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Select item 108745691.

The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer

Ailing Wang, Wei-sha Zheng, Zhen Luo, Lian Bai, Shi Zhang

J Transl Med. 2024; 22: 173. Published online 2024 Feb 18. doi: 10.1186/s12967-024-04995-1

PMCID:: PMC10874569

Abstract Article PDF–5.1M

Select item 99747322.

ADAR1/ZBP1 in innate immunity, cell death, and disease

Rajendra Karki, Thirumala-Devi Kanneganti

Trends Immunol. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Trends Immunol. 2023 Mar; 44(3): 201–216. Published online 2023 Jan 27. doi: 10.1016/j.it.2023.01.001

PMCID:: PMC9974732

Abstract Article PDF–1.1M

Select item 99468313.

Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis

Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, Tobias T. Schmidt, Laura Mainz, Sara Przetocka, Candy Haggblom, Nimesha Tadepalle, April Williams, Maxim N. Shokhirev, Semih C. Akincilar, Vinay Tergaonkar, Gerald S. Shadel, Jan Karlseder

Nature. 2023; 614(7949): 767–773. Published online 2023 Feb 8. doi: 10.1038/s41586-023-05710-8

PMCID:: PMC9946831

Abstract Article PDF–7.5M

Select item 98442024.

SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses

Shufen Li, Yulan Zhang, Zhenqiong Guan, Meidi Ye, Huiling Li, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Fan Zhang, Ben Lu, Peng Zhou, Ke Peng

Cell Res. 2023 Mar; 33(3): 201–214. Published online 2023 Jan 17. doi: 10.1038/s41422-022-00775-y

PMCID:: PMC9844202

Abstract Article PDF–6.5M

Select item 98221195.

ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications

Xin-yu Chen, Ying-hong Dai, Xin-xing Wan, Xi-min Hu, Wen-juan Zhao, Xiao-xia Ban, Hao Wan, Kun Huang, Qi Zhang, Kun Xiong

Molecules. 2023 Jan; 28(1): 52. Published online 2022 Dec 21. doi: 10.3390/molecules28010052

PMCID:: PMC9822119

Abstract Article PDF–1.8M

Select item 97645636.

Fusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis

Hui Liu, Yuxuan Liu, Wei Fan, Bing Fan

Cell Commun Signal. 2022; 20: 196. Published online 2022 Dec 20. doi: 10.1186/s12964-022-01005-z

PMCID:: PMC9764563

Abstract Article PDF–6.3M

Select item 97246717.

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen

EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839

PMCID:: PMC9724671

Abstract Article PDF–1.8M

Select item 93739278.

ADAR1 masks the cancer immunotherapeutic potential of ZBP1-driven necroptosis

Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M. Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A. Beg, Paul G. Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert, Siddharth Balachandran

Nature. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Nature. 2022 Jun; 606(7914): 594–602. Published online 2022 May 25. doi: 10.1038/s41586-022-04753-7

PMCID:: PMC9373927

Abstract Article PDF–4.1M

Select item 93339479.

Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

Heather Koehler, Samantha Cotsmire, Ting Zhang, Siddharth Balachandran, Jason W. Upton, Jeffery Langland, Daniel Kalman, Bertram L. Jacobs, Edward S. Mocarski

Cell Host Microbe. Author manuscript; available in PMC 2022 Jul 28.

Published in final edited form as: Cell Host Microbe. 2021 Aug 11; 29(8): 1266–1276.e5. Published online 2021 Jun 29. doi: 10.1016/j.chom.2021.05.009

PMCID:: PMC9333947

Abstract Article PDF–2.0M

Select item 888356810.

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

Haematologica. 2022 Mar 1; 107(3): 721–732. Published online 2021 Feb 18. doi: 10.3324/haematol.2020.274480

PMCID:: PMC8883568

Abstract Article PDF–1.9M

Select item 886711111.

TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination

Xiaoyan Wang, Jing Xiong, Diwei Zhou, Shanfeng Zhang, Li Wang, Qingqing Tian, Changming Li, Jie Liu, Yaping Wu, Junying Li, Jun Wang

J Biol Chem. 2022 Mar; 298(3): 101611. Published online 2022 Jan 20. doi: 10.1016/j.jbc.2022.101611

PMCID:: PMC8867111

Abstract Article PDF–4.0M

Select item 875318512.

Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells

Jamal Saada, Ryan J. McAuley, Michela Marcatti, Tony Zifeng Tang, Massoud Motamedi, Bartosz Szczesny

J Biol Chem. 2022 Jan; 298(1): 101523. Published online 2021 Dec 23. doi: 10.1016/j.jbc.2021.101523

PMCID:: PMC8753185

Abstract Article PDF–3.3M

Select item 864333213.

Viral Z-RNA triggers ZBP1-dependent cell death

Siddharth Balachandran, Edward S. Mocarski

Curr Opin Virol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Curr Opin Virol. 2021 Oct 21; 51: 134–140. Published online 2021 Oct 21. doi: 10.1016/j.coviro.2021.10.004

PMCID:: PMC8643332

Abstract Article PDF–549K

Select item 860394214.

AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense

SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur, Thirumala-Devi Kanneganti

Nature. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Nature. 2021 Sep; 597(7876): 415–419. Published online 2021 Sep 1. doi: 10.1038/s41586-021-03875-8

PMCID:: PMC8603942

Abstract Article PDF–7.4M

Select item 811352715.

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-gang Liu

Nat Commun. 2021; 12: 2666. Published online 2021 May 11. doi: 10.1038/s41467-021-23004-3

PMCID:: PMC8113527

Abstract Article PDF–7.3M

Select item 793938316.

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)

Balaji Banoth, Shraddha Tuladhar, Rajendra Karki, Bhesh Raj Sharma, Benoit Briard, Sannula Kesavardhana, Amanda Burton, Thirumala-Devi Kanneganti

J Biol Chem. 2020 Dec 25; 295(52): 18276–18283. Published online 2021 Jan 13. doi: 10.1074/jbc.RA120.015924

PMCID:: PMC7939383

Abstract Article PDF–1.0M

Select item 715375317.

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Ting Zhang, Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran

Cell. Author manuscript; available in PMC 2021 Mar 19.

Published in final edited form as: Cell. 2020 Mar 19; 180(6): 1115–1129.e13. doi: 10.1016/j.cell.2020.02.050

PMCID:: PMC7153753

Abstract Article PDF–3.8M

Select item 677813718.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9