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Select item 95095661.

A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection

Xiaoyan Xu, Guangmei Zheng, Yushan Ren, Xiaohua He, Biwen Peng, Xuemei Hu, Wanhong Liu

Parasit Vectors. 2022; 15: 337. Published online 2022 Sep 24. doi: 10.1186/s13071-022-05455-9

PMCID:: PMC9509566

Abstract Article PDF–6.5M

Select item 70948712.

Sepsis Erodes CD8⁺ Memory T Cell Protective Immunity Against an EBV Homolog in a 2B4-Dependent Manner

J Xie, RL Crepeau, CW Chen, W Zhang, S Otani, CM Coopersmith, ML Ford

J Leukoc Biol. Author manuscript; available in PMC 2020 Mar 25.

Published in final edited form as: J Leukoc Biol. 2019 Mar; 105(3): 565–575. Published online 2019 Jan 9. doi: 10.1002/JLB.4A0718-292R

PMCID:: PMC7094871

Abstract Article PDF–955K

Select item 69488543.

2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy

Ching-wen Chen, Ming Xue, Wenxiao Zhang, Jianfeng Xie, Craig M. Coopersmith, Mandy L. Ford

JCI Insight. 2019 Nov 14; 4(22): e127867. Published online 2019 Nov 14. doi: 10.1172/jci.insight.127867

PMCID:: PMC6948854

Abstract Article PDF–12M

Select item 65383604.

Increased attrition of memory T cells during sepsis requires 2B4

Jianfeng Xie, Ching-wen Chen, Yini Sun, Sonia J. Laurie, Wenxiao Zhang, Shunsuke Otani, Gregory S. Martin, Craig M. Coopersmith, Mandy L. Ford

JCI Insight. 2019 May 2; 4(9): e126030. Published online 2019 May 2. doi: 10.1172/jci.insight.126030

PMCID:: PMC6538360

Abstract Article PDF–2.2M

Select item 61038055.

2B4 Mediates Inhibition of CD8⁺ T Cell Responses via Attenuation of Glycolysis and Cell Division

Sonia J. Laurie, Danya Liu, Maylene E. Wagener, Phoebe E. Stark, Cox Terhorst, Mandy L. Ford

J Immunol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: J Immunol. 2018 Sep 1; 201(5): 1536–1548. Published online 2018 Jul 16. doi: 10.4049/jimmunol.1701240

PMCID:: PMC6103805

Abstract Article PDF–977K

Select item 58906516.

Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens

Allison Cabinian, Daniel Sinsimer, May Tang, Youngsoon Jang, Bongkum Choi, Yasmina Laouar, Amale Laouar

Gut. 2018 May; 67(5): 847–859. Published online 2017 Mar 24. doi: 10.1136/gutjnl-2016-313214

PMCID:: PMC5890651

Abstract Article PDF–2.1M

Select item 55874007.

2B4-mediated coinhibition of CD4⁺ T cells underlies mortality in experimental sepsis

Ching-wen Chen, Rohit Mittal, Nathan J. Klingensmith, Eileen M. Burd, Cox Terhorst, Greg S. Martin, Craig M. Coopersmith, Mandy L. Ford

J Immunol. Author manuscript; available in PMC 2018 Sep 15.

Published in final edited form as: J Immunol. 2017 Sep 15; 199(6): 1961–1966. Published online 2017 Aug 2. doi: 10.4049/jimmunol.1700375

PMCID:: PMC5587400

Abstract Article PDF–1.1M

Select item 55652688.

SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin

Jun Chen, Ming-Chao Zhong, Huaijian Guo, Dominique Davidson, Sabrin Mishel, Yan Lu, Inmoo Rhee, Luis-Alberto Pérez-Quintero, Shaohua Zhang, Mario-Ernesto Cruz-Munoz, Ning Wu, Donald C. Vinh, Meenal Sinha, Virginie Calderon, Clifford A. Lowell, Jayne S. Danska, André Veillette

Nature. Author manuscript; available in PMC 2017 Aug 21.

Published in final edited form as: Nature. 2017 Apr 27; 544(7651): 493–497. Published online 2017 Apr 19. doi: 10.1038/nature22076

PMCID:: PMC5565268

Abstract Article PDF–5.4M

Select item 50308099.

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1

Huaijian Guo, Stacey A. Cranert, Yan Lu, Ming-Chao Zhong, Shaohua Zhang, Jun Chen, Rui Li, Sarah E. Mahl, Ning Wu, Dominique Davidson, Stephen N. Waggoner, André Veillette

J Exp Med. 2016 Sep 19; 213(10): 2187–2207. doi: 10.1084/jem.20160552

Correction in:: J Exp Med. 2016 Sep 19; 213(10): 2227.

PMCID:: PMC5030809

Abstract Article PDF–4.3M

Select item 455498710.

