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Select item 112714081.

METTL3-mediated N⁶-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4

Yichen Zang, Zhuangfei Tian, Dandan Wang, Yaxuan Li, Wenhui Zhang, Cunying Ma, Zhenzhi Liao, Wenrong Gao, Lilin Qian, Xia Xu, Jihui Jia, Zhifang Liu

Oncogene. 2024; 43(30): 2338–2354. Published online 2024 Jun 15. doi: 10.1038/s41388-024-03085-2

PMCID:: PMC11271408

Abstract Article PDF–7.9M

Select item 112586562.

Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma

Songhe Guo, Fangfang Chen, Linfang Li, Shuheng Dou, Qifan Li, Yuying Huang, Zijun Li, Wanli Liu, Ge Zhang

J Adv Res. 2024 Jul; 61: 165–178. Published online 2023 Aug 22. doi: 10.1016/j.jare.2023.08.014

PMCID:: PMC11258656

Abstract Article PDF–4.2M

Select item 112347093.

METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer

Tao Wang, Xu Li, Yue Tao, Xiaojun Wang, Limeng Li, Jianjun Liu

J Transl Med. 2024; 22: 643. Published online 2024 Jul 9. doi: 10.1186/s12967-024-05463-6

PMCID:: PMC11234709

Abstract Article PDF–11M

Select item 112342064.

METTL3 regulates thyroid cancer differentiation and chemosensitivity by modulating PAX8

Ning Kang, Zewei Zhao, Zhongyu Wang, Junya Ning, Huijuan Wang, Wei Zhang, Xianhui Ruan, Ming Gao, Xiangqian Zheng

Int J Biol Sci. 2024; 20(9): 3426–3441. Published online 2024 Jun 17. doi: 10.7150/ijbs.84797

PMCID:: PMC11234206

Abstract Article PDF–10M

Select item 111481845.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110897016.

N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension

Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, Qiang Su, Xiaoyun Liao, Jun Wang, Yanqin Niu, Cuilian Liu, Jinglin Tian, Deming Gou

Cell Mol Biol Lett. 2024; 29: 69. Published online 2024 May 13. doi: 10.1186/s11658-024-00590-w

PMCID:: PMC11089701

Abstract Article PDF–1.5M

Select item 110727557.

METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability

Huafu Li, Chunming Wang, Linxiang Lan, Leping Yan, Wuguo Li, Ian Evans, E. Josue Ruiz, Qiao Su, Guangying Zhao, Wenhui Wu, Haiyong Zhang, Zhijun Zhou, Zhenran Hu, Wei Chen, Joaquim M. Oliveira, Axel Behrens, Rui L. Reis, Changhua Zhang

Cell Mol Life Sci. 2022 Mar; 79(3): 135. Published online 2022 Feb 18. doi: 10.1007/s00018-022-04129-0

PMCID:: PMC11072755

Abstract Article PDF–9.6M

Select item 110426818.

Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni

Nat Cell Biol. Author manuscript; available in PMC 2024 Apr 24.

Published in final edited form as: Nat Cell Biol. 2024 Mar; 26(3): 421–437. Published online 2024 Feb 26. doi: 10.1038/s41556-024-01368-0

PMCID:: PMC11042681

Abstract Article PDF–8.2M

Select item 110079749.

METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis

Peng Ouyang, Kang Li, Wei Xu, Caiyun Chen, Yangdong Shi, Yao Tian, Jin Gong, Zhen Bao

J Exp Clin Cancer Res. 2024; 43: 111. Published online 2024 Apr 11. doi: 10.1186/s13046-024-03035-6

PMCID:: PMC11007974

Abstract Article PDF–6.8M

Select item 1095075010.

Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3

Guifang Li, Huan Liu, Yangmeng Yu, Qian Wang, Chen Yang, Yang Yan, Fang Wang, Yong Mao

eBioMedicine. 2024 Apr; 102: 105041. Published online 2024 Mar 13. doi: 10.1016/j.ebiom.2024.105041

PMCID:: PMC10950750

Abstract Article PDF–5.0M

Select item 1093274411.

METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN

Shujiang Chen, Xiaoqiong Duan, Yanjin He, Wenchuan Chen

Biosci Rep. 2024 Mar 29; 44(3): BSR20231186. Published online 2024 Mar 12. doi: 10.1042/BSR20231186

PMCID:: PMC10932744

Abstract Article PDF–1.5M

Select item 1092084212.

METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability

Xuefei Sun, Xiujiao Meng, Yu Piao, Shaojie Dong, Qianqian Dong

Int J Med Sci. 2024; 21(4): 664–673. Published online 2024 Feb 4. doi: 10.7150/ijms.90485

PMCID:: PMC10920842

Abstract Article PDF–3.5M

Select item 1090784613.

