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Select item 112489961.

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals

Fangfang Lu, Hongtu Zhao, Yaxin Dai, Yingdi Wang, Chia-Hsueh Lee, Matthew Freeman

Mol Cell. 2024 Jun 6; 84(11): 2152–2165.e5. doi: 10.1016/j.molcel.2024.04.025

PMCID:: PMC11248996

Abstract Article PDF–6.6M

Select item 109910582.

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Matteo Calligaris, Donatella P. Spanò, Simone Bonelli, Stephan A. Müller, Claudia Carcione, Danilo D’apolito, Giandomenico Amico, Monica Miele, Mariangela Di Bella, Giovanni Zito, Elisa Nuti, Armando Rossello, Carl P. Blobel, Stefan F. Lichtenthaler, Simone D. Scilabra

Cell Mol Life Sci. 2024 Dec; 81(1): 163. Published online 2024 Apr 4. doi: 10.1007/s00018-024-05201-7

PMCID:: PMC10991058

Abstract Article PDF–5.6M

Select item 105586573.

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Yi Zhang, Fufeng Gao, Xianling Dai, Qin Kuang, Jie Chai, Benkui Zou, Bochu Wang

Adv Sci (Weinh) 2023 Oct; 10(28): 2302130. Published online 2023 Aug 6. doi: 10.1002/advs.202302130

Correction in:: Adv Sci (Weinh). 2023 Dec; 10(36): 2308024.

PMCID:: PMC10558657

Abstract Article PDF–8.2M

Select item 101533464.

Hanjuan Gong, Hailun Xie, Zhimin Huangfu, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Yalan Wang

FEBS Open Bio. 2023 May; 13(5): 881–897. Published online 2023 Apr 5. doi: 10.1002/2211-5463.13598

PMCID:: PMC10153346

Abstract Article PDF–5.3M

Select item 100312795.

The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Wei Dong, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Jing Feng, Bochu Wang

Acta Pharm Sin B. 2023 Mar; 13(3): 1071–1092. Published online 2022 Dec 12. doi: 10.1016/j.apsb.2022.12.006

PMCID:: PMC10031279

Abstract Article PDF–8.1M

Select item 94823486.

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Boris Sieber, Fangfang Lu, Stephen M. Stribbling, Adam G. Grieve, Anderson J. Ryan, Matthew Freeman

J Cell Sci. 2022 Sep 1; 135(17): jcs259949. Published online 2022 Sep 8. doi: 10.1242/jcs.259949

PMCID:: PMC9482348

Abstract Article

Select item 93173807.

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress

Yangwenshu Liu, Qin Kuang, Xianling Dai, Minxia Zhan, Li Zhou, Liancai Zhu, Bochu Wang

Int J Mol Sci. 2022 Jul; 23(14): 7701. Published online 2022 Jul 12. doi: 10.3390/ijms23147701

PMCID:: PMC9317380

Abstract Article PDF–6.2M

Select item 92626148.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91082609.

Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

Taylor J. Louis, Ahmad Qasem, Saleh A. Naser

Front Immunol. 2022; 13: 887830. Published online 2022 May 2. doi: 10.3389/fimmu.2022.887830

PMCID:: PMC9108260

Abstract Article PDF–3.7M

Select item 888160910.

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang

Nat Commun. 2022; 13: 1052. Published online 2022 Feb 25. doi: 10.1038/s41467-022-28641-w

PMCID:: PMC8881609

Abstract Article PDF–7.5M

Select item 868842011.

Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells

Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Gross, Pavel Strnad, Stefan Düsterhöft, Andreas Ludwig

Sci Rep. 2021; 11: 24230. Published online 2021 Dec 20. doi: 10.1038/s41598-021-03522-2

PMCID:: PMC8688420

Abstract Article PDF–2.3M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 787838313.

The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner

Joseph Skurski, Garima Dixit, Carl P. Blobel, Priya D. Issuree, Thorsten Maretzky

Front Cell Infect Microbiol. 2020; 10: 620392. Published online 2021 Jan 29. doi: 10.3389/fcimb.2020.620392

PMCID:: PMC7878383

Abstract Article PDF–3.0M

Select item 750328014.

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner

Anke Seifert, Justyna Wozniak, Stefan Düsterhöft, Petr Kasparek, Radislav Sedlacek, Stephan Dreschers, Thorsten W. Orlikowsky, Daniela Yildiz, Andreas Ludwig

Int J Mol Sci. 2020 Sep; 21(17): 5978. Published online 2020 Aug 19. doi: 10.3390/ijms21175978

PMCID:: PMC7503280

Abstract Article PDF–2.6M

Select item 732206715.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 723983216.

iRhom2 in the pathogenesis of oral squamous cell carcinoma

Matthew E. Agwae, Richard J. Shaw, Asterios Triantafyllou, Frances S. T. Greaney, Khaled Ben Salah, Janet M. Risk

Mol Biol Rep. 2020; 47(5): 3987–3992. Published online 2020 Mar 31. doi: 10.1007/s11033-020-05381-y

PMCID:: PMC7239832

Abstract Article PDF–900K

Select item 720246617.

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

Sathish K. Maney, David R. McIlwain, Robin Polz, Aleksandra A. Pandyra, Balamurugan Sundaram, Dorit Wolff, Kazuhito Ohishi, Thorsten Maretzky, Matthew A. Brooke, Astrid Evers, Ananda A. Jaguva Vasudevan, Nima Aghaeepour, Jürgen Scheller, Carsten Münk, Dieter Häussinger, Tak W. Mak, Garry P. Nolan, David P. Kelsell, Carl P. Blobel, Karl S. Lang, Philipp A. Lang

Sci Signal. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: Sci Signal. 2015 Nov 3; 8(401): ra109. Published online 2015 Nov 3. doi: 10.1126/scisignal.aac5356

PMCID:: PMC7202466

Abstract Article PDF–1.2M

Select item 696943418.

De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance

Zi-Yuan Nie, Min Yao, Zhan Yang, Lin Yang, Xiao-Jun Liu, Jing Yu, Ying Ma, Nan Zhang, Xiao-Yan Zhang, Meng-Han Liu, Ling-Ling Jiang, Jian-Min Luo

J Exp Clin Cancer Res. 2020; 39: 17. Published online 2020 Jan 17. doi: 10.1186/s13046-019-1502-7

PMCID:: PMC6969434

Abstract Article PDF–2.4M

Select item 690894019.

Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways

Qin Xu, Chuanben Chen, Bin Liu, Yibin Lin, Peng Zheng, Dongmei Zhou, Yunqing Xie, Ya Lin, Ciren Guo, Jing Liu, Li Li

Oncol Rep. 2020 Jan; 43(1): 41–54. Published online 2019 Oct 25. doi: 10.3892/or.2019.7389

PMCID:: PMC6908940

Abstract Article PDF–1011K

Select item 666388020.

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4

Kyojiro N. Ikeda, Matthew Freeman

J Biol Chem. 2019 Jul 26; 294(30): 11486–11497. Published online 2019 Jun 7. doi: 10.1074/jbc.RA118.007074

PMCID:: PMC6663880

Abstract Article PDF–2.0M

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