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Select item 111706851.

AIM2 inflammasome regulated by the IFN‐γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease

Yue Zhao, Bin Liang, Shuyang Sheng, Chen Wang, Bingyu Jin, Xiaokang Zhang, Yating Cheng, Changxin Shen, Fang Zheng

Immun Inflamm Dis. 2024 Jun; 12(6): e1317. Published online 2024 Jun 13. doi: 10.1002/iid3.1317

PMCID:: PMC11170685

Abstract Article PDF–3.7M

Select item 111451352.

Cytosolic DNA sensor AIM2 promotes KRAS‐driven lung cancer independent of inflammasomes

Mohammad Alanazi, Teresa Weng, Louise McLeod, Linden J. Gearing, Julian A. Smith, Beena Kumar, Mohamed I. Saad, Brendan J. Jenkins

Cancer Sci. 2024 Jun; 115(6): 1834–1850. Published online 2024 Apr 9. doi: 10.1111/cas.16171

PMCID:: PMC11145135

Abstract Article PDF–8.0M

Select item 110886733.

Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1

Shujiang Zhuo, Sufei Song, Chaoyi Wang, Zhe Wang, Ming Zhang, Daobin Lin, Kaili Chen

Sci Rep. 2024; 14: 10782. Published online 2024 May 11. doi: 10.1038/s41598-024-61495-4

PMCID:: PMC11088673

Abstract Article PDF–3.3M

Select item 110839504.

Herpes Simplex Virus ICP27 Protein Inhibits AIM 2-Dependent Inflammasome Influencing Pro-Inflammatory Cytokines Release in Human Pigment Epithelial Cells (hTert-RPE 1)

Anna Caproni, Chiara Nordi, Riccardo Fontana, Martina Facchini, Sara Melija, Mariangela Pappadà, Mattia Buratto, Peggy Marconi

Int J Mol Sci. 2024 May; 25(9): 4608. Published online 2024 Apr 23. doi: 10.3390/ijms25094608

PMCID:: PMC11083950

Abstract Article PDF–3.6M

Select item 109528135.

The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome

Ruby E Dawson, Virginie Deswaerte, Alison C West, Ekimei Sun, Georgie Wray‐McCann, Thaleia Livis, Beena Kumar, Emiliana Rodriguez, Cem Gabay, Richard L Ferrero, Brendan J Jenkins

Immunol Cell Biol. 2023 May-Jun; 101(5): 444–457. Published online 2023 Apr 19. doi: 10.1111/imcb.12641

PMCID:: PMC10952813

Abstract Article PDF–1.7M

Select item 109297816.

急性脑梗死患者血浆中AIM2、IL-1β和IL-18的表达及意义

王强, 余丹, 梁霁, 程启慧, 周锋, 林海丽

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Feb 28; 46(2): 149–155. Chinese. doi: 10.11817/j.issn.1672-7347.2021.190662

PMCID:: PMC10929781

Abstract Article PDF–888K

Select item 107651217.

Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

ZHI ZHANG, XIAOSONG LI, YING ZHANG, HAO ZHU, ZHENGUO QIAO, YANG LU, XIUWEI MI, HUIHUA CAO, GENHAI SHEN, SONGBING HE

Oncol Res. 2024; 32(2): 353–360. Published online 2023 Dec 28. doi: 10.32604/or.2023.042986

PMCID:: PMC10765121

Abstract Article PDF–4.8M

Select item 107629668.

AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma

Hui-Wen Chiu, Hsin-Lun Lee, Hsun-Hua Lee, Hsiao-Wei Lu, Kent Yu-Hsien Lin, Yuan-Feng Lin, Che-Hsuan Lin

J Transl Med. 2024; 22: 13. Published online 2024 Jan 3. doi: 10.1186/s12967-023-04825-w

PMCID:: PMC10762966

Abstract Article PDF–9.1M

Select item 106175679.

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection

Yongqi Li, Yang Yang, Tianyang Li, Zhengmin Wang, Chunfeng Gao, Rilin Deng, Faxiang Ma, Xinyang Li, Licong Ma, Renyun Tian, Huiyi Li, Haizhen Zhu, Lei Zeng, Yanhang Gao, Guoyue Lv, Junqi Niu, Ian Nicholas Crispe, Zhengkun Tu

J Virol. 2023 Oct; 97(10): e01090-23. Published online 2023 Oct 3. doi: 10.1128/jvi.01090-23

PMCID:: PMC10617567

Abstract Article PDF–7.0M

Select item 1008567910.

Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors

Archit Garg, Christina M Stallings, Jungsan Sohn

Nucleic Acids Res. 2023 Apr 11; 51(6): 2574–2585. Published online 2023 Mar 2. doi: 10.1093/nar/gkad090

PMCID:: PMC10085679

Abstract Article PDF–2.5M

Select item 1000870011.

AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis

Qi Wang, Su Gao, Yi Shou, Yujie Jia, Zhihao Wei, Yuenan Liu, Jian Shi, Daojia Miao, Qi Miao, Chuanyi Zhao, Chenchen Liu, Hongmei Yang, Tianbo Xu, Xiaoping Zhang

Int J Biol Sci. 2023; 19(4): 1266–1283. Published online 2023 Feb 13. doi: 10.7150/ijbs.79853

PMCID:: PMC10008700

Abstract Article PDF–18M

Select item 992621912.

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes

Camila Marques-da-Silva, Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau, Lecia L. Pewe, Melanie J. Shears, Thirumala-Devi Kanneganti, Photini Sinnis, Dennis E. Kyle, Prajwal Gurung, John T. Harty, Samarchith P. Kurup

Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2): e2210181120. Published online 2023 Jan 3. doi: 10.1073/pnas.2210181120

PMCID:: PMC9926219

Abstract Article PDF–4.0M

Select item 988963913.

AIM2 and Psoriasis

Yuxi Zhang, Xiaoqing Xu, Hui Cheng, Fusheng Zhou

Front Immunol. 2023; 14: 1085448. Published online 2023 Jan 18. doi: 10.3389/fimmu.2023.1085448

PMCID:: PMC9889639

Abstract Article PDF–1.9M

Select item 980753014.

AIM2 upregulation promotes metastatic progression and PD‐L1 expression in lung adenocarcinoma

Jing‐Quan Zheng, Che‐Hsuan Lin, Hsun‐Hua Lee, Wei‐Ming Chang, Li‐Jie Li, Chia‐Yi Su, Kang‐Yun Lee, Hui‐Wen Chiu, Yuan‐Feng Lin

Cancer Sci. 2023 Jan; 114(1): 306–320. Published online 2022 Sep 29. doi: 10.1111/cas.15584

PMCID:: PMC9807530

Abstract Article PDF–23M

Select item 975097615.

dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury

Chintogtokh Baatarjav, Takanori Komada, Tadayoshi Karasawa, Naoya Yamada, Ariunaa Sampilvanjil, Takayoshi Matsumura, Masafumi Takahashi

Cell Death Differ. 2022 Dec; 29(12): 2487–2502. Published online 2022 Jun 23. doi: 10.1038/s41418-022-01033-9

PMCID:: PMC9750976

Abstract Article PDF–11M

Select item 955958516.

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

Yan Qin, Liuxian Pan, Tianyu Qin, Hanyi Ruan, Yujie Zhang, Yan Zhang, Jianli Li, Jianrong Yang, Wei Li

Front Immunol. 2022; 13: 998266. Published online 2022 Sep 29. doi: 10.3389/fimmu.2022.998266

PMCID:: PMC9559585

Abstract Article PDF–13M

Select item 945733417.

Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema

Saleela M. Ruwanpura, Louise McLeod, Lovisa F. Dousha, Huei J. Seow, Alison C. West, Alice J. West, Teresa Weng, Mohammad Alanazi, Martin MacDonald, Paul T. King, Philip G. Bardin, Cem Gabay, Dennis M. Klinman, Steven Bozinovski, Ross Vlahos, Gary P. Anderson, Stefan Rose-John, Mohamed I. Saad, Brendan J. Jenkins

Proc Natl Acad Sci U S A. 2022 Sep 6; 119(36): e2201494119. Published online 2022 Aug 29. doi: 10.1073/pnas.2201494119

PMCID:: PMC9457334

Abstract Article PDF–2.5M

Select item 944872818.

Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis

Xiao Su, Shigang Zhao, Yijun Song

Sci Rep. 2022; 12: 15123. Published online 2022 Sep 6. doi: 10.1038/s41598-022-19398-9

PMCID:: PMC9448728

Abstract Article PDF–1.5M

Select item 927754619.

Activation of the AIM2 Receptor in Circulating Cells of Post-COVID-19 Patients With Signs of Lung Fibrosis Is Associated With the Release of IL-1α, IFN-α and TGF-β

Chiara Colarusso, Michela Terlizzi, Angelantonio Maglio, Antonio Molino, Claudio Candia, Carolina Vitale, Philip M. Hansbro, Alessandro Vatrella, Aldo Pinto, Rosalinda Sorrentino

Front Immunol. 2022; 13: 934264. Published online 2022 Jun 29. doi: 10.3389/fimmu.2022.934264

PMCID:: PMC9277546

Abstract Article PDF–3.3M

Select item 926734520.

The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage

Chiara Rossi, Antonio Salvati, Mariarosaria Distaso, Daniela Campani, Francesco Raggi, Edoardo Biancalana, Domenico Tricò, Maurizia Rossana Brunetto, Anna Solini

Int J Mol Sci. 2022 Jul; 23(13): 7447. Published online 2022 Jul 4. doi: 10.3390/ijms23137447

PMCID:: PMC9267345

Abstract Article PDF–3.6M

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