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Select item 112271181.

OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis-regulatory elements

Jenny L. Kerschner, Alekh Paranjapye, Monali NandyMazumdar, Shiyi Yin, Shih-Hsing Leir, Ann Harris

Dev Dyn. Author manuscript; available in PMC 2024 Jul 6.

Published in final edited form as: Dev Dyn. 2021 May; 250(5): 684–700. Published online 2021 Jan 26. doi: 10.1002/dvdy.293

PMCID:: PMC11227118

Abstract Article PDF–2.2M

Select item 110503162.

The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas

Elisabet Ampudia-Mesias, Charles S. Cameron, Eunjae Yoo, Marcus Kelly, Sarah M. Anderson, Riley Manning, Juan E. Abrahante Lloréns, Christopher L. Moertel, Hyungshin Yim, David J. Odde, Nurten Saydam, Okay Saydam

Int J Mol Sci. 2024 Apr; 25(8): 4416. Published online 2024 Apr 17. doi: 10.3390/ijms25084416

PMCID:: PMC11050316

Abstract Article PDF–2.6M

Select item 109332673.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 98519734.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 98448535.

The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration

Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold, Mai Eshel, Shai Ovadia, Nitay Zuk-Bar, Maria Idelson, Yamit Cohen-Tayar, Benjamin Reubinoff, Tamar Ziv, Meir Shamay, Ran Elkon, Ruth Ashery-Padan

PLoS Biol. 2023 Jan; 21(1): e3001924. Published online 2023 Jan 17. doi: 10.1371/journal.pbio.3001924

PMCID:: PMC9844853

Abstract Article PDF–2.8M

Select item 98074716.

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: “it’s a numbers game”—implications for WNT medulloblastoma dose-reduction clinical trials

Nicholas G. Gottardo

Acta Neuropathol. 2023; 145(1): 145–147. Published online 2022 Nov 20. doi: 10.1007/s00401-022-02518-0

PMCID:: PMC9807471

Article PDF–422K

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80090488.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 75668819.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 732257810.

Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease

Hironori Bando, Peter Gergics, Brenda L Bohnsack, Kevin P Toolan, Catherine E Richter, Jordan A Shavit, Sally A Camper

Hum Mol Genet. 2020 Jun 27; 29(10): 1648–1657. Published online 2020 Apr 9. doi: 10.1093/hmg/ddaa064

PMCID:: PMC7322578

Abstract Article PDF–946K

Select item 716998311.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 699415312.

Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells

Ryusaku Matsumoto, Hidetaka Suga, Takashi Aoi, Hironori Bando, Hidenori Fukuoka, Genzo Iguchi, Satoshi Narumi, Tomonobu Hasegawa, Keiko Muguruma, Wataru Ogawa, Yutaka Takahashi

J Clin Invest. 2020 Feb 3; 130(2): 641–654. Published online 2019 Dec 17. doi: 10.1172/JCI127378

PMCID:: PMC6994153

Abstract Article PDF–13M

Select item 613575313.

Methylation in OTX2 and related genes, maltreatment, and depression in children

Joan Kaufman, Nicholas F. Wymbs, Janitza L. Montalvo-Ortiz, Catherine Orr, Matthew D. Albaugh, Robert Althoff, Kerry O’Loughlin, Hannah Holbrook, Hugh Garavan, Catherine Kearney, Bao-Zhu Yang, Hongyu Zhao, Catherine Peña, Eric J. Nestler, Richard S. Lee, Stewart Mostofsky, Joel Gelernter, James Hudziak

Neuropsychopharmacology. 2018 Oct; 43(11): 2204–2211. Published online 2018 Jul 21. doi: 10.1038/s41386-018-0157-y

PMCID:: PMC6135753

Abstract Article PDF–1.5M

Select item 589103914.

Characterization of a novel OTX2‐driven stem cell program in Group 3 and Group 4 medulloblastoma

Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie

Mol Oncol. 2018 Apr; 12(4): 495–513. Published online 2018 Mar 1. doi: 10.1002/1878-0261.12177

PMCID:: PMC5891039

Abstract Article PDF–1.6M

Select item 586825615.

Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition

Zhenghui Su, Yanqi Zhang, Baojian Liao, Xiaofen Zhong, Xin Chen, Haitao Wang, Yiping Guo, Yongli Shan, Lihui Wang, Guangjin Pan

J Biol Chem. 2018 Mar 23; 293(12): 4445–4455. Published online 2018 Jan 31. doi: 10.1074/jbc.M117.815449

PMCID:: PMC5868256

Abstract Article PDF–3.6M

Select item 576298416.

Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation

Christo Kole, Laurence Klipfel, Ying Yang, Vanessa Ferracane, Frederic Blond, Sacha Reichman, Géraldine Millet-Puel, Emmanuelle Clérin, Najate Aït-Ali, Delphine Pagan, Hawa Camara, Marie-Noëlle Delyfer, Emeline F. Nandrot, Jose-Alain Sahel, Olivier Goureau, Thierry Léveillard

Mol Ther. 2018 Jan 3; 26(1): 219–237. Published online 2017 Sep 8. doi: 10.1016/j.ymthe.2017.09.007

PMCID:: PMC5762984

Abstract Article PDF–6.3M

Select item 569302317.

Heterozygous mutation in OTX2 associated with early-onset retinal dystrophy with atypical maculopathy

Maram EA Abdalla-Elsayed, Patrik Schatz, Christine Neuhaus, Arif O. Khan

Mol Vis. 2017; 23: 778–784. Published online 2017 Nov 13.

PMCID:: PMC5693023

Abstract Article PDF–1.4M

Select item 534058718.

OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

Gaylor Boulay, Mary E. Awad, Nicolo Riggi, Tenley C. Archer, Sowmya Iyer, Wannaporn E. Boonseng, Nikki E Rossetti, Beverly Naigles, Shruthi Rengarajan, Angela Volorio, James C. Kim, Jill P. Mesirov, Pablo Tamayo, Scott L. Pomeroy, Martin J. Aryee, Miguel N. Rivera

Cancer Discov. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Cancer Discov. 2017 Mar; 7(3): 288–301. Published online 2017 Feb 17. doi: 10.1158/2159-8290.CD-16-0844

PMCID:: PMC5340587

Abstract Article PDF–810K

Select item 530426719.

OTX1 and OTX2 as Possible Molecular Markers of Sinonasal Carcinomas and Olfactory Neuroblastomas

Cristina Pirrone, Anna M. Chiaravalli, Alessandro Marando, Andrea Conti, Alessia Rainero, Andrea Pistochini, Francesco Lo Curto, Francesco Pasquali, Paolo Castelnuovo, Carlo Capella, Giovanni Porta

Eur J Histochem. 2017 Jan 23; 61(1): 2730. Published online 2017 Feb 9. doi: 10.4081/ejh.2017.2730

PMCID:: PMC5304267

Abstract Article PDF–252K

Select item 524230220.

Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF‐α

Thibaud Mathis, Michael Housset, Chiara Eandi, Fanny Beguier, Sara Touhami, Sacha Reichman, Sebastien Augustin, Pauline Gondouin, José‐Alain Sahel, Laurent Kodjikian, Olivier Goureau, Xavier Guillonneau, Florian Sennlaub

Aging Cell. 2017 Feb; 16(1): 173–182. Published online 2016 Sep 22. doi: 10.1111/acel.12540

PMCID:: PMC5242302

Abstract Article PDF–1.6M

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