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Select item 106518581.

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

Madeline B. Searcy, Randolph K. Larsen, IV, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley

Nat Commun. 2023; 14: 7291. Published online 2023 Nov 15. doi: 10.1038/s41467-023-43044-1

PMCID:: PMC10651858

Abstract Article PDF–7.8M

Select item 101279092.

PAX3 基因新突变致Ⅰ型Waardenburg综合征家系基因型与表型特征分析

李霞, 赵声波, 毕先云, 娄凡, 曾文娟, 高燕, 毛志勇, 马静

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jul 5; 35(7): 621–626. Chinese. doi: 10.13201/j.issn.2096-7993.2021.07.010

PMCID:: PMC10127909

Abstract Article PDF–6.1M

Select item 97475603.

Identification of nine novel variants across PAX3, SOX10, EDNRB, and MITF genes in Waardenburg syndrome with next‐generation sequencing

Chen‐Yu Lee, Ming‐Yu Lo, You‐Mei Chen, Pei‐Hsuan Lin, Chuan‐Jen Hsu, Pei‐Lung Chen, Chen‐Chi Wu, Jacob Shujui Hsu

Mol Genet Genomic Med. 2022 Dec; 10(12): e2082. Published online 2022 Nov 4. doi: 10.1002/mgg3.2082

PMCID:: PMC9747560

Abstract Article PDF–1009K

Select item 93356054.

The Relationship Between Chimeric RNAs and Gene Fusions; Potential Implications of Reciprocity in Cancer

Justin Elfman, Lam-Phong Pham, Hui Li

J Genet Genomics. Author manuscript; available in PMC 2022 Jul 29.

Published in final edited form as: J Genet Genomics. 2020 Jul 20; 47(7): 341–348. Published online 2020 Jun 14. doi: 10.1016/j.jgg.2020.04.005

PMCID:: PMC9335605

Abstract Article PDF–790K

Select item 91664055.

Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

Line Manceau, Julien Richard Albert, Pier-Luigi Lollini, Maxim V. C. Greenberg, Pascale Gilardi-Hebenstreit, Vanessa Ribes

PLoS Genet. 2022 May; 18(5): e1009782. Published online 2022 May 23. doi: 10.1371/journal.pgen.1009782

PMCID:: PMC9166405

Abstract Article PDF–3.0M

Select item 84583996.

Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma

Takuyo Kanayama, Mitsuru Miyachi, Yohei Sugimoto, Shigeki Yagyu, Ken Kikuchi, Kunihiko Tsuchiya, Tomoko Iehara, Hajime Hosoi

Sci Rep. 2021; 11: 18802. Published online 2021 Sep 22. doi: 10.1038/s41598-021-98322-z

PMCID:: PMC8458399

Abstract Article PDF–1.7M

Select item 83216617.

Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma

Carla Regina, Ebrahem Hamed, Geoffroy Andrieux, Sina Angenendt, Michaela Schneider, Manching Ku, Marie Follo, Marco Wachtel, Eugene Ke, Ken Kikuchi, Anton G Henssen, Beat W Schäfer, Melanie Boerries, Amy J Wagers, Charles Keller, Simone Hettmer

Life Sci Alliance. 2021 Sep; 4(9): e202001002. Published online 2021 Jun 29. doi: 10.26508/lsa.202001002

PMCID:: PMC8321661

Abstract Article PDF–3.4M

Select item 81837358.

Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer

Doo Byung Chay, Gwan Hee Han, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung, Stephen M. Hewitt

Int J Clin Oncol. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Int J Clin Oncol. 2019 Nov; 24(11): 1429–1439. Published online 2019 Jul 13. doi: 10.1007/s10147-019-01507-w

PMCID:: PMC8183735

Abstract Article PDF–1.3M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800904810.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 800549211.

FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.

