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Select item 97053141.

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak

Sci Rep. 2022; 12: 20435. Published online 2022 Nov 28. doi: 10.1038/s41598-022-24716-2

PMCID:: PMC9705314

Abstract Article PDF–3.4M

Select item 87197312.

Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1

Ting-Yun Chen, Xiaoyun Li, Gillian C. Goobie, Ching-Hsia Hung, Tin-Kan Hung, Kyle Hamilton, Harinath Bahudhanapati, Jiangning Tan, Daniel J. Kass, Yingze Zhang

PLoS One. 2021; 16(12): e0254466. Published online 2021 Dec 31. doi: 10.1371/journal.pone.0254466

PMCID:: PMC8719731

Abstract Article PDF–3.0M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 69888564.

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis

Elena M. Kaftanovskaya, Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Courtney Myhr, Brian A. Ho, Briana A. Cervantes, Thomas D. Shupe, Mahesh Devarasetty, Xin Hu, Xin Xu, Samarjit Patnaik, Kenneth J. Wilson, Elena Barnaeva, Marc Ferrer, Noel T. Southall, Juan J. Marugan, Colin E. Bishop, Irina U. Agoulnik, Alexander I. Agoulnik

FASEB J. 2019 Nov; 33(11): 12435–12446. Published online 2019 Nov. doi: 10.1096/fj.201901046R

PMCID:: PMC6988856

Abstract Article

Select item 65524325.

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression

Jung-Sik Kim, Xiaoyuan He, Jie Liu, Zhijun Duan, Taeyeon Kim, Julia Gerard, Brian Kim, Manoj M. Pillai, William S. Lane, William S. Noble, Bogdan Budnik, Todd Waldman

J Biol Chem. 2019 May 31; 294(22): 8760–8772. Published online 2019 Apr 22. doi: 10.1074/jbc.RA119.007832

PMCID:: PMC6552432

Abstract Article PDF–3.5M

Select item 64420416.

MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis

Harinath Bahudhanapati, Jiangning Tan, Justin A. Dutta, Stephen B. Strock, John Sembrat, Diana Àlvarez, Mauricio Rojas, Benedikt Jäger, Antje Prasse, Yingze Zhang, Daniel J. Kass

J Biol Chem. 2019 Mar 29; 294(13): 5008–5022. Published online 2019 Feb 1. doi: 10.1074/jbc.RA118.004910

PMCID:: PMC6442041

Abstract Article PDF–2.7M

Select item 60777227.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 51481418.

Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies

Jiangning Tan, John R. Tedrow, Justin A. Dutta, Brenda Juan-Guardela, Mehdi Nouraie, Yanxia Chu, Humberto Trejo Bittar, Kritika Ramani, Partha S. Biswas, Kristen L. Veraldi, Naftali Kaminski, Yingze Zhang, Daniel J. Kass

Am J Respir Crit Care Med. 2016 Dec 1; 194(11): 1392–1402. Published online 2016 Dec 1. doi: 10.1164/rccm.201509-1865OC

PMCID:: PMC5148141

Abstract Article PDF–1.0M

Select item 51346809.

Hormone Receptor Expression in Human Fascial Tissue

C. Fede, G. Albertin, L. Petrelli, M.M. Sfriso, C. Biz, R. De Caro, C. Stecco

Eur J Histochem. 2016 Nov 2; 60(4): 2710. Published online 2016 Nov 2. doi: 10.4081/ejh.2016.2710

PMCID:: PMC5134680

Abstract Article PDF–463K

Select item 483748210.

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley

Nat Commun. 2016; 7: 11344. Published online 2016 Apr 18. doi: 10.1038/ncomms11344

PMCID:: PMC4837482

Abstract Article PDF–889K

Select item 480419611.

Identification of small molecule agonists of human relaxin family receptor 1 (RXFP1) by utilizing a homogenous cell-based cAMP assay

Catherine Z. Chen, Noel Southall, Jingbo Xiao, Juan J. Marugan, Marc Ferrer, Xin Hu, Raisa E. Jones, Shu Feng, Irina U. Agoulnik, Wei Zheng, Alexander I. Agoulnik

J Biomol Screen. Author manuscript; available in PMC 2016 Mar 23.

