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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73975692.

THEMIS-SHP1 Recruitment by 4–1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro Dotti

Cancer Cell. Author manuscript; available in PMC 2021 Feb 10.

Published in final edited form as: Cancer Cell. 2020 Feb 10; 37(2): 216–225.e6. Published online 2020 Jan 30. doi: 10.1016/j.ccell.2019.12.014

PMCID:: PMC7397569

Abstract Article PDF–2.6M

Select item 58070803.

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1

Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty, Renaud Lesourne, L. Aravind, Paul E. Love

Nat Immunol. Author manuscript; available in PMC 2018 Feb 9.

Published in final edited form as: Nat Immunol. 2017 Apr; 18(4): 433–441. Published online 2017 Feb 27. doi: 10.1038/ni.3692

PMCID:: PMC5807080

Abstract Article PDF–1.1M

Select item 55316114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 52348495.

HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors

Haruka Kinosada, Jun-ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka

PLoS Pathog. 2017 Jan; 13(1): e1006120. Published online 2017 Jan 3. doi: 10.1371/journal.ppat.1006120

Correction in:: PLoS Pathog. 2017 Feb; 13(2): e1006228.

PMCID:: PMC5234849

Abstract Article PDF–5.6M

Select item 49546976.

Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis

Jessica L. Davies, Sara Thompson, Harpreet Kaur-Sandhu, Stephen Sawcer, Alasdair Coles, Maria Ban, Joanne Jones

PLoS One. 2016; 11(7): e0158327. Published online 2016 Jul 20. doi: 10.1371/journal.pone.0158327

PMCID:: PMC4954697

Abstract Article PDF–907K

Select item 43391247.

A THEMIS:SHP1 complex promotes T-cell survival

Wolfgang Paster, Annika M Bruger, Kristin Katsch, Claude Grégoire, Romain Roncagalli, Guo Fu, Nicholas RJ Gascoigne, Konstantina Nika, Andre Cohnen, Stephan M Feller, Philip C Simister, Kelly C Molder, Shaun-Paul Cordoba, Omer Dushek, Bernard Malissen, Oreste Acuto

EMBO J. 2015 Feb 3; 34(3): 393–409. Published online 2014 Dec 22. doi: 10.15252/embj.201387725

PMCID:: PMC4339124

Abstract Article PDF–1.3M

Select item 41705858.

Genome-Wide Analysis of Polymorphisms Associated with Cytokine Responses in Smallpox Vaccine Recipients

Richard B. Kennedy, Inna G. Ovsyannikova, V. Shane Pankratz, Iana H. Haralambieva, Robert A. Vierkant, Gregory A. Poland

Hum Genet. Author manuscript; available in PMC 2014 Sep 22.

Published in final edited form as: Hum Genet. 2012 Sep; 131(9): 1403–1421. Published online 2012 May 19. doi: 10.1007/s00439-012-1174-2

PMCID:: PMC4170585

Abstract Article PDF–594K

Select item 39770019.

Themis sets the signal threshold for positive and negative selection in T-cell development

Guo Fu, Javier Casas, Stephanie Rigaud, Vasily Rybakin, Florence Lambolez, Joanna Brzostek, John A.H. Hoerter, Wolfgang Paster, Oreste Acuto, Hilde Cheroutre, Karsten Sauer, Nicholas R.J. Gascoigne

Nature. Author manuscript; available in PMC 2014 Jun 19.

Published in final edited form as: Nature. 2013 Dec 19; 504(7480): 441–445. Published online 2013 Nov 13. doi: 10.1038/nature12718

PMCID:: PMC3977001

Article PDF–5.4M

Select item 392526410.

THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge

Constanza Bondar, Leticia Plaza-Izurieta, Nora Fernandez-Jimenez, Iñaki Irastorza, Sebo Withoff, CEGEC, Cisca Wijmenga, Fernando Chirdo, Jose Ramon Bilbao

Eur J Hum Genet. 2014 Mar; 22(3): 358–362. Published online 2013 Jul 3. doi: 10.1038/ejhg.2013.136

PMCID:: PMC3925264

Abstract Article PDF–579K

Select item 374394611.