2B4 Is Dispensable for T-Dependent B Cell Immune Responses, but Its Deficiency Leads to Enhanced T-Independent Responses Due to an Increase in Peritoneal Cavity B1b Cells

Avijit Ray, Cheng-Yin Yuan, Nichole M. Miller, Hong Mei, Bonnie N. Dittel

PLoS One. 2015; 10(8): e0137314. Published online 2015 Aug 31. doi: 10.1371/journal.pone.0137314

PMCID:: PMC4554987

Abstract Article PDF–989K

Select item 447672911.

Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression

Danya Liu, Suzanne J. Suchard, Steve G. Nadler, Mandy L. Ford

PLoS One. 2015; 10(6): e0130490. Published online 2015 Jun 22. doi: 10.1371/journal.pone.0130490

PMCID:: PMC4476729

Abstract Article PDF–2.9M

Select item 440951612.

SLAMF4 is a Negative Regulator of Expansion of Cytotoxic Intra-epithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine

Michael S. O’Keeffe, Joo-Hye Song, Gongxian Liao, Jaime De Calisto, Peter J. Halibozek, J. Rodrigo Mora, Atul K. Bhan, Ninghai Wang, Hans-Christian Reinecker, Cox Terhorst

Gastroenterology. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Gastroenterology. 2015 May; 148(5): 991–1001.e4. Published online 2015 Feb 10. doi: 10.1053/j.gastro.2015.02.003

PMCID:: PMC4409516

Abstract Article PDF–1.9M

Select item 425666813.

Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells

Tae-Jin Kim, Miju Kim, Hye Mi Kim, Seon Ah Lim, Eun-Ok Kim, Kwanghee Kim, Kwang Hoon Song, Jiyoung Kim, Vinay Kumar, Cassian Yee, Junsang Doh, Kyung-Mi Lee

Sci Rep. 2014; 4: 7157. Published online 2014 Dec 5. doi: 10.1038/srep07157

PMCID:: PMC4256668

Abstract Article PDF–2.4M

Select item 392056514.

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8⁺ T cell responses

Danya Liu, Scott M. Krummey, I. Raul Badell, Maylene Wagener, Lumelle A. Schneeweis, Dawn K. Stetsko, Suzanne J. Suchard, Steven G. Nadler, Mandy L. Ford

J Exp Med. 2014 Feb 10; 211(2): 297–311. doi: 10.1084/jem.20130902

PMCID:: PMC3920565

Abstract Article PDF–3.7M

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 348974116.

An ENU mutagenesis approach to dissect “self”-induced immune responses: Unraveling the genetic footprint of immunosurveillance

Siobhan Cashman, Kristin Lampe, Rachel Sheridan, Kasper Hoebe

Oncoimmunology. 2012 Sep 1; 1(6): 856–862. doi: 10.4161/onci.20580

PMCID:: PMC3489741

Abstract Article PDF–773K

Select item 343429817.

Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function

Chia-Ling Tu, Debra Crumrine, Mao-Qiang Man, Wenhan Chang, Hashem Elalieh, Michael You, Peter M. Elias, Daniel D. Bikle

J Invest Dermatol. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: J Invest Dermatol. 2012 Oct; 132(10): 2350–2359. Published online 2012 May 24. doi: 10.1038/jid.2012.159

PMCID:: PMC3434298

Abstract Article PDF–2.8M

Select item 338913318.

Positive and Negative Signaling through SLAM receptors regulate Synapse Organization and Thresholds of Cytolysis

Fang Zhao, Jennifer L. Cannons, Mala Dutta, Gillian M. Griffiths, Pamela L. Schwartzberg

Immunity. Author manuscript; available in PMC 2013 Jun 29.

Published in final edited form as: Immunity. 2012 Jun 29; 36(6): 1003–1016. Published online 2012 Jun 7. doi: 10.1016/j.immuni.2012.05.017

PMCID:: PMC3389133

Abstract Article PDF–4.4M

Select item 325555419.

The adapters EAT-2A and -2B are positive regulators of CD244 and CD84 dependent NK cell functions in the C57BL/6 mouse

Ninghai Wang, Silvia Calpe, Jill Westcott, Wilson Castro, Chunyan Ma, Pablo Engel, John Schatzle, Cox Terhorst

J Immunol. Author manuscript; available in PMC 2012 Jan 11.

Published in final edited form as: J Immunol. 2010 Nov 15; 185(10): 5683–5687. Published online 2010 Oct 20. doi: 10.4049/jimmunol.1001974

PMCID:: PMC3255554

Abstract Article PDF–653K

Select item 324198220.

Tight Regulation of Memory CD8 T Cells Limits Their Effectiveness during Sustained High Viral Load

Erin E. West, Ben Youngblood, Wendy G. Tan, Hyun-Tak Jin, Koichi Araki, Gabriela Alexe, Bogumila T. Konieczny, Silvia Calpe, Gordon J. Freeman, Cox Terhorst, W. Nicholas Haining, Rafi Ahmed

Immunity. Author manuscript; available in PMC 2012 Aug 26.

Published in final edited form as: Immunity. 2011 Aug 26; 35(2): 285–298. doi: 10.1016/j.immuni.2011.05.017