Published in final edited form as: J Biomol Screen. 2013 Jul; 18(6): 670–677. Published online 2012 Dec 4. doi: 10.1177/1087057112469406

PMCID:: PMC4804196

Abstract Article PDF–557K

Select item 431757712.

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B. Nair, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed Akhter Hossain, John D. Wade

Biomed Res Int. 2015; 2015: 731852. Published online 2015 Jan 22. doi: 10.1155/2015/731852

PMCID:: PMC4317577

Abstract Article PDF–1.0M

Select item 429452213.

Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)

Sudhir Singh, Ronda L. Simpson, Robert G. Bennett

J Biol Chem. 2015 Jan 9; 290(2): 950–959. Published online 2014 Nov 11. doi: 10.1074/jbc.M114.589325

PMCID:: PMC4294522

Abstract Article PDF–1.6M

Select item 385533014.

Expression of LGR7 in the Primate Corpus Luteum Implicates the Corpus Luteum as a Relaxin Target Organ

Priya B. Maseelall, Aimee Seungdamrong, Gerson Weiss, Andrea S. Wojtczuk, Robert Donnelly, Richard L. Stouffer, Laura T. Goldsmith.

Ann N Y Acad Sci. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Ann N Y Acad Sci. 2009 Apr; 1160: 10.1111/j.1749-6632.2009.03946.x. doi: 10.1111/j.1749-6632.2009.03946.x

PMCID:: PMC3855330

Abstract Article PDF–355K

Select item 378472515.

The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation

Roy C. K. Kong, Emma J. Petrie, Biswaranjan Mohanty, Jason Ling, Jeremy C. Y. Lee, Paul R. Gooley, Ross A. D. Bathgate

J Biol Chem. 2013 Sep 27; 288(39): 28138–28151. Published online 2013 Aug 7. doi: 10.1074/jbc.M113.499640

PMCID:: PMC3784725

Abstract Article PDF–1.8M

Select item 371364616.

Relaxin, Its Receptor (RXFP1), and Insulin-Like Peptide 4 Expression Through Gestation and in Placenta Accreta

William Goh, Sandra Y. Yamamoto, Karen S. Thompson, Gillian D. Bryant-Greenwood

Reprod Sci. 2013 Aug; 20(8): 968–980. doi: 10.1177/1933719112472735

PMCID:: PMC3713646

Abstract Article PDF–961K

Select item 351081517.

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J. Chan, K. Johan Rosengren, Sharon L. Layfield, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed A. Hossain, John D. Wade

J Biol Chem. 2012 Nov 30; 287(49): 41152–41164. Published online 2012 Sep 28. doi: 10.1074/jbc.M112.409284

PMCID:: PMC3510815

Abstract Article PDF–2.5M

Select item 348762218.

The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

Daniel J. Scott, K. Johan Rosengren, Ross A. D. Bathgate

Mol Endocrinol. 2012 Nov; 26(11): 1896–1906. Published online 2012 Sep 12. doi: 10.1210/me.2012-1188

PMCID:: PMC3487622

Abstract Article

Select item 338086819.

A Novel Role for Relaxin-2 in the Pathogenesis of Primary Varicosis

Julia Adams, Sarah Schott, Arno Bern, Matthias Renz, Kristian Ikenberg, Claus Garbe, Christian Busch

PLoS One. 2012; 7(6): e39021. Published online 2012 Jun 21. doi: 10.1371/journal.pone.0039021

PMCID:: PMC3380868

Abstract Article PDF–1.0M

Select item 335656020.

Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia

E Ellinghaus, M Stanulla, G Richter, D Ellinghaus, G te Kronnie, G Cario, G Cazzaniga, M Horstmann, R Panzer Grümayer, H Cavé, J Trka, O Cinek, A Teigler-Schlegel, A ElSharawy, R Häsler, A Nebel, B Meissner, T Bartram, F Lescai, C Franceschi, M Giordan, P Nürnberg, B Heinzow, M Zimmermann, S Schreiber, M Schrappe, A Franke

Leukemia. 2012 May; 26(5): 902–909. Published online 2011 Nov 11. doi: 10.1038/leu.2011.302

PMCID:: PMC3356560

Abstract Article PDF–456K

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