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Select item 112275061.

Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia

Jing Liang, Yang Wan, Jie Gao, Lingyue Zheng, Jingwei Wang, Peng Wu, Yue Li, Bingrui Wang, Ding Wang, Yige Ma, Biao Shen, Xue Lv, Di Wang, Na An, Xiaoli Ma, Guangfeng Geng, Jingyuan Tong, Jinhua Liu, Guo Chen, Meng Gao, Ryo Kurita, Yukio Nakamura, Ping Zhu, Hang Yin, Xiaofan Zhu, Lihong Shi

Nat Commun. 2024; 15: 5678. Published online 2024 Jul 6. doi: 10.1038/s41467-024-50066-w

PMCID:: PMC11227506

Abstract Article PDF–3.5M

Select item 105062122.

TLR8 escapes X chromosome inactivation in human monocytes and CD4⁺ T cells

Ali Youness, Claire Cenac, Berenice Faz-López, Solange Grunenwald, Franck J. Barrat, Julie Chaumeil, José Enrique Mejía, Jean-Charles Guéry

Biol Sex Differ. 2023; 14: 60. Published online 2023 Sep 18. doi: 10.1186/s13293-023-00544-5

PMCID:: PMC10506212

Abstract Article PDF–2.9M

Select item 104778513.

CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis

Xiaodong Xu, Shuang Qu, Changming Zhang, Mingchao Zhang, Weisong Qin, Guisheng Ren, Hao Bao, Limin Li, Ke Zen, Zhihong Liu

Adv Sci (Weinh) 2023 Sep; 10(25): 2301492. Published online 2023 Jul 3. doi: 10.1002/advs.202301492

PMCID:: PMC10477851

Abstract Article PDF–5.2M

Select item 103724074.

Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice

Naomi I Maria, Julien Papoin, Chirag Raparia, Zeguo Sun, Rachel Josselsohn, Ailing Lu, Hani Katerji, Mahrukh M Syeda, David Polsky, Robert Paulson, Theodosia Kalfa, Betsy J Barnes, Weijia Zhang, Lionel Blanc, Anne Davidson

Life Sci Alliance. 2023 Oct; 6(10): e202302241. Published online 2023 Jul 26. doi: 10.26508/lsa.202302241

PMCID:: PMC10372407

Abstract Article PDF–3.7M

Select item 98654295.

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

Marie Dominique Ah Kioon, Claudio Tripodo, David Fernandez, Kyriakos A. Kirou, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Franck J. Barrat

Sci Transl Med. Author manuscript; available in PMC 2023 Jan 21.

Published in final edited form as: Sci Transl Med. 2018 Jan 10; 10(423): eaam8458. doi: 10.1126/scitranslmed.aam8458

PMCID:: PMC9865429

Abstract Article PDF–2.3M

Select item 96177316.

Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling

Chalystha Yie Qin Lee, Yee Teng Chan, Yi Ying Cheok, Grace Min Yi Tan, Ting Fang Tang, Heng Choon Cheong, Jamuna Vadivelu, Suhailah Abdullah, Chung Yeng Looi, Won Fen Wong

J Immunol Res. 2022; 2022: 3861518. Published online 2022 Oct 22. doi: 10.1155/2022/3861518

PMCID:: PMC9617731

Abstract Article PDF–1.1M

Select item 95538367.

TLR-8, TNF-α, and ESR-1α Gene Polymorphism Susceptibility in Onset of Arthritis

Maryam Mukhtar, Nadeem Sheikh, Andleeb Batool, Tayyaba Saleem, Muhammad Babar Khawar, Mavra Irfan, Saira Kainat Suqaina

Genet Res (Camb) 2022; 2022: 9208765. Published online 2022 Sep 20. doi: 10.1155/2022/9208765

PMCID:: PMC9553836

Abstract Article PDF–474K

Select item 94790928.

Gain-of-function defects in toll-like receptor 8 shed light on the interface between immune system and bone marrow failure disorders

Jack Bleesing

Front Immunol. 2022; 13: 935321. Published online 2022 Sep 2. doi: 10.3389/fimmu.2022.935321

PMCID:: PMC9479092

Abstract Article PDF–1.5M

Select item 91954029.

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

Chao Yang, Mahesh Bachu, Yong Du, Caroline Brauner, Ruoxi Yuan, Marie Dominique Ah Kioon, Giancarlo Chesi, Franck J. Barrat, Lionel B. Ivashkiv

Nat Commun. 2022; 13: 3426. Published online 2022 Jun 14. doi: 10.1038/s41467-022-31132-7

PMCID:: PMC9195402

Abstract Article PDF–3.4M

Select item 881444410.

