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Select item 112194301.

OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination

Liqun Peng, Tiangen Wu, Yingyi Liu, Dongli Zhao, Wenzhi He, Yufeng Yuan

Cell Oncol (Dordr) 2024; 47(3): 987–1004. Published online 2024 Feb 5. doi: 10.1007/s13402-023-00913-7

PMCID:: PMC11219430

Abstract Article PDF–8.4M

Select item 111663422.

OTUB1 contributes to the stability and function of Influenza A virus NS2

Yu-Jyun Li, Chi-Yuan Chen, Yu-Shen Kuo, Yi-Wen Huang, Rei-Lin Kuo, Li-Kwan Chang, Jeng-How Yang, Chih-Ho Lai, Shin-Ru Shih, Ya-Fang Chiu

PLoS Pathog. 2024 May; 20(5): e1012279. Published online 2024 May 30. doi: 10.1371/journal.ppat.1012279

PMCID:: PMC11166342

Abstract Article PDF–2.7M

Select item 111094833.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110023134.

YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation

Xuefeng Zhao, Suli Lv, Neng Li, Qingli Zou, Lidong Sun, Tanjing Song

J Biol Chem. 2024 Apr; 300(4): 107152. Published online 2024 Mar 9. doi: 10.1016/j.jbc.2024.107152

PMCID:: PMC11002313

Abstract Article PDF–2.8M

Select item 107570955.

Involvement of the OTUB1‐YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma

Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi, Naozumi Ishimaru, Yasusei Kudo

Cancer Med. 2023 Dec; 12(24): 22156–22169. Published online 2023 Nov 20. doi: 10.1002/cam4.6735

PMCID:: PMC10757095

Abstract Article PDF–3.3M

Select item 104449716.

OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6

Ying Zhao, Jing Ruan, Zhongding Li, Xian Su, Kangmin Chen, Yimin Lin, Yuepiao Cai, Peng Wang, Baohua Liu, Dirk Schlüter, Guang Liang, Xu Wang

Clin Transl Med. 2023 Aug; 13(8): e1385. Published online 2023 Aug 22. doi: 10.1002/ctm2.1385

PMCID:: PMC10444971

Abstract Article PDF–6.0M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101252598.

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura

Nat Chem Biol. Author manuscript; available in PMC 2023 Apr 24.

Published in final edited form as: Nat Chem Biol. 2022 Apr; 18(4): 412–421. Published online 2022 Feb 24. doi: 10.1038/s41589-022-00971-2

PMCID:: PMC10125259

Abstract Article PDF–2.8M

Select item 100798389.

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Qiong Zhu, Yesheng Fu, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu, Lingqiang Zhang

Signal Transduct Target Ther. 2023; 8: 142. Published online 2023 Apr 7. doi: 10.1038/s41392-023-01354-2

PMCID:: PMC10079838

Abstract Article PDF–5.3M

Select item 1004087610.

SET7 methylates the deubiquitinase OTUB1 at Lys ¹²² to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis

Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu

J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054

PMCID:: PMC10040876

Abstract Article PDF–3.0M

Select item 989602411.

Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer

Li Liao, Yin-Ling Zhang, Ling Deng, Chao Chen, Xiao-Yan Ma, Lisa Andriani, Shao-Ying Yang, Shu-Yuan Hu, Fang-Lin Zhang, Zhi-Min Shao, Da-Qiang Li

Cancer Res. 2023 Feb 3; 83(3): 471–484. Published online 2022 Dec 9. doi: 10.1158/0008-5472.CAN-22-2709

PMCID:: PMC9896024

Abstract Article PDF–17M

Select item 988326112.

Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor

Seung Un Seo, Seon Min Woo, Min Wook Kim, Eun-Woo Lee, Kyoung-jin Min, Taeg Kyu Kwon

Cell Death Differ. 2023 Jan; 30(1): 82–93. Published online 2022 Aug 4. doi: 10.1038/s41418-022-01047-3

PMCID:: PMC9883261

Abstract Article PDF–4.6M

Select item 981605913.

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou

Oncogene. 2023; 42(2): 83–98. Published online 2022 Nov 12. doi: 10.1038/s41388-022-02537-x

PMCID:: PMC9816059

Abstract Article PDF–7.6M

Select item 979335914.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w

PMCID:: PMC9793359

Abstract Article PDF–3.7M

Select item 976969815.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 970052116.

OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer

Cheng Yan, Huijie Yang, Peng Su, Xin Li, Zhongbo Li, Dehai Wang, Yifeng Zang, Tianshi Wang, Ziping Liu, Zhuocong Bao, Shuxiao Dong, Ting Zhuang, Jian Zhu, Yinlu Ding

Oncogene. 2022; 41(48): 5186–5198. Published online 2022 Oct 21. doi: 10.1038/s41388-022-02507-3

PMCID:: PMC9700521

Abstract Article PDF–5.4M

Select item 962668817.

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis

Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu

iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363

PMCID:: PMC9626688

Abstract Article PDF–6.0M

Select item 948160218.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner

Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1

PMCID:: PMC9481602

Abstract Article PDF–3.7M

Select item 943337219.

Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis

Xue Han, Chune Ren, Chao Lu, Pengyun Qiao, Tingting Yang, Zhenhai Yu

Cell Death Differ. 2022 Sep; 29(9): 1864–1873. Published online 2022 Mar 16. doi: 10.1038/s41418-022-00971-8

PMCID:: PMC9433372

Abstract Article PDF–7.3M

Select item 937779720.

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu

eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247

PMCID:: PMC9377797

Abstract Article PDF–4.9M

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PMC Links for GEO Profiles (Select 116775528) (150)
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txid90964[Organism] (207206)
BioSample
PREDICTED: Homo sapiens mitogen-activated protein kinase kinase kinase 15 (MAP3K...
PREDICTED: Homo sapiens mitogen-activated protein kinase kinase kinase 15 (MAP3K15), transcript variant X5, mRNA
gi|1034674281|ref|XM_011545511.2|

Nucleotide

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