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Items: 1 to 20 of 41

1.
Correlation between choline kinase alpha expression and 11C-choline accumulation in breast cancer using positron emission tomography/computed tomography: a retrospective study
Akane Ozawa, Masako Iwasaki, Kota Yokoyama, Junichi Tsuchiya, Ryutaro Kawano, Hiroshi Nishihara, Ukihide Tateishi
Sci Rep. 2023; 13: 17620. Published online 2023 Oct 17. doi: 10.1038/s41598-023-44542-4
PMCID:
PMC10582087
AbstractArticlePDF–1.4M
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation
Qingxia Ma, Hongfei Jiang, Leina Ma, Gaoxiang Zhao, Qianqian Xu, Dong Guo, Ningning He, Hao Liu, Zhaoyuan Meng, Juanjuan Liu, Lei Zhu, Qian Lin, Xiaolin Wu, Min Li, Shudi Luo, Jing Fang, Zhimin Lu
Proc Natl Acad Sci U S A. 2023 Apr 11; 120(15): e2209435120. Published online 2023 Apr 3. doi: 10.1073/pnas.2209435120
PMCID:
PMC10104498
AbstractArticlePDF–7.4M
4.
Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly
Chiara Klöckner, J Pedro Fernández-Murray, Mahtab Tavasoli, Heinrich Sticht, Gisela Stoltenburg-Didinger, Leila Motlagh Scholle, Somayeh Bakhtiari, Michael C Kruer, Hossein Darvish, Saghar Ghasemi Firouzabadi, Alex Pagnozzi, Anju Shukla, Katta Mohan Girisha, Dhanya Lakshmi Narayanan, Parneet Kaur, Reza Maroofian, Maha S Zaki, Mahmoud M Noureldeen, Andreas Merkenschlager, Janina Gburek-Augustat, Elisa Cali, Selina Banu, Kamrun Nahar, Stephanie Efthymiou, Henry Houlden, Rami Abou Jamra, Jason Williams, Christopher R McMaster, Konrad Platzer
Brain. 2022 Jun; 145(6): 1916–1923. Published online 2022 Feb 24. doi: 10.1093/brain/awac074
PMCID:
PMC9630884
AbstractArticlePDF–1.6M
5.
DNA Methylation of Human Choline Kinase Alpha Promoter-Associated CpG Islands in MCF-7 Cells
Siti Aisyah Faten Mohamed Sa’dom, Sweta Raikundalia, Shaharum Shamsuddin, Wei Cun See Too, Ling Ling Few
Genes (Basel) 2021 Jun; 12(6): 853. Published online 2021 Jun 1. doi: 10.3390/genes12060853
PMCID:
PMC8229565
AbstractArticlePDF–2.1M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
8.
Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression
Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Shao Li, Jing-Feng Liu, Frank J. Gonzalez, Meng-Chao Wu, Hong-Yang Wang, Lei Chen
Gastroenterology. Author manuscript; available in PMC 2019 Jul 28.
Published in final edited form as: Gastroenterology. 2017 Apr; 152(5): 1187–1202. Published online 2017 Jan 5. doi: 10.1053/j.gastro.2016.12.033
PMCID:
PMC6661112
AbstractArticlePDF–3.3M
9.
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells
Pablo Domizi, Florencia Malizia, Lorena Chazarreta-Cifre, Lautaro Diacovich, Claudia Banchio
PLoS One. 2019; 14(1): e0210207. Published online 2019 Jan 10. doi: 10.1371/journal.pone.0210207
PMCID:
PMC6328129
AbstractArticlePDF–1.8M
10.
Increased Choline Kinase Activity and Elevated Phosphocholine Levels in Human Colon Cancer
Katsunao Nakagami, Tsutomu Uchida, Susumu Ohwada, Yukio Koibuchi, Yasuo Suda, Takeshi Sekine, Yasuo Morishita
Jpn J Cancer Res. 1999 Apr; 90(4): 419–424. doi: 10.1111/j.1349-7006.1999.tb00764.x
PMCID:
PMC5926083
SummaryPDF–105K
11.
Hypoxia Regulates Choline Kinase Expression through Hypoxia-Inducible Factor-1α Signaling in a Human Prostate Cancer Model
Kristine Glunde, Tariq Shah, Paul T. Winnard, Jr., Venu Raman, Tomoyo Takagi, Farhad Vesuna, Dmitri Artemov, Zaver M. Bhujwalla
Cancer Res. Author manuscript; available in PMC 2017 Sep 20.
Published in final edited form as: Cancer Res. 2008 Jan 1; 68(1): 172–180. doi: 10.1158/0008-5472.CAN-07-2678
PMCID:
PMC5606139
AbstractArticlePDF–757K
12.
Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication
Mun-Teng Wong, Steve S. Chen
J Virol. 2017 Aug 15; 91(16): e00355-17. Prepublished online 2017 May 31. Published online 2017 Jul 27. doi: 10.1128/JVI.00355-17
PMCID:
PMC5533930
AbstractArticlePDF–11M
13.
Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma
Liang Hu, Ruo-Yu Wang, Jian Cai, Dan Feng, Guang-Zhen Yang, Qing-Guo Xu, Yan-Xia Zhai, Yu Zhang, Wei-Ping Zhou, Qing-Ping Cai
Oncotarget. 2016 Oct 11; 7(41): 66660–66678. Published online 2016 Aug 20. doi: 10.18632/oncotarget.11433
PMCID:
PMC5341828
AbstractArticlePDF–13M
14.
Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation
Mun-Teng Wong, Steve S. Chen
J Virol. 2016 Oct 15; 90(20): 9075–9095. Prepublished online 2016 Aug 3. Published online 2016 Sep 29. doi: 10.1128/JVI.00960-16
PMCID:
PMC5044849
AbstractArticlePDF–6.0M
15.
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target
Mohammad Asim, Charles E. Massie, Folake Orafidiya, Nelma Pértega-Gomes, Anne Y. Warren, Mohsen Esmaeili, Luke A. Selth, Heather I. Zecchini, Katarina Luko, Arham Qureshi, Ajoeb Baridi, Suraj Menon, Basetti Madhu, Carlos Escriu, Scott Lyons, Sarah L. Vowler, Vincent R. Zecchini, Greg Shaw, Wiebke Hessenkemper, Roslin Russell, Hisham Mohammed, Niki Stefanos, Andy G. Lynch, Elena Grigorenko, Clive D’Santos, Chris Taylor, Alastair Lamb, Rouchelle Sriranjan, Jiali Yang, Rory Stark, Scott M. Dehm, Paul S. Rennie, Jason S. Carroll, John R. Griffiths, Simon Tavaré, Ian G. Mills, Iain J. McEwan, Aria Baniahmad, Wayne D. Tilley, David E. Neal
J Natl Cancer Inst. 2016 May; 108(5): djv371. Published online 2015 Dec 11. doi: 10.1093/jnci/djv371
PMCID:
PMC4849803
AbstractArticlePDF–14M
16.
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells
Hoe Suk Kim, Lianji Tian, Minji Jung, Sul Ki Choi, Yujin Sun, Hyeonjin Kim, Woo Kyung Moon
PLoS One. 2015; 10(10): e0141110. Published online 2015 Oct 23. doi: 10.1371/journal.pone.0141110
PMCID:
PMC4619766
AbstractArticlePDF–1.8M
17.
Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma
Anna Granata, Roberta Nicoletti, Paola Perego, Egidio Iorio, Balaji Krishnamachary, Fabio Benigni, Alessandro Ricci, Franca Podo, Zaver M. Bhujwalla, Silvana Canevari, Marina Bagnoli, Delia Mezzanzanica
Oncotarget. 2015 May 10; 6(13): 11216–11230. Published online 2015 Mar 14. doi: 10.18632/oncotarget.3589
PMCID:
PMC4484451
AbstractArticlePDF–1.8M
18.
Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting
J Xiong, J Bian, L Wang, J-Y Zhou, Y Wang, Y Zhao, L-L Wu, J-J Hu, B Li, S-J Chen, C Yan, W-L Zhao
Blood Cancer J. 2015 Mar; 5(3): 287. Published online 2015 Mar 13. doi: 10.1038/bcj.2015.10
PMCID:
PMC4382653
AbstractArticlePDF–4.7M
19.
Direct Inhibition of Choline Kinase by a Near-Infrared Fluorescent Carbocyanine
Sean P. Arlauckas, Anatoliy V. Popov, Edward J. Delikatny
Mol Cancer Ther. Author manuscript; available in PMC 2015 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2014 Sep; 13(9): 2149–2158. Published online 2014 Jul 15. doi: 10.1158/1535-7163.MCT-14-0085
PMCID:
PMC4209917
AbstractArticlePDF–1.1M
20.
Phospholipase D1 and choline kinase-α are interactive targets in breast cancer
Mayur Gadiya, Noriko Mori, Maria D Cao, Yelena Mironchik, Samata Kakkad, Ingrid S Gribbestad, Kristine Glunde, Balaji Krishnamachary, Zaver M Bhujwalla
Cancer Biol Ther. 2014 May 1; 15(5): 593–601. Published online 2014 Feb 20. doi: 10.4161/cbt.28165
PMCID:
PMC4026082
AbstractArticlePDF–1.6M

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