David Milewski, Samriddhi Shukla, Berkley E. Gryder, Arun Pradhan, Johnny Donovan, Parvathi Sudha, Sushmitha Vallabh, Athena Pyros, Yan Xu, Artem Barski, Sara Szabo, Brian Turpin, Joseph G. Pressey, Douglas P. Millay, Javed Khan, Vladimir V. Kalinichenko, Tanya V. Kalin

Oncogene. Author manuscript; available in PMC 2021 Aug 24.

Published in final edited form as: Oncogene. 2021 Mar; 40(12): 2182–2199. Published online 2021 Feb 24. doi: 10.1038/s41388-021-01694-9

PMCID:: PMC8005492

Abstract Article PDF–2.8M

Select item 780288512.

PAX3-FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability

Berkley E. Gryder, Marielle E. Yohe, Hsien-Chao Chou, Xiaohu Zhang, Joana Marques, Marco Wachtel, Beat Schaefer, Nirmalya Sen, Young Song, Alberto Gualtieri, Silvia Pomella, Rossella Rota, Abigail Cleveland, Xinyu Wen, Sivasish Sindiri, Jun S. Wei, Frederic G. Barr, Sudipto Das, Thorkell Andresson, Rajarshi Guha, Madhu Lal-Nag, Marc Ferrer, Jack F. Shern, Keji Zhao, Craig J. Thomas, Javed Khan

Cancer Discov. Author manuscript; available in PMC 2021 Jan 12.

Published in final edited form as: Cancer Discov. 2017 Aug; 7(8): 884–899. Published online 2017 Apr 26. doi: 10.1158/2159-8290.CD-16-1297

PMCID:: PMC7802885

Abstract Article PDF–1.2M

Select item 753078313.

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma

Lays M. Sobral, Hannah M. Hicks, Janet K. Parrish, Tyler S. McCann, Joseph Hsieh, Andrew Goodspeed, James C. Costello, Joshua C. Black, Paul Jedlicka

Mol Oncol. 2020 Oct; 14(10): 2471–2486. Published online 2020 Aug 5. doi: 10.1002/1878-0261.12769

PMCID:: PMC7530783

Abstract Article PDF–2.6M

Select item 737171514.

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie

Nat Commun. 2020; 11: 3627. Published online 2020 Jul 20. doi: 10.1038/s41467-020-17357-4

PMCID:: PMC7371715

Abstract Article PDF–10M

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 690504416.

Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer

Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim

BMC Cancer. 2019; 19: 1202. Published online 2019 Dec 10. doi: 10.1186/s12885-019-6406-6

PMCID:: PMC6905044

Abstract Article PDF–1.9M

Select item 677813717.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 677516318.

The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486

Farah Ghamloush, Sandra E. Ghayad, Ghina Rammal, Assil Fahs, Abeer J. Ayoub, Zeina Merabi, Mohamad Harajly, Hassan Zalzali, Raya Saab

Sci Rep. 2019; 9: 14242. Published online 2019 Oct 2. doi: 10.1038/s41598-019-50592-4

PMCID:: PMC6775163

Abstract Article PDF–4.6M

Select item 662515119.

A novel mutation of the PAX3 gene in a Chinese family with Waardenburg syndrome type I

Jing Ma, Ken Lin, Hong‐chao Jiang, Yanli Yang, Yu Zhang, Guilian Yang, Hao Sun, Cheng Ming, Xianyun Bi, Tiesong Zhang, Biao Ruan

Mol Genet Genomic Med. 2019 Jul; 7(7): e00798. Published online 2019 Jun 12. doi: 10.1002/mgg3.798

PMCID:: PMC6625151

Abstract Article PDF–1015K

Select item 662408320.

The expression and function of PAX3 in development and disease

Salah Boudjadi, Bishwanath Chatterjee, Wenyue Sun, Prasantha Vemu, Frederic G. Barr

Gene. Author manuscript; available in PMC 2019 Aug 5.

Published in final edited form as: Gene. 2018 Aug 5; 666: 145–157. Published online 2018 May 4. doi: 10.1016/j.gene.2018.04.087

PMCID:: PMC6624083

Abstract Article PDF–773K

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