Generalization of Variants Identified by Genome-wide Association Studies for Electrocardiographic Traits in African Americans

Janina M. Jeff, Marylyn D. Ritchie, Joshua C. Denny, Abel N. Kho, Andrea H. Ramirez, David Crosslin, Loren Armstrong, Melissa A. Basford, Wendy A. Wolf, Jennifer A. Pacheco, Rex L. Chisholm, Dan M. Roden, M. Geoffrey Hayes, Dana C. Crawford

Ann Hum Genet. Author manuscript; available in PMC 2014 Jul 30.

Published in final edited form as: Ann Hum Genet. 2013 Jul; 77(4): 321–332. Published online 2013 Mar 28. doi: 10.1111/ahg.12023

PMCID:: PMC3743946

Abstract Article PDF–375K

Select item 367302212.

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Christopher E. Barbieri, Sylvan C. Baca, Michael S. Lawrence, Francesca Demichelis, Mirjam Blattner, Jean-Philippe Theurillat, Thomas A. White, Petar Stojanov, Eliezer Van Allen, Nicolas Stransky, Elizabeth Nickerson, Sung-Suk Chae, Gunther Boysen, Daniel Auclair, Robert Onofrio, Kyung Park, Naoki Kitabayashi, Theresa Y. MacDonald, Karen Sheikh, Terry Vuong, Candace Guiducci, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Gordon Saksena, Douglas Voet, Wasay M. Hussain, Alex H. Ramos, Wendy Winckler, Michelle C. Redman, Kristin Ardlie, Ashutosh K. Tewari, Juan Miguel Mosquera, Niels Rupp, Peter J. Wild, Holger Moch, Colm Morrissey, Peter S. Nelson, Philip W. Kantoff, Stacey B. Gabriel, Todd R. Golub, Matthew Meyerson, Eric S. Lander, Gad Getz, Mark A. Rubin, Levi A. Garraway

Nat Genet. Author manuscript; available in PMC 2013 Jun 5.

Published in final edited form as: Nat Genet. 2012 May 20; 44(6): 685–689. Published online 2012 May 20. doi: 10.1038/ng.2279

PMCID:: PMC3673022

Abstract Article PDF–2.3M

Select item 360740313.

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

Wolfgang Paster, Claudia Brockmeyer, Guo Fu, Philip C. Simister, Ben de Wet, Ana Martinez-Riaño, John A. H. Hoerter, Stephan M. Feller, Christoph Wülfing, Nicholas R. J. Gascoigne, Oreste Acuto

J Immunol. 2013 Apr 1; 190(7): 3749–3756. Published online 2013 Mar 4. doi: 10.4049/jimmunol.1203389

PMCID:: PMC3607403

Abstract Article PDF–1.9M

Select item 340135714.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

Renaud Lesourne, Ekaterina Zvezdova, Ki-Duk Song, Dalal El-Khoury, Shoji Uehara, Valarie A. Barr, Lawrence E. Samelson, Paul E. Love

J Immunol. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: J Immunol. 2012 Aug 1; 189(3): 1154–1161. Published online 2012 Jun 25. doi: 10.4049/jimmunol.1200123

PMCID:: PMC3401357

Abstract Article PDF–1.3M

Select item 318253115.

