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Select item 109679301.

The Binding of the SARS-CoV-2 Spike Protein to Platelet Factor 4: A Proposed Mechanism for the Generation of Pathogenic Antibodies

Thi-Huong Nguyen, Li-Yu Chen, Nida Zaman Khan, Annerose Lindenbauer, Van-Chien Bui, Peter F. Zipfel, Doris Heinrich

Biomolecules. 2024 Mar; 14(3): 245. Published online 2024 Feb 20. doi: 10.3390/biom14030245

PMCID:: PMC10967930

Abstract Article PDF–2.1M

Select item 108622352.

PF4 activates the c-Mpl–Jak2 pathway in platelets

Richard J. Buka, Samantha J. Montague, Luis A. Moran, Eleyna M. Martin, Alexandre Slater, Steve P. Watson, Phillip L. R. Nicolson

Blood. 2024 Jan 4; 143(1): 64–69. Published online 2023 Oct 29. doi: 10.1182/blood.2023020872

PMCID:: PMC10862235

Abstract Article

Select item 107572193.

Platelet factor 4 induces bone loss by inhibiting the integrin α5‐FAK‐ERK pathway

Wei Li, Qiwei Zhang, Ranli Gu, Lijun Zeng, Hao Liu

Animal Model Exp Med. 2023 Dec; 6(6): 573–584. Published online 2023 Aug 11. doi: 10.1002/ame2.12342

PMCID:: PMC10757219

Abstract Article PDF–40M

Select item 107213214.

Platelet factor 4 limits neutrophil extracellular trap– and cell-free DNA–induced thrombogenicity and endothelial injury

Anh T.P. Ngo, Abigail Skidmore, Jenna Oberg, Irene Yarovoi, Amrita Sarkar, Nate Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

JCI Insight. 2023 Nov 22; 8(22): e171054. Published online 2023 Nov 22. doi: 10.1172/jci.insight.171054

PMCID:: PMC10721321

Abstract Article PDF–1.1M

Select item 99924505.

Platelet-instructed SPP1⁺ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann

Cell Rep. 2023 Feb 28; 42(2): 112131. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112131

PMCID:: PMC9992450

Abstract Article

Select item 98206496.

CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells

Immacolata Pietraforte, Alessia Butera, Lucia Gaddini, Anna Mennella, Raffaella Palazzo, Doriana Campanile, Katia Stefanantoni, Valeria Riccieri, Roberto Lande, Loredana Frasca

Int J Mol Sci. 2023 Jan; 24(1): 653. Published online 2022 Dec 30. doi: 10.3390/ijms24010653

PMCID:: PMC9820649

Abstract Article PDF–2.8M

Select item 96337747.

Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts

Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim

Sci Rep. 2022; 12: 18636. Published online 2022 Nov 3. doi: 10.1038/s41598-022-19850-w

PMCID:: PMC9633774

Abstract Article PDF–1.8M

Select item 96188218.

High levels of PF4, VEGF-A, and classical monocytes correlate with the platelets count and inflammation during active tuberculosis

Alexia Urbán-Solano, Julio Flores-Gonzalez, Alfredo Cruz-Lagunas, Gloria Pérez-Rubio, Ivette Buendia-Roldan, Lucero A. Ramón-Luing, Leslie Chavez-Galan

Front Immunol. 2022; 13: 1016472. Published online 2022 Oct 17. doi: 10.3389/fimmu.2022.1016472

PMCID:: PMC9618821

Abstract Article PDF–4.8M

Select item 92043409.

Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

Samar A. Soliman, Anam Haque, Kamala Vanarsa, Ting Zhang, Faten Ismail, Kyung Hyun Lee, Claudia Pedroza, Larry A. Greenbaum, Sherene Mason, M. John Hicks, Scott E. Wenderfer, Chandra Mohan

Front Immunol. 2022; 13: 885307. Published online 2022 May 26. doi: 10.3389/fimmu.2022.885307

PMCID:: PMC9204340

Abstract Article PDF–3.0M

Select item 919540210.

