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Select item 111675211.

Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo

Kevin Toussaint, Aline Appert-Collin, Laetitia Vanalderwiert, Camille Bour, Christine Terryn, Caroline Spenlé, Michaël Van Der Heyden, Mathilde Roumieux, Pascal Maurice, Béatrice Romier-Crouzet, Hervé Sartelet, Laurent Duca, Sébastien Blaise, Amar Bennasroune

J Biol Chem. 2024 Jun; 300(6): 107316. Published online 2024 Apr 23. doi: 10.1016/j.jbc.2024.107316

PMCID:: PMC11167521

Abstract Article PDF–2.4M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 106240713.

Therapeutic Potential of Neu1 in Alzheimer’s Disease Via the Immune System

Aiza Khan, Sumit Das, Consolato Sergi

Am J Alzheimers Dis Other Demen. 2021 Jan-Dec; 36: 1533317521996147. Published online 2021 Mar 15. doi: 10.1177/1533317521996147

PMCID:: PMC10624071

Abstract Article PDF–336K

Select item 103803814.

Deciphering the Action of Neuraminidase in Glioblastoma Models

Nathalie Baeza-Kallee, Raphaël Bergès, Victoria Hein, Stéphanie Cabaret, Jeremy Garcia, Abigaëlle Gros, Emeline Tabouret, Aurélie Tchoghandjian, Carole Colin, Dominique Figarella-Branger

Int J Mol Sci. 2023 Jul; 24(14): 11645. Published online 2023 Jul 19. doi: 10.3390/ijms241411645

PMCID:: PMC10380381

Abstract Article PDF–2.6M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98811366.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 97725587.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 95702128.

PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway

So Eun Youn, Fen Jiang, Hye Yun Won, Da Eun Hong, Tae Heung Kang, Yun-Yong Park, Sang Seok Koh

Int J Mol Sci. 2022 Oct; 23(19): 11414. Published online 2022 Sep 27. doi: 10.3390/ijms231911414

PMCID:: PMC9570212

Abstract Article PDF–3.9M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 923162310.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 917141111.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 905466112.

Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Daniel J. García-Domínguez, Nabil Hajji, Roser López-Alemany, Sara Sánchez-Molina, Elisabet Figuerola-Bou, Francisco J. Morón Civanto, Santiago Rello-Varona, Eduardo Andrés-León, Adrián Benito, Hector C. Keun, Jaume Mora, Óscar M. Tirado, Enrique de Álava, Lourdes Hontecillas-Prieto

Oncogene. 2022; 41(18): 2638–2650. Published online 2022 Mar 30. doi: 10.1038/s41388-022-02279-w

PMCID:: PMC9054661

Abstract Article PDF–5.4M

Select item 889702213.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 874895814.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 865048815.

Discovery of NEU1 as a candidate renal biomarker for proliferative lupus nephritis chronicity

Zhaomin Mao, Ying Tan, Feng Yu, Minghui Zhao

Lupus Sci Med. 2021; 8(1): e000569. Published online 2021 Dec 5. doi: 10.1136/lupus-2021-000569

PMCID:: PMC8650488

Abstract Article PDF–3.6M

Select item 863302716.

Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension

Monika Lakk, Grace F. Hoffmann, Aruna Gorusupudi, Eric Enyong, Amy Lin, Paul S. Bernstein, Trine Toft-Bertelsen, Nanna MacAulay, Michael H. Elliott, David Križaj

J Lipid Res. 2021; 62: 100145. Published online 2021 Oct 25. doi: 10.1016/j.jlr.2021.100145

PMCID:: PMC8633027

Abstract Article PDF–3.6M

Select item 859135817.

The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling

Sang W. Hyun, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum, Erik P. Lillehoj

J Biol Chem. 2021 Nov; 297(5): 101337. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101337

PMCID:: PMC8591358

Abstract Article PDF–1.8M

Select item 855290718.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 846261919.

Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

Yung-Chih Cheng, Andrew Snavely, Lee B. Barrett, Xuefei Zhang, Crystal Herman, Devlin J. Frost, Priscilla Riva, Ivan Tochitsky, Riki Kawaguchi, Bhagat Singh, Jelena Ivanis, Eric A. Huebner, Anthony Arvanites, Vatsal Oza, Lance Davidow, Rie Maeda, Miyuki Sakuma, Alyssa Grantham, Qing Wang, Amelia N. Chang, Kathleen Pfaff, Michael Costigan, Giovanni Coppola, Lee L. Rubin, Bjoern Schwer, Frederick W. Alt, Clifford J. Woolf

Cell Rep. Author manuscript; available in PMC 2021 Sep 24.

Published in final edited form as: Cell Rep. 2021 Sep 7; 36(10): 109666. doi: 10.1016/j.celrep.2021.109666

PMCID:: PMC8462619

Abstract Article PDF–1.5M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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