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium (IMSGC), Wellcome Trust Case Control Consortium 2 (WTCCC2), Stephen Sawcer, Garrett Hellenthal, Matti Pirinen, Chris C.A. Spencer, Nikolaos A. Patsopoulos, Loukas Moutsianas, Alexander Dilthey, Zhan Su, Colin Freeman, Sarah E. Hunt, Sarah Edkins, Emma Gray, David R. Booth, Simon C. Potter, An Goris, Gavin Band, Annette Bang Oturai, Amy Strange, Janna Saarela, Céline Bellenguez, Bertrand Fontaine, Matthew Gillman, Bernhard Hemmer, Rhian Gwilliam, Frauke Zipp, Alagurevathi Jayakumar, Roland Martin, Stephen Leslie, Stanley Hawkins, Eleni Giannoulatou, Sandra D’alfonso, Hannah Blackburn, Filippo Martinelli Boneschi, Jennifer Liddle, Hanne F. Harbo, Marc L. Perez, Anne Spurkland, Matthew J Waller, Marcin P. Mycko, Michelle Ricketts, Manuel Comabella, Naomi Hammond, Ingrid Kockum, Owen T. McCann, Maria Ban, Pamela Whittaker, Anu Kemppinen, Paul Weston, Clive Hawkins, Sara Widaa, John Zajicek, Serge Dronov, Neil Robertson, Suzannah J. Bumpstead, Lisa F. Barcellos, Rathi Ravindrarajah, Roby Abraham, Lars Alfredsson, Kristin Ardlie, Cristin Aubin, Amie Baker, Katharine Baker, Sergio E. Baranzini, Laura Bergamaschi, Roberto Bergamaschi, Allan Bernstein, Achim Berthele, Mike Boggild, Jonathan P. Bradfield, David Brassat, Simon A. Broadley, Dorothea Buck, Helmut Butzkueven, Ruggero Capra, William M. Carroll, Paola Cavalla, Elisabeth G. Celius, Sabine Cepok, Rosetta Chiavacci, Françoise Clerget-Darpoux, Katleen Clysters, Giancarlo Comi, Mark Cossburn, Isabelle Cournu-Rebeix, Mathew B. Cox, Wendy Cozen, Bruce A.C. Cree, Anne H. Cross, Daniele Cusi, Mark J. Daly, Emma Davis, Paul I.W. de Bakker, Marc Debouverie, Marie Beatrice D’hooghe, Katherine Dixon, Rita Dobosi, Bénédicte Dubois, David Ellinghaus, Irina Elovaara, Federica Esposito, Claire Fontenille, Simon Foote, Andre Franke, Daniela Galimberti, Angelo Ghezzi, Joseph Glessner, Refujia Gomez, Olivier Gout, Colin Graham, Struan F.A. Grant, Franca Rosa Guerini, Hakon Hakonarson, Per Hall, Anders Hamsten, Hans-Peter Hartung, Rob N. Heard, Simon Heath, Jeremy Hobart, Muna Hoshi, Carmen Infante-Duarte, Gillian Ingram, Wendy Ingram, Talat Islam, Maja Jagodic, Michael Kabesch, Allan G. Kermode, Trevor J. Kilpatrick, Cecilia Kim, Norman Klopp, Keijo Koivisto, Malin Larsson, Mark Lathrop, Jeannette S. Lechner-Scott, Maurizio A. Leone, Virpi Leppä, Ulrika Liljedahl, Izaura Lima Bomfim, Robin R. Lincoln, Jenny Link, Jianjun Liu, Åslaug R. Lorentzen, Sara Lupoli, Fabio Macciardi, Thomas Mack, Mark Marriott, Vittorio Martinelli, Deborah Mason, Jacob L. McCauley, Frank Mentch, Inger-Lise Mero, Tania Mihalova, Xavier Montalban, John Mottershead, Kjell-Morten Myhr, Paola Naldi, William Ollier, Alison Page, Aarno Palotie, Jean Pelletier, Laura Piccio, Trevor Pickersgill, Fredrik Piehl, Susan Pobywajlo, Hong L. Quach, Patricia P. Ramsay, Mauri Reunanen, Richard Reynolds, John D. Rioux, Mariaemma Rodegher, Sabine Roesner, Justin P. Rubio, Ina-Maria Rückert, Marco Salvetti, Erika Salvi, Adam Santaniello, Catherine A. Schaefer, Stefan Schreiber, Christian Schulze, Rodney J. Scott, Finn Sellebjerg, Krzysztof W. Selmaj, David Sexton, Ling Shen, Brigid Simms-Acuna, Sheila Skidmore, Patrick M.A. Sleiman, Cathrine Smestad, Per Soelberg Sørensen, Helle Bach Søndergaard, Jim Stankovich, Richard C. Strange, Anna-Maija Sulonen, Emilie Sundqvist, Ann-Christine Syvänen, Francesca Taddeo, Bruce Taylor, Jenefer M. Blackwell, Pentti Tienari, Elvira Bramon, Ayman Tourbah, Matthew A. Brown, Ewa Tronczynska, Juan P. Casas, Niall Tubridy, Aiden Corvin, Jane Vickery, Janusz Jankowski, Pablo Villoslada, Hugh S. Markus, Kai Wang, Christopher G. Mathew, James Wason, Colin N.A. Palmer, H-Erich Wichmann, Robert Plomin, Ernest Willoughby, Anna Rautanen, Juliane Winkelmann, Michael Wittig, Richard C. Trembath, Jacqueline Yaouanq, Ananth C. Viswanathan, Haitao Zhang, Nicholas W. Wood, Rebecca Zuvich, Panos Deloukas, Cordelia Langford, Audrey Duncanson, Jorge R. Oksenberg, Margaret A. Pericak-Vance, Jonathan L. Haines, Tomas Olsson, Jan Hillert, Adrian J. Ivinson, Philip L. De Jager, Leena Peltonen, Graeme J. Stewart, David A. Hafler, Stephen L. Hauser, Gil McVean, Peter Donnelly, Alastair Compston