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

Chao Yang, Mahesh Bachu, Yong Du, Caroline Brauner, Ruoxi Yuan, Marie Dominique Ah Kioon, Giancarlo Chesi, Franck J. Barrat, Lionel B. Ivashkiv

Nat Commun. 2022; 13: 3426. Published online 2022 Jun 14. doi: 10.1038/s41467-022-31132-7

PMCID:: PMC9195402

Abstract Article PDF–3.4M

Select item 917638211.

Thrombospondin-1, Platelet Factor 4, and Galectin-1 are Associated with Engraftment in Patients with Sickle Cell Disease Who Underwent Haploidentical HSCT

Ahmad Shaikh, Purevdorj B. Olkhanud, Arunakumar Gangaplara, Abdoul Kone, Sajni Patel, Marjan Gucek, Courtney D. Fitzhugh

Transplant Cell Ther. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Transplant Cell Ther. 2022 May; 28(5): 249.e1–249.e13. Published online 2022 Feb 4. doi: 10.1016/j.jtct.2022.01.027

PMCID:: PMC9176382

Abstract Article PDF–1.3M

Select item 877547812.

Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells

Dawid M. Kaczor, Rafael Kramann, Tilman M. Hackeng, Leon J. Schurgers, Rory R. Koenen

Int J Mol Sci. 2022 Jan; 23(2): 580. Published online 2022 Jan 6. doi: 10.3390/ijms23020580

PMCID:: PMC8775478

Abstract Article PDF–4.1M

Select item 868842213.

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

Lucía Sanjurjo, Iris A. Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C. M. Castricum, Tanja D. De Gruijl, Ulf J. Nilsson, Hakon Leffler, Arjan W. Griffioen, Latifa Elantak, Rory R. Koenen, Victor L. J. L. Thijssen

Commun Biol. 2021; 4: 1415. Published online 2021 Dec 20. doi: 10.1038/s42003-021-02922-4

PMCID:: PMC8688422

Abstract Article PDF–2.7M

Select item 839531614.

Interactions of Spike-RBD of SARS-CoV-2 and Platelet Factor 4: New Insights in the Etiopathogenesis of Thrombosis

Margherita Passariello, Cinzia Vetrei, Felice Amato, Claudia De Lorenzo

Int J Mol Sci. 2021 Aug; 22(16): 8562. Published online 2021 Aug 9. doi: 10.3390/ijms22168562

PMCID:: PMC8395316

Abstract Article PDF–9.5M

Select item 830503315.

Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells

Annemiek Dickhout, Dawid M. Kaczor, Alexandra C. A. Heinzmann, Sanne L. N. Brouns, Johan W. M. Heemskerk, Marc A. M. J. van Zandvoort, Rory R. Koenen

Int J Mol Sci. 2021 Jul; 22(14): 7332. Published online 2021 Jul 8. doi: 10.3390/ijms22147332

PMCID:: PMC8305033

Abstract Article PDF–4.4M

Select item 829239816.

CD8⁺ T cells inhibit metastasis and CXCL4 regulates its function

Robiya Joseph, Rama Soundararajan, Suhas Vasaikar, Fei Yang, Kendra L. Allton, Lin Tian, Petra den Hollander, Sevinj Isgandarova, Monika Haemmerle, Barbara Mino, Tieling Zhou, Crystal Shin, Melisa Martinez-Paniagua, Aysegul A. Sahin, Jaime Rodriguez-Canales, Juri Gelovani, Jeffrey T. Chang, Ghanashyam Acharya, Anil K. Sood, Ignacio I. Wistuba, Don L. Gibbons, Luisa M. Solis, Michelle C. Barton, Navin Varadarajan, Jeffrey M. Rosen, Xiang H. Zhang, Sendurai A. Mani

Br J Cancer. 2021 Jul 20; 125(2): 176–189. Published online 2021 Apr 1. doi: 10.1038/s41416-021-01338-5

PMCID:: PMC8292398

Abstract Article PDF–4.1M

Select item 823959517.

The complicated relationships of heparin‐induced thrombocytopenia and platelet factor 4 antibodies with COVID‐19

Emmanuel J. Favaloro, Brandon Michael Henry, Giuseppe Lippi

Int J Lab Hematol. 2021 Aug; 43(4): 547–558. Published online 2021 May 17. doi: 10.1111/ijlh.13582

PMCID:: PMC8239595

Abstract Article PDF–1.0M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011