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Select item 111677951.

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West

Mol Neurodegener. 2024; 19: 47. Published online 2024 Jun 11. doi: 10.1186/s13024-024-00738-4

PMCID:: PMC11167795

Abstract Article PDF–5.2M

Select item 111370132.

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in model

Andrea Wetzel, Si Hang Lei, Tiansheng Liu, Michael P. Hughes, Yunan Peng, Tristan McKay, Simon N. Waddington, Simone Grannò, Ahad A. Rahim, Kirsten Harvey

Sci Rep. 2024; 14: 12393. Published online 2024 May 29. doi: 10.1038/s41598-024-63130-8

PMCID:: PMC11137013

Abstract Article PDF–13M

Select item 110963883.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson’s disease

Ping Fang, Lewis W. Yu, Hannah Espey, Gulistan Agirman, Sabeen A. Kazmi, Kai Li, Yongning Deng, Jamie Lee, Haley Hrncir, Arlene Romero-Lopez, Arthur P. Arnold, Elaine Y. Hsiao

Commun Biol. 2024; 7: 570. Published online 2024 May 15. doi: 10.1038/s42003-024-06256-9

PMCID:: PMC11096388

Abstract Article PDF–4.6M

Select item 110840374.

Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice

Dan Li, Shu-fang Yu, Lin Lin, Jie-ru Guo, Si-mei Huang, Xi-lin Wu, Han-lin You, Xiao-juan Cheng, Qiu-yang Zhang, Yu-qi Zeng, Xiao-dong Pan

J Neuroinflammation. 2024; 21: 123. Published online 2024 May 9. doi: 10.1186/s12974-024-03125-4

PMCID:: PMC11084037

Abstract Article PDF–3.8M

Select item 110117035.

LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation

Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang

Cells. 2024 Apr; 13(7): 565. Published online 2024 Mar 23. doi: 10.3390/cells13070565

PMCID:: PMC11011703

Abstract Article PDF–6.0M

Select item 109623126.

The Parkinson’s disease kinase LRRK2 coordinates a cell intrinsic defense pathway against the intracellular pathogen Salmonella

Huan Lian, Donghyun Park, Meixin Chen, Florian Schueder, Maria Lara-Tejero, Jun Liu, Jorge E. Galán

Nat Microbiol. Author manuscript; available in PMC 2024 Mar 25.

Published in final edited form as: Nat Microbiol. 2023 Oct; 8(10): 1880–1895. Published online 2023 Aug 28. doi: 10.1038/s41564-023-01459-y

PMCID:: PMC10962312

Abstract Article PDF–5.5M

Select item 109487807.

Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking

Daniel da Silva, Aya Matsui, Erin M. Murray, Adamantios Mamais, Michael E. Authement, Jung Hoon Shin, Marlisa Shaw, Dorit Ron, Mark R. Cookson, Veronica A. Alvarez

Neuropsychopharmacology. 2024 Apr; 49(5): 824–836. Published online 2023 Sep 8. doi: 10.1038/s41386-023-01731-z

PMCID:: PMC10948780

Abstract Article PDF–5.0M

Select item 109176608.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109107839.

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson

Transl Neurodegener. 2024; 13: 13. Published online 2024 Mar 4. doi: 10.1186/s40035-024-00403-2

PMCID:: PMC10910783

Abstract Article PDF–15M

Select item 1090696510.

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2

Dylan J. Dues, Yue Ma, An Phu Tran Nguyen, Alina V. Offerman, Ian Beddows, Darren J. Moore

Neurobiol Dis. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Neurobiol Dis. 2023 Nov; 188: 106338. Published online 2023 Oct 29. doi: 10.1016/j.nbd.2023.106338

PMCID:: PMC10906965

Abstract Article PDF–3.9M

Select item 1070889011.

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

Herschel S Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R Alessi, Suzanne R Pfeffer

eLife. 2023; 12: e87098. Published online 2023 Oct 24. doi: 10.7554/eLife.87098

PMCID:: PMC10708890

Abstract Article PDF–8.8M

Select item 1069910412.

LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes

Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa

FEBS Open Bio. 2023 Dec; 13(12): 2200–2214. Published online 2023 Oct 26. doi: 10.1002/2211-5463.13717

PMCID:: PMC10699104

Abstract Article PDF–8.2M

Select item 1061437813.

LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity

Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera

Cell Commun Signal. 2023; 21: 300. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01305-y

PMCID:: PMC10614378

Abstract Article PDF–1.3M

Select item 1060255014.

LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF‐β1 in Parkinson's Disease

Longping Yao, Fengfei Lu, Sumeyye Koc, Zijian Zheng, Baoyan Wang, Shizhong Zhang, Thomas Skutella, Guohui Lu

Adv Sci (Weinh) 2023 Oct; 10(30): 2303711. Published online 2023 Sep 6. doi: 10.1002/advs.202303711

PMCID:: PMC10602550

Abstract Article PDF–8.0M

Select item 1055190115.

Endogenous Rab38 regulates LRRK2’s membrane recruitment and substrate Rab phosphorylation in melanocytes

Alexandra Unapanta, Farbod Shavarebi, Jacob Porath, Yiyi Shen, Carson Balen, Albert Nguyen, Josh Tseng, Weng Si Leong, Michelle Liu, Pawel Lis, Santiago M. Di Pietro, Annie Hiniker

J Biol Chem. 2023 Oct; 299(10): 105192. Published online 2023 Aug 23. doi: 10.1016/j.jbc.2023.105192

PMCID:: PMC10551901

Abstract Article PDF–4.1M

Select item 1047042016.

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen

Redox Biol. 2023 Oct; 66: 102860. Published online 2023 Aug 22. doi: 10.1016/j.redox.2023.102860