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Select item 99130751.

Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription

Lisa Oelschläger, Paul Stahl, Farnusch Kaschani, Roland H. Stauber, Shirley K. Knauer, Astrid Hensel

Cells. 2023 Feb; 12(3): 363. Published online 2023 Jan 18. doi: 10.3390/cells12030363

PMCID:: PMC9913075

Abstract Article PDF–5.3M

Select item 97725582.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 92626143.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 87489584.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 83356855.

Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR‐515‐5p/HMGA2 axis

Yuanyuan Lin, Yan Huang, Changda Liang, Shupei Xie, An Xie

J Cell Mol Med. 2021 Aug; 25(15): 7367–7380. Published online 2021 Jul 1. doi: 10.1111/jcmm.16765

PMCID:: PMC8335685

Abstract Article PDF–2.8M

Select item 81050976.

TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway

Xue-Mei Wan, Xue-Lei Zhou, Yong-Jun Du, Hui Shen, Zhengxia Yang, Yanhong Ding

J Immunol Res. 2021; 2021: 5521325. Published online 2021 Apr 29. doi: 10.1155/2021/5521325

PMCID:: PMC8105097

Abstract Article PDF–2.3M

Select item 79104597.

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams

Nat Commun. 2021; 12: 1302. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21478-9

PMCID:: PMC7910459

Abstract Article PDF–3.3M

Select item 73200438.

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation

Bethany Mason, Susanne Flach, Felipe R. Teixeira, Raquel Manzano Garcia, Oscar M. Rueda, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards, Heike Laman

Cell Mol Life Sci. 2020 Jul; 77(13): 2605–2620. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03306-y

PMCID:: PMC7320043

Abstract Article PDF–2.5M

Select item 70191409.

TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway

Yijian Zhang, Pengcheng Du, Yang Li, Qin Zhu, Xiaoling Song, Shibo Liu, Jiaqi Hao, Liguo Liu, Fatao Liu, Yunping Hu, Lin Jiang, Qiang Ma, Wei Lu, Yingbin Liu

Int J Biol Sci. 2020; 16(5): 739–751. Published online 2020 Jan 14. doi: 10.7150/ijbs.40516

PMCID:: PMC7019140

Abstract Article PDF–3.0M

Select item 674682210.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 629936811.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 582692612.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 566832313.

Disease-relevant signalling-pathways in head and neck cancer: Taspase1’s proteolytic activity fine-tunes TFIIA function

Alena Gribko, Angelina Hahlbrock, Sebastian Strieth, Sven Becker, Jan Hagemann, Max Deichelbohrer, Andreas Hildebrandt, Negusse Habtemichael, D. Wünsch

Sci Rep. 2017; 7: 14937. Published online 2017 Nov 2. doi: 10.1038/s41598-017-14814-x

PMCID:: PMC5668323

Abstract Article PDF–4.0M

Select item 490535714.

Taspase 1: A protease with many biological surprises

Hidetaka Niizuma, Emily H Cheng, James J Hsieh

Mol Cell Oncol. 2015 Oct-Dec; 2(4): e999513. Published online 2015 Jan 23. doi: 10.1080/23723556.2014.999513

PMCID:: PMC4905357

Abstract Article PDF–169K

Select item 458135915.

Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID

Barbora Malecová, Valentina S Caputo, Diane F Lee, James J Hsieh, Thomas Oelgeschläger

Transcription. 2015 Mar-Apr; 6(2): 21–32. Published online 2015 May 21. doi: 10.1080/21541264.2015.1052178

PMCID:: PMC4581359

Abstract Article PDF–605K

Select item 448619516.

Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein

Samaneh Sabiani, Tim Geppert, Christian Engelbrecht, Eric Kowarz, Gisbert Schneider, Rolf Marschalek

EBioMedicine. 2015 May; 2(5): 386–395. Published online 2015 Apr 16. doi: 10.1016/j.ebiom.2015.04.009

PMCID:: PMC4486195

Abstract Article PDF–1.9M

Select item 338916417.

Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1

D Wünsch, V Fetz, D Heider, S Tenzer, C Bier, L Kunst, S Knauer, R Stauber

Blood Cancer J. 2012 Jun; 2(6): e77. Published online 2012 Jun 29. doi: 10.1038/bcj.2012.22

PMCID:: PMC3389164

Article PDF–250K

Select item 334304618.

Overexpression of the Catalytically Impaired Taspase1^T234V or Taspase1^D233A Variants Does Not Have a Dominant Negative Effect in T(4;11) Leukemia Cells

Carolin Bier, Rouven Hecht, Lena Kunst, Sabine Scheiding, Désirée Wünsch, Dorothée Goesswein, Günter Schneider, Oliver H. Krämer, Shirley K. Knauer, Roland H. Stauber

PLoS One. 2012; 7(5): e34142. Published online 2012 May 3. doi: 10.1371/journal.pone.0034142

PMCID:: PMC3343046

Abstract Article PDF–630K

Select item 319082619.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907