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Items: 1 to 20 of 32

1.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
2.
Point Mutations of Nicotinic Receptor α1 Subunit Reveal New Molecular Features of G153S Slow-Channel Myasthenia
Denis Kudryavtsev, Anastasia Isaeva, Daria Barkova, Ekaterina Spirova, Renata Mukhutdinova, Igor Kasheverov, Victor Tsetlin
Molecules. 2021 Mar; 26(5): 1278. Published online 2021 Feb 26. doi: 10.3390/molecules26051278
PMCID:
PMC7956382
AbstractArticlePDF–5.0M
3.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
4.
Slow-Channel Myasthenic Syndrome Caused By Enhanced Activation, Desensitization, and Agonist Binding Affinity Attributable to Mutation in the M2 Domain of the Acetylcholine Receptor α Subunit
Margherita Milone, Hai-Long Wang, Kinji Ohno, Takayasu Fukudome, J. Ned Pruitt, Nina Bren, Steven M. Sine, Andrew G. Engel
J Neurosci. 1997 Aug 1; 17(15): 5651–5665. doi: 10.1523/JNEUROSCI.17-15-05651.1997
PMCID:
PMC6573201
AbstractArticlePDF–950K
5.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
6.
High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor
Paul J. Groot-Kormelink, Sandrine Ferrand, Nicholas Kelley, Anke Bill, Felix Freuler, Pierre-Eloi Imbert, Anthony Marelli, Nicole Gerwin, Lucia G. Sivilotti, Loren Miraglia, Anthony P. Orth, Edward J. Oakeley, Ulrich Schopfer, Sandra Siehler
PLoS One. 2016; 11(9): e0163129. Published online 2016 Sep 20. doi: 10.1371/journal.pone.0163129
PMCID:
PMC5029940
AbstractArticlePDF–2.1M
7.
Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components
Jessica Oyola-Cintrón, Daniel Caballero-Rivera, Leomar Ballester, Carlos A. Baéz-Pagán, Hernán L. Martínez, Karla P. Vélez-Arroyo, Orestes Quesada, José A. Lasalde-Dominicci
J Biol Chem. 2015 Oct 30; 290(44): 26790–26800. Published online 2015 Sep 9. doi: 10.1074/jbc.M115.678573
PMCID:
PMC4646332
AbstractArticlePDF–1.1M
8.
Expression of a Highly Antigenic and Native-Like Folded Extracellular Domain of the Human α1 Subunit of Muscle Nicotinic Acetylcholine Receptor, Suitable for Use in Antigen Specific Therapies for Myasthenia Gravis
Athanasios Niarchos, Marios Zouridakis, Vassilis Douris, Assimina Georgostathi, Dimitra Kalamida, Alexandros Sotiriadis, Konstantinos Poulas, Kostas Iatrou, Socrates J. Tzartos
PLoS One. 2013; 8(12): e84791. Published online 2013 Dec 20. doi: 10.1371/journal.pone.0084791
PMCID:
PMC3869910
AbstractArticlePDF–613K
9.
HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
Mohammad Alinoor Rahman, Akio Masuda, Kenji Ohe, Mikako Ito, David O. Hutchinson, Akila Mayeda, Andrew G. Engel, Kinji Ohno
Sci Rep. 2013; 3: 2931. Published online 2013 Oct 14. doi: 10.1038/srep02931
PMCID:
PMC3796306
AbstractArticlePDF–2.2M
10.
Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans
Kyle M. Walsh, Christopher I. Amos, Angela S. Wenzlaff, Ivan P. Gorlov, Jennette D. Sison, Xifeng Wu, Margaret R. Spitz, Helen M. Hansen, Emily Y. Lu, Chongjuan Wei, Huifeng Zhang, Wei Chen, Stacy M. Lloyd, Marsha L. Frazier, Paige M. Bracci, Michael F. Seldin, Margaret R. Wrensch, Ann G. Schwartz, John K. Wiencke
Oncotarget. 2012 Nov; 3(11): 1428–1438. Published online 2012 Nov 16. doi: 10.18632/oncotarget.746
PMCID:
PMC3717803
AbstractArticlePDF–858K
11.
Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating
Xin-Ming Shen, Joan M. Brengman, Steven M. Sine, Andrew G. Engel
J Clin Invest. 2012 Jul 2; 122(7): 2613–2621. Published online 2012 Jun 25. doi: 10.1172/JCI63415
PMCID:
PMC3386830
AbstractArticlePDF–1.0M
12.
Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy
Guoqiang Zhang, Alison L Thomas, Amanda L Marshall, Kelly A Kernan, Yanyuan Su, Yi Zheng, Jiro Takano, Takaomi C Saido, Allison A Eddy
Lab Invest. Author manuscript; available in PMC 2011 Oct 6.
Published in final edited form as: Lab Invest. 2011 Jan; 91(1): 106–123. Published online 2010 Jul 26. doi: 10.1038/labinvest.2010.135
PMCID:
PMC3188436
AbstractArticlePDF–2.0M
13.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
14.
A large-scale candidate-gene association study of age at menarche and age at natural menopause
Chunyan He, Peter Kraft, Daniel I. Chasman, Julie E. Buring, Constance Chen, Susan E. Hankinson, Guillaume Paré, Stephen Chanock, Paul M. Ridker, David J. Hunter
Hum Genet. Author manuscript; available in PMC 2010 Nov 1.
Published in final edited form as: Hum Genet. 2010 Nov; 128(5): 515–527. Published online 2010 Aug 24. doi: 10.1007/s00439-010-0878-4
PMCID:
PMC2967297
AbstractArticlePDF–84K
15.
Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study
Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators
Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452
PMCID:
PMC2945168
AbstractArticlePDF–153K
16.
Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score
Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl
Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159
Correction in:
Mol Med. 2012; 18(1): 729.
PMCID:
PMC2896464
AbstractArticlePDF–2.4M
17.
Association of CHRN genes with “dizziness” to tobacco
Marissa A. Ehringer, Matthew B. McQueen, Nicole R. Hoft, Nancy Saccone, Jerry Stitzel, Jen C. Wang, Laura J. Bierut
Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2011 Mar 5.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5; 153B(2): 600–609. doi: 10.1002/ajmg.b.31027
PMCID:
PMC2878135
AbstractArticlePDF–542K
18.
Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani
Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014
PMCID:
PMC2775832
AbstractArticlePDF–2.8M
19.
Multiple Distinct Risk Loci for Nicotine Dependence Identified by Dense Coverage of the Complete Family of Nicotinic Receptor Subunit (CHRN) Genes
Nancy L. Saccone, Scott F. Saccone, Anthony L. Hinrichs, Jerry A. Stitzel, Weimin Duan, Michele L. Pergadia, Arpana Agrawal, Naomi Breslau, Richard A. Grucza, Dorothy Hatsukami, Eric O. Johnson, Pamela A. F. Madden, Gary E. Swan, Jen C. Wang, Alison M. Goate, John P. Rice, Laura J. Bierut
Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2010 Jun 5.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5; 150B(4): 453–466. doi: 10.1002/ajmg.b.30828
PMCID:
PMC2693307
AbstractArticlePDF–1.6M
20.
Examination of the Nicotine Dependence (NICSNP) Consortium findings in the Iowa adoption studies population
Robert A. Philibert, Alexandre Todorov, Allan Andersen, Nancy Hollenbeck, Tracy Gunter, Andrew Heath, Pamela Madden
Nicotine Tob Res. 2009 Mar; 11(3): 286–292. Published online 2009 Mar 23. doi: 10.1093/ntr/ntn034
PMCID:
PMC2666378
AbstractArticlePDF–118K

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