METTL3 as a novel diagnosis and treatment biomarker and its association with glycolysis, cuproptosis and ceRNA in oesophageal carcinoma

Xu‐Sheng Liu, Yu Zhang, Zi‐Yue Liu, Yan Gao, Ling‐Ling Yuan, Dao‐Bing Zeng, Fan Tan, Hua‐Bing Wan, Zhi‐Jun Pei

J Cell Mol Med. 2024 Mar; 28(6): e18195. Published online 2024 Mar 1. doi: 10.1111/jcmm.18195

PMCID:: PMC10907846

Abstract Article PDF–17M

Select item 1090601514.

METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy

Fangfang Wang, Juan Bai, Xin Zhang, Dali Wang, Xin Zhang, Jingwen Xue, Haoyang Chen, Shuxiang Wang, Baojin Chi, Jing Li, Xiaoru Ma

J Diabetes Investig. 2024 Mar; 15(3): 288–299. Published online 2023 Nov 28. doi: 10.1111/jdi.14113

PMCID:: PMC10906015

Abstract Article PDF–3.8M

Select item 1086644915.

Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner

Yuanzhen Chen, Ping Li, Mei Lin, Ying Jiang, Guiping Tan, Lianfang Huang, Dan Song

Aging (Albany NY) 2024 Jan 31; 16(2): 1237–1248. Published online 2024 Jan 29. doi: 10.18632/aging.205401

PMCID:: PMC10866449

Abstract Article PDF–1.2M

Select item 1084534016.

The RNA m⁶A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications

Weiqi Su, Lin Che, Wenting Liao, Huilin Huang

Front Immunol. 2024; 15: 1335774. Published online 2024 Jan 22. doi: 10.3389/fimmu.2024.1335774

PMCID:: PMC10845340

Abstract Article PDF–1.7M

Select item 1083461617.

METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke

Wenjie Su, Xiang Yu, Shan Wang, Xu Wang, Zheng Dai, Yi Li

Cell Biol Toxicol. 2024; 40(1): 8. Published online 2024 Feb 2. doi: 10.1007/s10565-024-09844-x

PMCID:: PMC10834616

Abstract Article PDF–7.0M

Select item 1079417118.

METTL3 facilitates renal cell carcinoma progression by PLOD2 m⁶A-methylation under prolonged hypoxia

Yimeng Chen, Yichen He, Zhengsheng Li, Nan Zhang, Cuixing Zhou, Xiaozhou He, Dong Xue

Cell Death Dis. 2024 Jan; 15(1): 62. Published online 2024 Jan 17. doi: 10.1038/s41419-023-06411-w

PMCID:: PMC10794171

Abstract Article PDF–4.5M

Select item 1078690719.

FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation

Kai Chen, Yue Wang, Xingna Dai, Jingjing Luo, Shangshang Hu, Zhihui Zhou, Jinglong Shi, Xueshan Pan, Tong Cao, Jun Xia, Yuyun Li, Zhiwei Wang, Jia Ma

Cell Death Dis. 2024 Jan; 15(1): 37. Published online 2024 Jan 12. doi: 10.1038/s41419-024-06425-y

PMCID:: PMC10786907

Abstract Article PDF–5.1M

Select item 1078394320.

Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)

Chiyun Shao, Yanjie Han, Yuying Huang, Zhe Zhang, Tao Gong, Yajie Zhang, Xiaokang Tian, Mingzhi Fang, Xuan Han, Min Li

Int J Oncol. 2024 Feb; 64(2): 17. Published online 2023 Dec 19. doi: 10.3892/ijo.2023.5605

PMCID:: PMC10783943

Abstract Article PDF–3.3M

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PMC Links for GEO Profiles (Select 115367254) (227)
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Tremor, Hereditary Essential, And Idiopathic Normal Pressure Hydrocephalus [Supp...
Tremor, Hereditary Essential, And Idiopathic Normal Pressure Hydrocephalus [Supplementary Concept]
Date introduced: November 5, 2012<br/>

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MeSH for MedGen (Select 394839) (1)
MeSH
txid34277[Organism] (112999)
Protein
Desulfovibrio bizertensis DSM 18034 genome assembly, contig: BR26DRAFT_scaffold0...
Desulfovibrio bizertensis DSM 18034 genome assembly, contig: BR26DRAFT_scaffold00022.22, whole genome shotgun sequence
gi|1152129619|emb|FUYA01000022.1|

Nucleotide

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