqi Zhou, Lindsay Canham, Hannah Roddie, Daniela Pirri, Emily V. Chambers, Mark J. Dunning, Mark Ariaans, Jin Li, Yun Fang, Helle F. Jørgensen, Michael Simons, Rob Krams, Johannes Waltenberger, Maria Fragiadaki, Victoria Ridger, Sarah De Val, Sheila E. Francis, Timothy JA Chico, Jovana Serbanovic-Canic, Paul C. Evans
Sci Adv. 2022 Sep; 8(35): eabo7958. Published online 2022 Aug 31. doi: 10.1126/sciadv.abo7958
PMCID:
PMC9432841
AbstractArticlePDF–2.6M
7.
NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma
Hongxia Li, Qin Zhang, Qianqian Duan, Yuan Tan, Tingting Sun, Chuang Qi
Front Immunol. 2022; 13: 894110. Published online 2022 Jul 29. doi: 10.3389/fimmu.2022.894110
PMCID:
PMC9372281
AbstractArticlePDF–1.4M
8.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
9.
NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling
Susana López-López, María José Romero de Ávila, Natalia Carolina Hernández de León, Francisco Ruiz-Marcos, Victoriano Baladrón, María Luisa Nueda, Jorge Laborda, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra
Front Immunol. 2021; 12: 734966. Published online 2021 Dec 1. doi: 10.3389/fimmu.2021.734966
PMCID:
PMC8671160
AbstractArticlePDF–3.9M
10.
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Sarah Grosche, Ingo Marenholz, Jorge Esparza-Gordillo, Aleix Arnau-Soler, Erola Pairo-Castineira, Franz Rüschendorf, Tarunveer S. Ahluwalia, Catarina Almqvist, Andreas Arnold, Australian Asthma Genetics Consortium (AAGC), Hansjörg Baurecht, Hans Bisgaard, Klaus Bønnelykke, Sara J. Brown, Mariona Bustamante, John A. Curtin, Adnan Custovic, Shyamali C. Dharmage, Ana Esplugues, Mario Falchi, Dietmar Fernandez-Orth, Manuel A. R. Ferreira, Andre Franke, Sascha Gerdes, Christian Gieger, Hakon Hakonarson, Patrick G. Holt, Georg Homuth, Norbert Hubner, Pirro G. Hysi, Marjo-Riitta Jarvelin, Robert Karlsson, Gerard H. Koppelman, Susanne Lau, Manuel Lutz, Patrik K. E. Magnusson, Guy B. Marks, Martina Müller-Nurasyid, Markus M. Nöthen, Lavinia Paternoster, Craig E. Pennell, Annette Peters, Konrad Rawlik, Colin F. Robertson, Elke Rodriguez, Sylvain Sebert, Angela Simpson, Patrick M. A. Sleiman, Marie Standl, Dora Stölzl, Konstantin Strauch, Agnieszka Szwajda, Albert Tenesa, Philip J. Thompson, Vilhelmina Ullemar, Alessia Visconti, Judith M. Vonk, Carol A. Wang, Stephan Weidinger, Matthias Wielscher, Catherine L. Worth, Chen-Jian Xu, Young-Ae Lee
Nat Commun. 2021; 12: 6618. Published online 2021 Nov 16. doi: 10.1038/s41467-021-26783-x
PMCID:
PMC8595373
AbstractArticlePDF–1.6M
11.
Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy
Junyu Long, Dongxu Wang, Xu Yang, Anqiang Wang, Yu Lin, Mingjun Zheng, Haohai Zhang, Xinting Sang, Hanping Wang, Ke Hu, Haitao Zhao
BMC Med. 2021; 19: 154. Published online 2021 Jul 21. doi: 10.1186/s12916-021-02031-3
PMCID:
PMC8293505
AbstractArticlePDF–2.3M
12.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections
Hani Harb, Mehdi Benamar, Peggy S. Lai, Paola Contini, Jason W. Griffith, Elena Crestani, Klaus Schmitz-Abe, Qian Chen, Jason Fong, Luca Marri, Gilberto Filaci, Genny Del Zotto, Novalia Pishesha, Stephen Kolifrath, Achille Broggi, Sreya Ghosh, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Ayca Kiykim, Murat Kose, Ziwei Wang, Ye Cui, Xu G. Yu, Jonathan Z. Li, Lorenzo Berra, Emmanuel Stephen-Victor, Louis-Marie Charbonnier, Ivan Zanoni, Hidde Ploegh, Gunnur Deniz, Raffaele De Palma, Talal A. Chatila
Immunity. 2021 Jun 8; 54(6): 1186–1199.e7. Published online 2021 Apr 28. doi: 10.1016/j.immuni.2021.04.002
PMCID:
PMC8080416
AbstractArticlePDF–5.5M
13.
Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma
Takahito Fukusumi, Theresa W. Guo, Shuling Ren, Sunny Haft, Chao Liu, Akihiro Sakai, Mizuo Ando, Yuki Saito, Sayed Sadat, Joseph A. Califano
Int J Oncol. 2021 Feb; 58(2): 226–237. Published online 2020 Dec 10. doi: 10.3892/ijo.2020.5156
PMCID:
PMC7864008
AbstractArticlePDF–1.3M
14.
NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis
Ke Jin, Zhenke Wen, Bowen Wu, Hui Zhang, Jingtao Qiu, Yanan Wang, Kenneth J. Warrington, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
J Clin Invest. 2021 Jan 4; 131(1): e136042. Published online 2021 Jan 4. doi: 10.1172/JCI136042
PMCID:
PMC7773364
AbstractArticlePDF–2.6M
15.
Methylation status of CpG sites in the NOTCH4 promoter region regulates NOTCH4 expression in patients with tetralogy of Fallot
Yanjie Zhu, Ming Ye, Hongfei Xu, Ruoyi Gu, Xiaojing Ma, Mingwu Chen, Xiaodi Li, Wei Sheng, Guoying Huang
Mol Med Rep. 2020 Nov; 22(5): 4412–4422. Published online 2020 Sep 24. doi: 10.3892/mmr.2020.11535
PMCID:
PMC7533461
AbstractArticlePDF–878K
16.
A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits
Xiaohui Xie, Meidan Zu, Long Zhang, Tongjian Bai, Ling Wei, Wanling Huang, Gong-Jun Ji, Bensheng Qiu, Panpan Hu, Yanghua Tian, Kai Wang
BMC Psychiatry. 2020; 20: 363. Published online 2020 Jul 9. doi: 10.1186/s12888-020-02773-z
PMCID:
PMC7346398
AbstractArticlePDF–1.3M
17.
Association of GWAS‐supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population
Si‐Qiao Liang, Jing‐Min Deng, Xuan Wei, Zhang‐Rong Chen, Mei‐Ling Yang, Hua‐jiao Qin, Jian‐quan Zhang, Zhi‐yi He
J Clin Lab Anal. 2020 Feb; 34(2): e23066. Published online 2019 Oct 12. doi: 10.1002/jcla.23066
PMCID:
PMC7031573
AbstractArticlePDF–315K
18.
The NOTCH4-HEY1 pathway induces epithelial mesenchymal transition in head and neck squamous cell carcinoma
Takahito Fukusumi, Theresa W Guo, Akihiro Sakai, Mizuo Ando, Shuling Ren, Sunny Haft, Chao Liu, Panomwat Amornphimoltham, J. Silvio Gutkind, Joseph A Califano
Clin Cancer Res. Author manuscript; available in PMC 2019 Feb 1.
Published in final edited form as: Clin Cancer Res. 2018 Feb 1; 24(3): 619–633. Published online 2017 Nov 16. doi: 10.1158/1078-0432.CCR-17-1366
PMCID:
PMC6171749
AbstractArticlePDF–1.3M
19.
Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
Yueying Li, Chen Jin, Hao Bai, Yongxing Gao, Shu Sun, Lei Chen, Lei Qin, Paul P. Liu, Linzhao Cheng, Qian-Fei Wang
Blood. 2018 Jan 11; 131(2): 191–201. Prepublished online 2017 Nov 3. doi: 10.1182/blood-2017-04-780379
PMCID:
PMC5757696
AbstractArticle
20.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Min Liu, Kaili Liang, Junhui Zhen, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Yu Sun, Zhuanli Zhou, Hua Su, Chun Zhang, Ningjun Li, Chengjiang Gao, Jun Peng, Fan Yi
Nat Commun. 2017; 8: 413. Published online 2017 Sep 4. doi: 10.1038/s41467-017-00498-4
PMCID:
PMC5583183
AbstractArticlePDF–13M

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