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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 98817294.

The FANCJ Helicase Unfolds DNA-Protein Cross-Links to Promote Their Repair

Denitsa Yaneva, Justin L. Sparks, Maximilian Donsbach, Shubo Zhao, Pedro Weickert, Rachel Bezalel-Buch, Julian Stingele, Johannes C. Walter

Mol Cell. Author manuscript; available in PMC 2024 Jan 5.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 43–56.e10. doi: 10.1016/j.molcel.2022.12.005

PMCID:: PMC9881729

Abstract Article PDF–1.2M

Select item 98677495.

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

Pedro Weickert, Hao-Yi Li, Maximilian J. Götz, Sophie Dürauer, Denitsa Yaneva, Shubo Zhao, Jacqueline Cordes, Aleida C. Acampora, Ignasi Forne, Axel Imhof, Julian Stingele

Nat Commun. 2023; 14: 352. Published online 2023 Jan 21. doi: 10.1038/s41467-023-35988-1

PMCID:: PMC9867749

Abstract Article PDF–5.4M

Select item 91273656.

Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN

Alexander Kröning, Johannes van den Boom, Matthias Kracht, Anja F. Kueck, Hemmo Meyer

J Biol Chem. 2022 Jun; 298(6): 101976. Published online 2022 Apr 22. doi: 10.1016/j.jbc.2022.101976

PMCID:: PMC9127365

Abstract Article PDF–1.1M

Select item 87690727.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 86745358.

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

Annamaria Ruggiano, Bruno Vaz, Susan Kilgas, Marta Popović, Gonzalo Rodriguez-Berriguete, Abhay N. Singh, Geoff S. Higgins, Anne E. Kiltie, Kristijan Ramadan

Cell Rep. 2021 Dec 7; 37(10): 110080. Published online 2021 Dec 7. doi: 10.1016/j.celrep.2021.110080

PMCID:: PMC8674535

Abstract Article

Select item 85019619.

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes

Liton Kumar Saha, Yasuhisa Murai, Sourav Saha, Ukhyun Jo, Masataka Tsuda, Shunichi Takeda, Yves Pommier

Nucleic Acids Res. 2021 Oct 11; 49(18): 10493–10506. Published online 2021 Sep 22. doi: 10.1093/nar/gkab777

PMCID:: PMC8501961

Abstract Article PDF–4.1M

Select item 823607810.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796055012.

USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease

Megan Perry, Meghan Biegert, Sai Sundeep Kollala, Halle Mallard, Grace Su, Manohar Kodavati, Natasha Kreiling, Alexander Holbrook, Gargi Ghosal

J Biol Chem. 2021 Jan-Jun; 296: 100396. Published online 2021 Feb 7. doi: 10.1016/j.jbc.2021.100396

PMCID:: PMC7960550

Abstract Article PDF–1.5M

Select item 787081813.

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer, Anne E. Kiltie

Cell Death Dis. 2021 Feb; 12(2): 165. Published online 2021 Feb 8. doi: 10.1038/s41419-021-03437-w

PMCID:: PMC7870818

Abstract Article PDF–3.1M

Select item 782625114.

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN

Shubo Zhao, Anja Kieser, Hao-Yi Li, Hannah K Reinking, Pedro Weickert, Simon Euteneuer, Denitsa Yaneva, Aleida C Acampora, Maximilian J Götz, Regina Feederle, Julian Stingele

Nucleic Acids Res. 2021 Jan 25; 49(2): 902–915. Published online 2020 Dec 22. doi: 10.1093/nar/gkaa1224

PMCID:: PMC7826251

Abstract Article PDF–2.3M

Select item 753479815.

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

Hannah K. Reinking, Hyun-Seo Kang, Maximilian J. Götz, Hao-Yi Li, Anja Kieser, Shubo Zhao, Aleida C. Acampora, Pedro Weickert, Evelyn Fessler, Lucas T. Jae, Michael Sattler, Julian Stingele

Mol Cell. 2020 Oct 1; 80(1): 102–113.e6. doi: 10.1016/j.molcel.2020.08.003

PMCID:: PMC7534798

Abstract Article

Select item 748410416.

Tandem deubiquitination and acetylation of SPRTN promotes DNA-protein crosslinks repair and protects against aging

Jinzhou Huang, Qin Zhou, Ming Gao, Somaira Nowsheen, Fei Zhao, Wootae Kim, Qian Zhu, Yusuke Kojima, Ping Yin, Yong Zhang, Guijie Guo, Xinyi Tu, Min Deng, Kuntian Luo, Bo Qin, Yuichi Machida, Zhenkun Lou

Mol Cell. Author manuscript; available in PMC 2021 Sep 3.

Published in final edited form as: Mol Cell. 2020 Sep 3; 79(5): 824–835.e5. Published online 2020 Jul 9. doi: 10.1016/j.molcel.2020.06.027

PMCID:: PMC7484104

Abstract Article PDF–2.1M

Select item 706275117.

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan

Nat Commun. 2020; 11: 1274. Published online 2020 Mar 9. doi: 10.1038/s41467-020-15000-w

PMCID:: PMC7062751

Abstract Article PDF–3.7M

Select item 572549418.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr

Nat Commun. 2017; 8: 2039. Published online 2017 Dec 11. doi: 10.1038/s41467-017-02146-3

PMCID:: PMC5725494

Abstract Article PDF–4.0M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 538963520.

DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA

Mónika Mórocz, Eszter Zsigmond, Róbert Tóth, Márton Zs Enyedi, Lajos Pintér, Lajos Haracska

Nucleic Acids Res. 2017 Apr 7; 45(6): 3172–3188. Published online 2017 Jan 2. doi: 10.1093/nar/gkw1315

PMCID:: PMC5389635

Abstract Article PDF–2.6M

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