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Select item 108664341.

PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance

Shiue-Wei Lai, Yi-Chiao Cheng, Kee-Thai Kiu, Min-Hsuan Yen, Ying-Wei Chen, Vijesh Kumar Yadav, Chi-Tai Yeh, Kuang-Tai Kuo, Tung-Cheng Chang

Aging (Albany NY) 2024 Jan 31; 16(2): 1620–1639. Published online 2024 Jan 18. doi: 10.18632/aging.205447

PMCID:: PMC10866434

Abstract Article PDF–2.2M

Select item 105242062.

Defects In Vein Valve PROX1/FOXC2 Antithrombotic Pathway in Endothelial Cells Drive the Hypercoagulable State Induced by Trauma and Critical Illness

Mark H. Hoofnagle, Annie Hess, Margaret Nalugo, Sarbani Ghosh, Shin-Wen Hughes, Anja Fuchs, John Welsh, Mark Kahn, Grant V Bochicchio, Gwendalyn J Randolph, Jennifer M. Leonard, Isaiah R Turnbull

J Trauma Acute Care Surg. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Trauma Acute Care Surg. 2023 Aug 1; 95(2): 197–204. Published online 2023 Apr 19. doi: 10.1097/TA.0000000000003945

PMCID:: PMC10524206

Abstract Article PDF–952K

Select item 103779223.

Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression

Artemis Michail, Dimitrios Gkikas, Dimitris Stellas, Valeria Kaltezioti, Panagiotis K. Politis

Cells. 2023 Jul; 12(14): 1869. Published online 2023 Jul 17. doi: 10.3390/cells12141869

PMCID:: PMC10377922

Abstract Article PDF–5.3M

Select item 101951364.

PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer: PROX1 inhibits ferroptosis in CRC

Ruoxin Zhang, Dakui Luo, Zezhi Shan, Yufei Yang, Yi Qin, Qingguo Li, Xinxiang Li

Acta Biochim Biophys Sin (Shanghai) 2023 Apr; 55(4): 691–694. Published online 2023 Feb 23. doi: 10.3724/abbs.2023027

PMCID:: PMC10195136

Article PDF–824K

Select item 99367485.

Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

Wenjian Yao, Xiangbo Jia, Li Zhu, Lei Xu, Quan Zhang, Tian Xia, Li Wei

Cell Mol Biol Lett. 2023; 28: 13. Published online 2023 Feb 17. doi: 10.1186/s11658-022-00410-z

PMCID:: PMC9936748

Abstract Article PDF–5.9M

Select item 97008656.

AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis

Yanan Wang, Mengjun Luo, Fan Wang, Yu Tong, Linfeng Li, Yu Shu, Ke Qiao, Lei Zhang, Guoquan Yan, Jing Liu, Hongbin Ji, Youhua Xie, Yonglong Zhang, Wei-Qiang Gao, Yanfeng Liu

Nat Commun. 2022; 13: 7215. Published online 2022 Nov 24. doi: 10.1038/s41467-022-34747-y

PMCID:: PMC9700865

Abstract Article PDF–14M

Select item 89858437.

Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production

Silvia Gramolelli, Endrit Elbasani, Krista Tuohinto, Veijo Nurminen, Thomas Günther, Riikka E. Kallinen, Seppo P. Kaijalainen, Raquel Diaz, Adam Grundhoff, Caj Haglund, Joseph M. Ziegelbauer, Teijo Pellinen, Mark Bower, Mathias Francois, Päivi M. Ojala

Cancer Res. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: Cancer Res. 2020 Aug 1; 80(15): 3116–3129. Published online 2020 Jun 9. doi: 10.1158/0008-5472.CAN-19-3103

PMCID:: PMC8985843

Abstract Article PDF–2.3M

Select item 89741798.

Prospero homeobox 1 promotes proliferation, migration, and invasion of osteosarcoma cells and its clinical significance

Dawei Liu, Ran Wang, Yuefeng Wang, Ye Wang, Liantang Wang

Bioengineered. 2022; 13(2): 2259–2271. Published online 2022 Jan 14. doi: 10.1080/21655979.2021.2024330

PMCID:: PMC8974179

Abstract Article PDF–2.8M

Select item 89352339.

PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK

Lizhe Zhu, Qi Tian, Huan Gao, Kaijie Wu, Bo Wang, Guanqun Ge, Siyuan Jiang, Ke Wang, Can Zhou, Jianjun He, Peijun Liu, Yu Ren, Bin Wang

Int J Biol Sci. 2022; 18(5): 2032–2046. Published online 2022 Feb 28. doi: 10.7150/ijbs.68960

PMCID:: PMC8935233

Abstract Article PDF–5.8M

Select item 883406410.

PROX1, a Key Mediator of the Anti-Proliferative Effect of Rapamycin on Hepatocellular Carcinoma Cells

Sora Kwon, Kiwon Ban, Young-Kwon Hong, Jung-Suk Sung, Inho Choi

Cells. 2022 Feb; 11(3): 446. Published online 2022 Jan 27. doi: 10.3390/cells11030446

PMCID:: PMC8834064

Abstract Article PDF–5.9M

Select item 856581411.

Long non-coding RNA PROX1-AS1 knockdown upregulates microRNA-519d-3p to promote chemosensitivity of retinoblastoma cells via targeting SOX2

Yanyan Chen, Boyang Lu, Lei Liu, Xuefeng Pan, Chunying Jiang, Hui Xu

Cell Cycle. 2021; 20(20): 2149–2159. Published online 2021 Sep 29. doi: 10.1080/15384101.2021.1971352

PMCID:: PMC8565814

Abstract Article PDF–2.4M

Select item 844833712.

Kaposi’s sarcoma-associated herpesvirus promotes mesenchymal-to-endothelial transition by resolving the bivalent chromatin of PROX1 gene

Yao Ding, Weikang Chen, Zhengzhou Lu, Yan Wang, Yan Yuan

PLoS Pathog. 2021 Sep; 17(9): e1009847. Published online 2021 Sep 7. doi: 10.1371/journal.ppat.1009847

PMCID:: PMC8448337

Abstract Article PDF–3.4M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800904814.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 790504015.

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer

Hantao Wang, Junjie Xing, Wei Wang, Guifen Lv, Haiyan He, Yeqing Lu, Mei Sun, Haiyan Chen, Xu Li

Front Cell Dev Biol. 2020; 8: 601502. Published online 2021 Feb 11. doi: 10.3389/fcell.2020.601502

PMCID:: PMC7905040

Abstract Article PDF–3.2M

Select item 775914816.

The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus

Dongwon Choi, Eunkyung Park, Kyu Eui Kim, Eunson Jung, Young Jin Seong, Luping Zhao, Shrimika Madhavan, George Daghlian, Hansuh H. Lee, Patill T. Daghlian, Saren Daghlian, Khoa Bui, Chester J. Koh, Alex K. Wong, Il-Taeg Cho, Young-Kwon Hong

Cancer Res. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Cancer Res. 2020 Aug 1; 80(15): 3130–3144. Published online 2020 Jun 9. doi: 10.1158/0008-5472.CAN-19-3105

PMCID:: PMC7759148

Abstract Article PDF–3.2M

Select item 764586317.

N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease

Tomas Koudelka, Juliane Boger, Alessandra Henkel, Robert Schönherr, Stefanie Krantz, Sabine Fuchs, Estefanía Rodríguez, Lars Redecke, Andreas Tholey

Proteomics. 2021 Jan; 21(2): 2000246. Published online 2020 Nov 17. doi: 10.1002/pmic.202000246

PMCID:: PMC7645863

Abstract Article PDF–497K

Select item 754959618.

Two rare PROX1 variants in patients with lymphedema

Maurizio Ricci, Bruno Amato, Shila Barati, Rita Compagna, Dominika Veselenyiova, Sercan Kenanoglu, Liborio Stuppia, Tommaso Beccari, Mirko Baglivo, Danjela Kurti, Juraj Krajcovic, Roberta Serrani, Munis Dundar, Syed H. Basha, Pietro Chiurazzi, Matteo Bertelli

Mol Genet Genomic Med. 2020 Oct; 8(10): e1424. Published online 2020 Aug 5. doi: 10.1002/mgg3.1424

PMCID:: PMC7549596

Abstract Article PDF–998K

Select item 743811219.

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer

eLife. 2020; 9: e54993. Published online 2020 Aug 3. doi: 10.7554/eLife.54993