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Select item 111786081.

Unmasking early colorectal cancer clues: in silico and in vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in SSA polyps

Seyedeh Nasim Mirbahari, Nayeralsadat Fatemi, Sanaz Savabkar, Vahid Chaleshi, Neda Zali, Mohammad Yaghoob Taleghani, Ebrahim Mirzaei, Leili Rejali, Pardis Ketabi Moghadam, Ehsan Nazemalhosseini Mojarad

Mol Biol Rep. 2024; 51(1): 764. Published online 2024 Jun 14. doi: 10.1007/s11033-024-09683-3

PMCID:: PMC11178608

Abstract Article PDF–2.9M

Select item 111598622.

Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC‐associated familial predisposition to cancer

Y. Hirai, K. Banno, M. Suzuki, Y. Ichikawa, Y. Udagawa, K. Sugano, Y. Miki

Cancer Sci. 2008 Sep; 99(9): 1715–1719. Published online 2008 Jul 9. doi: 10.1111/j.1349-7006.2008.00886.x

PMCID:: PMC11159862

Abstract Article PDF–128K

Select item 111598403.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer

Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park

Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x

PMCID:: PMC11159840

Abstract Article PDF–209K

Select item 111593634.

Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: Clinical and prognostic significance

Amlan Ghosh, Susmita Ghosh, Guru Prasad Maiti, Mohammad Golam Sabbir, Eugene R. Zabarovsky, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

Cancer Sci. 2010 Jun; 101(6): 1511–1520. Published online 2010 Mar 4. doi: 10.1111/j.1349-7006.2010.01551.x

PMCID:: PMC11159363

Abstract Article PDF–891K

Select item 111582545.

Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late‐onset breast carcinoma: clinical and prognostic significance

Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda

Cancer Sci. 2008 Oct; 99(10): 1984–1991. Published online 2008 Oct 14. doi: 10.1111/j.1349-7006.2008.00952.x

PMCID:: PMC11158254

Abstract Article PDF–609K

Select item 111550296.

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra, Muralidhar L. Hegde

Mol Brain. 2024; 17: 32. Published online 2024 Jun 5. doi: 10.1186/s13041-024-01108-3

PMCID:: PMC11155029

Abstract Article PDF–1.7M

Select item 111096127.

Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention

Qu Yue, Zhao Wang, Yixiong Shen, Yufei Lan, Xiangyang Zhong, Xin Luo, Tao Yang, Manqing Zhang, Boming Zuo, Tianci Zeng, Jiankun Lu, Yuankai Wang, Boyang Liu, Hongbo Guo

Adv Sci (Weinh) 2024 May; 11(19): 2309290. Published online 2024 Mar 13. doi: 10.1002/advs.202309290

PMCID:: PMC11109612

Abstract Article PDF–15M

Select item 111085198.

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld

Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2

PMCID:: PMC11108519

Abstract Article PDF–1.2M

Select item 108242499.

Variable Expression of MSH6 in Endometrial Carcinomas with Intact Mismatch Repair and with MLH1 Loss due to MLH1 Methylation

Nidhi Tandon, Courtney Hudgens, Bryan Fellman, Michael T. Tetzlaff, Russell R. Broaddus

Int J Gynecol Pathol. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Int J Gynecol Pathol. 2020 Nov; 39(6): 507–513. doi: 10.1097/PGP.0000000000000655

PMCID:: PMC10824249

Abstract Article PDF–1.8M

Select item 1080927110.

Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Seyed Mohsen Mirabdolhosseini, Mohammad Yaghoob Taleghani, Leili Rejali, Hossein Sadeghi, Nayeralsadat Fatemi, Mehdi Tavallaei, Amin Famil Meyari, Narges Saeidi, Pardis Ketabi Moghadam, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad

Cancer Rep (Hoboken) 2024 Jan; 7(1): e1930. Published online 2023 Nov 2. doi: 10.1002/cnr2.1930

PMCID:: PMC10809271

Abstract Article PDF–4.7M

Select item 1068521911.

MLH1 rs1800734 Pathogenic Variant among Patients with Colorectal Cancer in the Lower Northeastern Region of Thailand

Malinee Pongsavee, Kamol Wisuwan, Kritpipat Pongsavee

Asian Pac J Cancer Prev. 2023; 24(8): 2911–2916. doi: 10.31557/APJCP.2023.24.8.2911

PMCID:: PMC10685219

Abstract Article PDF–390K

Select item 1067094112.

MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

Ileana Wanda Carnevali, Giulia Cini, Laura Libera, Nora Sahnane, Sofia Facchi, Alessandra Viel, Fausto Sessa, Maria Grazia Tibiletti

Genes (Basel) 2023 Nov; 14(11): 2060. Published online 2023 Nov 9. doi: 10.3390/genes14112060

PMCID:: PMC10670941

Abstract Article PDF–1.5M

Select item 1051946913.

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study

Masanao Kaneko, Mitsuko Nakashima, Kiichi Sugiura, Natsuki Ishida, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Kyota Tatsuta, Kiyotaka Kurachi, Satoshi Baba, Yuji Iwashita, Tomio Arai, Haruhiko Sugimura, Masato Maekawa, Ken Sugimoto, Moriya Iwaizumi

Medicine (Baltimore) 2023 Sep 22; 102(38): e35022. Published online 2023 Sep 22. doi: 10.1097/MD.0000000000035022

PMCID:: PMC10519469

Abstract Article PDF–708K

Select item 1050888814.

Prevalence of Somatic MutL Homolog 1 Promoter Hypermethylation in Lynch Syndrome Colorectal Cancer

Leticia Moreira, Jenifer Muñoz, Míriam Cuatrecasas, Isabel Quintanilla, Maria Liz Leoz, Sabela Carballal, Teresa Ocaña, María López-Cerón, Maria Pellise, Sergi Castellví-Bel, Rodrigo Jover, Montserrat Andreu, Angel Carracedo, Rosa Maria Xicola, Xavier Llor, Clement Richard Boland, Ajay Goel, Antoni Castells, Francesc Balaguer, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association

Cancer. Author manuscript; available in PMC 2023 Sep 19.

Published in final edited form as: Cancer. 2015 May 1; 121(9): 1395–1404. Published online 2014 Dec 29. doi: 10.1002/cncr.29190

PMCID:: PMC10508888

Abstract Article PDF–418K

Select item 1039734415.

Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα

May-Britt Firnau, Guido Plotz, Stefan Zeuzem, Angela Brieger

Sci Rep. 2023; 13: 12503. Published online 2023 Aug 2. doi: 10.1038/s41598-023-39750-x

PMCID:: PMC10397344

Abstract Article PDF–1.7M

Select item 1032590016.

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Nucleic Acids Res. 2023 Jul 7; 51(12): 6307–6320. Published online 2023 May 24. doi: 10.1093/nar/gkad418

PMCID:: PMC10325900

Abstract Article PDF–1.7M

Select item 1030957017.

MLH1 Loss in Primary Prostate Cancer

Sanaz Nourmohammadi Abadchi, Laura A. Sena, Emmanuel S. Antonarakis, Colin C. Pritchard, James R. Eshleman, Eric Q. Konnick, Stephen J. Salipante, Eugene Shenderov, Tamara L. Lotan

JCO Precis Oncol. 2023; 7: e2200611. Published online 2023 May 17. doi: 10.1200/PO.22.00611

PMCID:: PMC10309570

Abstract Article PDF–899K

Select item 1028411718.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 1023742219.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1000589820.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

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