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Select item 105624931.

The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer

Kirsty Hodgson, Margarita Orozco-Moreno, Emma Scott, Rebecca Garnham, Karen Livermore, Huw Thomas, Yuhan Zhou, Jiepei He, Abel Bermudez, Fernando Jose Garcia Marques, Kayla Bastian, Gerald Hysenaj, Emily Archer Goode, Rakesh Heer, Sharon Pitteri, Ning Wang, David J. Elliott, Jennifer Munkley

Sci Rep. 2023; 13: 17031. Published online 2023 Oct 9. doi: 10.1038/s41598-023-43019-8

PMCID:: PMC10562493

Abstract Article PDF–5.4M

Select item 92316232.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 84212673.

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

Lawrence G. Welch, Sew-Yeu Peak-Chew, Farida Begum, Tim J. Stevens, Sean Munro

J Cell Biol. 2021 Oct 4; 220(10): e202106115. Published online 2021 Sep 2. doi: 10.1083/jcb.202106115

PMCID:: PMC8421267

Abstract Article PDF–5.4M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73220675.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 62993686.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 58621407.

Increased Expression of GCNT1 is Associated With Altered O-glycosylation of PSA, PAP, and MUC1 in Human Prostate Cancers

Zuxiong Chen, Zulfiqar G. Gulzar, Catherine A. St. Hill, Bruce Walcheck, James D. Brooks

Prostate. Author manuscript; available in PMC 2018 Mar 21.

Published in final edited form as: Prostate. 2014 Jul; 74(10): 1059–1067. Published online 2014 May 22. doi: 10.1002/pros.22826

PMCID:: PMC5862140

Abstract Article PDF–649K

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 46172119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 457712810.

Detection of Core2 β-1,6-N-Acetylglucosaminyltransferase in Post-Digital Rectal Examination Urine Is a Reliable Indicator for Extracapsular Extension of Prostate Cancer

Yuta Kojima, Tohru Yoneyama, Shingo Hatakeyama, Jotaro Mikami, Tendo Sato, Kazuyuki Mori, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama, Minoru Fukuda, Yuki Tobisawa

PLoS One. 2015; 10(9): e0138520. Published online 2015 Sep 21. doi: 10.1371/journal.pone.0138520

PMCID:: PMC4577128

Abstract Article PDF–1.1M

Select item 427264111.

Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-induced Apoptosis by Modifying Mucin O-glycan Synthesis

Armen Petrosyan, Melissa S. Holzapfel, David E. Muirhead, Pi-Wan Cheng

Mol Cancer Res. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Mol Cancer Res. 2014 Dec; 12(12): 1704–1716. Published online 2014 Aug 1. doi: 10.1158/1541-7786.MCR-14-0291-T

PMCID:: PMC4272641

Abstract Article PDF–3.8M

Select item 393362012.

Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases

Armen Petrosyan, Pi-Wan Cheng

Cell Stress Chaperones. 2014 Mar; 19(2): 241–254. Published online 2013 Aug 30. doi: 10.1007/s12192-013-0450-y

PMCID:: PMC3933620

Abstract Article PDF–939K

Select item 357303413.

Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity

TEPPEI OKAMOTO, MIHOKO SUTOH YONEYAMA, SHINGO HATAKEYAMA, KAZUYUKI MORI, HAYATO YAMAMOTO, TAKUYA KOIE, HISAO SAITOH, KANEMITSU YAMAYA, TOMIHISA FUNYU, MINORU FUKUDA, CHIKARA OHYAMA, SHIGERU TSUBOI

Mol Med Rep. 2013 Feb; 7(2): 359–364. Published online 2012 Nov 19. doi: 10.3892/mmr.2012.1189

PMCID:: PMC3573034

Abstract Article PDF–623K

Select item 350102714.

Golgi Phosphoprotein 3 Determines Cell Binding Properties under Dynamic Flow by Controlling Golgi Localization of Core 2 N-Acetylglucosaminyltransferase 1

Mohamed F. Ali, Vishwanath B. Chachadi, Armen Petrosyan, Pi-Wan Cheng

J Biol Chem. 2012 Nov 16; 287(47): 39564–39577. Published online 2012 Oct 1. doi: 10.1074/jbc.M112.346528

PMCID:: PMC3501027

Abstract Article PDF–2.9M

Select item 320295915.

Genome-Wide Association Scan for Survival on Dialysis in African-Americans with Type 2 Diabetes

Mariana Murea, Lingyi Lu, Lijun Ma, Pamela J. Hicks, Jasmin Divers, Caitrin W. McDonough, Carl D. Langefeld, Donald W. Bowden, Barry I. Freedman

Am J Nephrol. 2011 Jun; 33(6): 502–509. Published online 2011 May 5. doi: 10.1159/000327985

PMCID:: PMC3202959

Abstract Article PDF–425K

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316018917.

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

Shigeru Tsuboi, Mihoko Sutoh, Shingo Hatakeyama, Nobuyoshi Hiraoka, Tomonori Habuchi, Yohei Horikawa, Yasuhiro Hashimoto, Takahiro Yoneyama, Kazuyuki Mori, Takuya Koie, Toshiya Nakamura, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Minoru Fukuda, Chikara Ohyama

EMBO J. 2011 Aug 3; 30(15): 3173–3185. Published online 2011 Jun 28. doi: 10.1038/emboj.2011.215

PMCID:: PMC3160189

Abstract Article PDF–908K

Select item 298837318.

Core2 O-Glycan Structure Is Essential for the Cell Surface Expression of Sucrase Isomaltase and Dipeptidyl Peptidase-IV during Intestinal Cell Differentiation

Seung Ho Lee, Shin-Yi Yu, Jun Nakayama, Kai-Hooi Khoo, Erica L. Stone, Michiko N. Fukuda, Jamey D. Marth, Minoru Fukuda

J Biol Chem. 2010 Nov 26; 285(48): 37683–37692. Published online 2010 Sep 14. doi: 10.1074/jbc.M110.162735

PMCID:: PMC2988373

Abstract Article PDF–2.9M

Select item 289792919.

Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor

Shingo Hatakeyama, Atsushi Kyan, Hayato Yamamoto, Akiko Okamoto, Naoki Sugiyama, Yuichiro Suzuki, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shigeyuki Yamada, Hideo Saito, Yoichi Arai, Minoru Fukuda, Chikara Ohyama

Int J Cancer. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Int J Cancer. 2010 Sep 1; 127(5): 1052–1059. doi: 10.1002/ijc.25117

PMCID:: PMC2897929

Abstract Article PDF–2.8M

Select item 266287320.

The high affinity selectin glycan ligand C2-O-sLe^xand mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao, Bruce Walcheck

BMC Cancer. 2009; 9: 79. Published online 2009 Mar 6. doi: 10.1186/1471-2407-9-79

PMCID:: PMC2662873

Abstract Article PDF–2.3M

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