Nature. Author manuscript; available in PMC 2012 Feb 11.

Published in final edited form as: Nature. 2011 Aug 10; 476(7359): 214–219. Published online 2011 Aug 10. doi: 10.1038/nature10251

PMCID:: PMC3182531

Abstract Article PDF–2.0M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 304500817.

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

Claudia Brockmeyer, Wolfgang Paster, David Pepper, Choon P. Tan, David C. Trudgian, Simon McGowan, Guo Fu, Nicholas R. J. Gascoigne, Oreste Acuto, Mogjiborahman Salek

J Biol Chem. 2011 Mar 4; 286(9): 7535–7547. Published online 2010 Dec 28. doi: 10.1074/jbc.M110.201236

PMCID:: PMC3045008

Abstract Article PDF–2.6M

Select item 294516818.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 292287019.

Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. Radiologic Technologists

Parveen Bhatti, Michele M. Doody, Preetha Rajaraman, Bruce H. Alexander, Meredith Yeager, Amy Hutchinson, Laurie Burdette, Gilles Thomas, David J. Hunter, Steven L. Simon, Robert M. Weinstock, Marvin Rosenstein, Marilyn Stovall, Dale L. Preston, Martha S. Linet, Robert N. Hoover, Stephen J. Chanock, Alice J. Sigurdson

Radiat Res. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Radiat Res. 2010 Feb; 173(2): 214–224. doi: 10.1667/RR1985.1

PMCID:: PMC2922870

Abstract Article PDF–345K

Select item 290898920.

Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection

Andy L. Johnson, L. Aravind, Natalia Shulzhenko, Andriy Morgun, See-Young Choi, Tanya L. Crockford, Teresa Lambe, Heather Domaschenz, Edyta Kucharska, Lixin Zheng, Carola C. Vinuesa, Michael J. Lenardo, Christopher C. Goodnow, Richard J. Cornall, Ronald H. Schwartz

Nat Immunol. Author manuscript; available in PMC 2010 Jul 23.

Published in final edited form as: Nat Immunol. 2009 Aug; 10(8): 831–839. Published online 2009 Jul 13. doi: 10.1038/ni.1769

Correction in:: volume 11 on page 97

PMCID:: PMC2908989

Abstract Article PDF–1.4M

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