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Items: 1 to 20 of 71

1.
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
Lucy Barnsby-Greer, Peter D. Mabbitt, Marc-Andre Dery, Daniel R. Squair, Nicola T. Wood, Frederic Lamoliatte, Sven M. Lange, Satpal Virdee
Nat Struct Mol Biol. 2024; 31(2): 351–363. Published online 2024 Jan 5. doi: 10.1038/s41594-023-01192-4
PMCID:
PMC10873205
AbstractArticlePDF–11M
2.
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism
Mengyuan Lyu, Jian Zhou, Yanbing Zhou, Weelic Chong, Wei Xu, Hongli Lai, Lu Niu, Yang Hai, Xiaojun Yao, Sheng Gong, Qinglan Wang, Yi Chen, Yili Wang, Liyu Chen, Zengwanggema, Jiongjiong Zeng, Chengdi Wang, Binwu Ying
Signal Transduct Target Ther. 2023; 8: 82. Published online 2023 Feb 24. doi: 10.1038/s41392-023-01346-2
PMCID:
PMC9958017
AbstractArticlePDF–3.6M
3.
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
Ryota Hayashida, Reika Kikuchi, Kenichiro Imai, Waka Kojima, Tatsuya Yamada, Miho Iijima, Hiromi Sesaki, Keiji Tanaka, Noriyuki Matsuda, Koji Yamano
J Biol Chem. 2023 Feb; 299(2): 102822. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102822
PMCID:
PMC9860496
AbstractArticlePDF–6.6M
4.
DDX24 promotes metastasis by regulating RPL5 in non‐small cell lung cancer
Xinyan Hu, Fangfang Li, Yulan Zhou, Hairun Gan, Tiancheng Wang, Luting Li, Haoyu Long, Bing Li, Pengfei Pang
Cancer Med. 2022 Dec; 11(23): 4513–4525. Published online 2022 Jul 21. doi: 10.1002/cam4.4835
PMCID:
PMC9741967
AbstractArticlePDF–25M
5.
Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability
Prakash K. Shukla, Dhiraj Sinha, Andrew M. Leng, Jesse E. Bissell, Shravya Thatipamula, Rajarshi Ganguly, Kaitlin S. Radmall, Jack J. Skalicky, Dennis C. Shrieve, Mahesh B. Chandrasekharan
J Biol Chem. 2022 Nov; 298(11): 102524. Published online 2022 Sep 23. doi: 10.1016/j.jbc.2022.102524
PMCID:
PMC9630792
AbstractArticlePDF–4.0M
6.
UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization
Xi Zeng, Wen Zheng, Yuting Sheng, Hongwei Ma
Bioengineered. 2022; 13(4): 8000–8012. Published online 2022 Mar 22. doi: 10.1080/21655979.2022.2048991
PMCID:
PMC9161992
AbstractArticlePDF–3.7M
7.
A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade
Gabriel Fenteany, Gaurav Sharma, Paras Gaur, Attila Borics, Edit Wéber, Ernő Kiss, Lajos Haracska
iScience. 2022 Apr 15; 25(4): 104053. Published online 2022 Mar 10. doi: 10.1016/j.isci.2022.104053
PMCID:
PMC8958325
AbstractArticlePDF–3.2M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling
Ashapurna Sarma, Ambikai Gajan, Seongho Kim, Katherine Gurdziel, Guangzhao Mao, Pratima Nangia-Makker, Malathy P.V. Shekhar
Am J Pathol. 2021 Feb; 191(2): 368–384. doi: 10.1016/j.ajpath.2020.10.015
PMCID:
PMC7888193
AbstractArticlePDF–3.8M
10.
Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling
Jang-Hyun Oh, Ju-Yeon Hyun, Shun-Jia Chen, Alexander Varshavsky
Proc Natl Acad Sci U S A. 2020 May 19; 117(20): 10778–10788. Published online 2020 May 4. doi: 10.1073/pnas.2003043117
PMCID:
PMC7245096
AbstractArticlePDF–1.7M
11.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
12.
Allosteric mechanism for site-specific ubiquitination of FANCD2
Viduth K. Chaugule, Connor Arkinson, Martin L. Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden
Nat Chem Biol. Author manuscript; available in PMC 2020 Jun 23.
Published in final edited form as: Nat Chem Biol. 2020 Mar; 16(3): 291–301. Published online 2019 Dec 23. doi: 10.1038/s41589-019-0426-z
PMCID:
PMC7035956
AbstractArticlePDF–2.5M
13.
Alternative Splicing of RAD6B and Not RAD6A Is Selectively Increased in Melanoma: Identification and Functional Characterization
Ambikai Gajan, Carly E. Martin, Seongho Kim, Milap Joshi, Sharon K. Michelhaugh, Ido Sloma, Sandeep Mittal, Steven Firestine, Malathy P. V. Shekhar
Cells. 2019 Nov; 8(11): 1375. Published online 2019 Nov 1. doi: 10.3390/cells8111375
PMCID:
PMC6912459
AbstractArticlePDF–1.9M
14.
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence
Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. Shekhar
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1; 1866(1): 165561. Published online 2019 Oct 19. doi: 10.1016/j.bbadis.2019.165561
PMCID:
PMC6896319
AbstractArticlePDF–3.3M
15.
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge
Mol Cell. Author manuscript; available in PMC 2019 Dec 4.
Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008
PMCID:
PMC6892393
AbstractArticlePDF–1.7M
16.
Crystal structure of a human ubiquitin E1–ubiquitin complex reveals conserved functional elements essential for activity
Zongyang Lv, Katelyn M. Williams, Lingmin Yuan, James H. Atkison, Shaun K. Olsen
J Biol Chem. 2018 Nov 23; 293(47): 18337–18352. Published online 2018 Oct 2. doi: 10.1074/jbc.RA118.003975
PMCID:
PMC6254350
AbstractArticlePDF–6.9M
17.
DNA repair protein Rad18 restricts LINE-1 mobility
Yasuo Ariumi, Koudai Kawano, Mariko Yasuda-Inoue, Misao Kuroki, Hiroyuki Fukuda, Rokeya Siddiqui, Priscilla Turelli, Satoshi Tateishi
Sci Rep. 2018; 8: 15894. Published online 2018 Oct 26. doi: 10.1038/s41598-018-34288-9
PMCID:
PMC6203705
AbstractArticlePDF–3.6M
18.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
19.
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance
Ranganatha R. Somasagara, Sebastian M. Spencer, Kaushlendra Tripathi, David W. Clark, Chinnadurai Mani, Luciana Madeira da Silva, Jennifer Scalici, Hend Kothayer, Andrew D. Westwell, Rodney P. Rocconi, Komaraiah Palle
Oncogene. Author manuscript; available in PMC 2018 Feb 14.
Published in final edited form as: Oncogene. 2017 Nov 30; 36(48): 6680–6690. Published online 2017 Aug 14. doi: 10.1038/onc.2017.279
PMCID:
PMC5709226
AbstractArticlePDF–1.3M
20.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M

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