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8

Hannah-Lena Obermann, Ines I. Lederbogen, Jenny Steele, Jens Dorna, Leif Erik Sander, Konrad Engelhardt, Udo Bakowsky, Andreas Kaufmann, Stefan Bauer

Front Immunol. 2021; 12: 658895. Published online 2022 Jan 21. doi: 10.3389/fimmu.2021.658895

PMCID:: PMC8814444

Abstract Article PDF–5.2M

Select item 851155111.

Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteins

Subhajit Dasgupta, Mausumi Bandyopadhyay

Med Hypotheses. 2021 Dec; 157: 110706. Published online 2021 Oct 13. doi: 10.1016/j.mehy.2021.110706

PMCID:: PMC8511551

Abstract Article PDF–3.5M

Select item 831636912.

Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands

Ruben Serrano, Christoph Coch, Christian Peters, Gunther Hartmann, Daniela Wesch, Dieter Kabelitz

Sci Rep. 2021; 11: 15231. Published online 2021 Jul 27. doi: 10.1038/s41598-021-94428-6

PMCID:: PMC8316369

Abstract Article PDF–1.8M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810901314.

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function

Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena A. Walkiewicz, Christopher D. Putnam, Marwan Shinawi, Nermina Saucier, Elise M. Rizzi, Michael T. Harmon, Molly P. Keppel, Michelle Ritter, Morgan Similuk, Elaine Kulm, Michael Joyce, Adriana A. de Jesus, Raphaela Goldbach-Mansky, Yi-Shan Lee, Marina Cella, Peggy L. Kendall, Mary C. Dinauer, Jeffrey J. Bednarski, Christina Bemrich-Stolz, Scott W. Canna, Shirley M. Abraham, Matthew M. Demczko, Jonathan Powell, Stacie M. Jones, Amy M. Scurlock, Suk See De Ravin, Jack J. Bleesing, James A. Connelly, V. Koneti Rao, Laura G. Schuettpelz, Megan A. Cooper

Blood. 2021 May 6; 137(18): 2450–2462. Prepublished online 2020 Dec 23. doi: 10.1182/blood.2020009620

PMCID:: PMC8109013

Abstract Article

Select item 806802515.

Successful Direct Acting Antiviral Therapy in Chronic Hepatitis C Normalizes IFNγ and IL2 Production in T Cells Together with TLR8 Expression and Functionality in Peripheral Blood Mononuclear Cells

María Teresa Arias-Loste, Joaquín Cabezas, Susana Llerena, Paula Iruzubieta, David San-Segundo, David Merino, Antonio Cuadrado, José Pedro Vaqué, Marcos López-Hoyos, Javier Crespo

Viruses. 2021 Apr; 13(4): 635. Published online 2021 Apr 7. doi: 10.3390/v13040635

PMCID:: PMC8068025

Abstract Article PDF–10M

Select item 793999416.

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

Grant R. Campbell, Rachel K. To, Jonathan Hanna, Stephen A. Spector

iScience. 2021 Apr 23; 24(4): 102295. Published online 2021 Mar 9. doi: 10.1016/j.isci.2021.102295

PMCID:: PMC7939994

Abstract Article PDF–3.7M

Select item 793366917.

STAT3 Silencing and TLR7/8 Pathway Activation Repolarize and Suppress Myeloid-Derived Suppressor Cells From Breast Cancer Patients

Elham Safarzadeh, Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Shahryar Hashemzadeh, Vahid Khaze, Tohid Kazemi, Afshin Derakhshani, Nicola Silvestris, Behzad Baradaran

Front Immunol. 2020; 11: 613215. Published online 2021 Feb 19. doi: 10.3389/fimmu.2020.613215

PMCID:: PMC7933669

Abstract Article PDF–4.3M

Select item 779082018.

Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4⁺ Treg cells in ovarian cancer cells microenvironment

Rui Xu, Ming Wu, Shuna Liu, Wenwen Shang, Rong Li, Juan Xu, Lei Huang, Fang Wang

Cell Death Dis. 2021 Jan; 12(1): 22. Published online 2021 Jan 7. doi: 10.1038/s41419-020-03272-5

PMCID:: PMC7790820

Abstract Article PDF–1.4M

Select item 769404419.

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico

Araceli Posadas-Mondragón, José Leopoldo Aguilar-Faisal, Gerardo Zuñiga, Jonathan Javier Magaña, José Angel Santiago-Cruz, Edith Guillén-Salomón, Verónica Alcántara-Farfán, María Luisa Arellano-Flores, Juan Santiago Salas-Benito, Rocío M. Neri-Bazán, Lucero Luna-Rojas, Amanda Marineth Avila-Trejo, Adolfo Chávez-Negrete

Viruses. 2020 Nov; 12(11): 1230. Published online 2020 Oct 29. doi: 10.3390/v12111230