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Select item 106073181.

The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes

Anne Kayser, Sven Dittmann, Tomo Šarić, Giulia Mearini, Arie O. Verkerk, Eric Schulze-Bahr

Int J Mol Sci. 2023 Oct; 24(20): 15290. Published online 2023 Oct 18. doi: 10.3390/ijms242015290

PMCID:: PMC10607318

Abstract Article PDF–2.2M

Select item 100254752.

Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism

Yi-Yao Chang, Bo-Ching Lee, Zheng-Wei Chen, Cheng-Hsuan Tsai, Chin-Chen Chang, Che-Wei Liao, Chien-Ting Pan, Kang-Yung Peng, Chia-Hung Chou, Ching-Chu Lu, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin, TAIPAI study group

Front Endocrinol (Lausanne) 2023; 14: 1061704. Published online 2023 Mar 6. doi: 10.3389/fendo.2023.1061704

PMCID:: PMC10025475

Abstract Article PDF–4.1M

Select item 97615693.

Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults

Kazutaka Nanba, Jessica E Baker, Amy R Blinder, Nolan R Bick, Chia-Jen Liu, Jung Soo Lim, Heather Wachtel, Debbie L Cohen, Tracy Ann Williams, Martin Reincke, Melanie L Lyden, Irina Bancos, William F Young, Tobias Else, Thomas J Giordano, Aaron M Udager, William E Rainey

J Clin Endocrinol Metab. 2022 Sep; 107(9): 2473–2482. Published online 2022 Jul 2. doi: 10.1210/clinem/dgac408

PMCID:: PMC9761569

Abstract Article

Select item 95691334.

Insight into the phospholipid binding preferences of Kir3.4

Pei Qiao, Samantha Schrecke, Jixing Lyu, Yun Zhu, Tianqi Zhang, Amanda Benavides, Arthur Laganowsky

Biochemistry. Author manuscript; available in PMC 2022 Oct 15.

Published in final edited form as: Biochemistry. 2021 Dec 21; 60(50): 3813–3821. Published online 2021 Nov 30. doi: 10.1021/acs.biochem.1c00615

PMCID:: PMC9569133

Abstract Article PDF–1.1M

Select item 94094695.

Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma

Takumi Kitamoto, Tetsuo Nishikawa

Int J Mol Sci. 2022 Aug; 23(16): 9042. Published online 2022 Aug 12. doi: 10.3390/ijms23169042

PMCID:: PMC9409469

Abstract Article PDF–1.0M

Select item 89244846.

KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma

Bo-Ching Lee, Victor Jing-Wei Kang, Chien-Ting Pan, Jia-Zheng Huang, Yu-Li Lin, Yi-Yao Chang, Cheng-Hsuan Tsai, Chia-Hung Chou, Zheng-Wei Chen, Che-Wei Liao, Yu-Wei Chiu, Vin-Cent Wu, Chi-Sheng Hung, Chin-Chen Chang, Yen-Hung Lin

Front Endocrinol (Lausanne) 2022; 13: 830130. Published online 2022 Mar 2. doi: 10.3389/fendo.2022.830130

PMCID:: PMC8924484

Abstract Article PDF–355K

Select item 83217927.

Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH

John J. Enyeart, Judith A. Enyeart

Am J Physiol Cell Physiol. 2021 Jul 1; 321(1): C158–C175. Published online 2021 May 26. doi: 10.1152/ajpcell.00118.2021

PMCID:: PMC8321792

Abstract Article

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 700456510.

Nucleotide inhibition of the pancreatic ATP-sensitive K⁺ channel explored with patch-clamp fluorometry

Samuel G Usher, Frances M Ashcroft, Michael C Puljung

eLife. 2020; 9: e52775. Published online 2020 Jan 7. doi: 10.7554/eLife.52775

PMCID:: PMC7004565

Abstract Article PDF–3.9M

Select item 675998811.

Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma

Yuto Yamazaki, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Yuzu Adachi, Kazue Ise, Yasuhiro Nakamura, Celso E. Gomez-Sanchez, Yukiko Shibahara, Takumi Kitamoto, Tetsuo Nishikawa, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano

Hypertension. Author manuscript; available in PMC 2019 Sep 25.

Published in final edited form as: Hypertension. 2018 Sep; 72(3): 632–640. doi: 10.1161/HYPERTENSIONAHA.118.10907

PMCID:: PMC6759988

Abstract Article PDF–1.4M

Select item 675891012.

18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status

Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Koji Mitsuzuka, Akihiro Ito, Jun Nishikawa, Noriko Asai, Yasuhiro Nakamura, Celso E. Gomez-Sanchez, Sadayoshi Ito, Mari Dezawa, Hironobu Sasano, Fumitoshi Satoh

Hypertension. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Hypertension. 2019 Jun; 73(6): 1283–1290. doi: 10.1161/HYPERTENSIONAHA.118.12064

PMCID:: PMC6758910

Abstract Article PDF–488K

Select item 673916813.

PRIMARY ALDOSTERONISM: KCNJ5 MUTATIONS AND ADRENOCORTICAL CELL GROWTH

Yuhong Yang, Celso E. Gomez-Sanchez, Diana Jaquin, Elke Tatjana Aristizabal Prada, Lucie S. Meyer, Thomas Knösel, Holger Schneider, Felix Beuschlein, Martin Reincke, Tracy Ann Williams

Hypertension. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Hypertension. 2019 Oct; 74(4): 809–816. Published online 2019 Aug 26. doi: 10.1161/HYPERTENSIONAHA.119.13476

PMCID:: PMC6739168

Abstract Article PDF–1.4M

Select item 657879614.

A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels

A Spauschus, KU Lentes, E Wischmeyer, E Dissmann, C Karschin, A Karschin

J Neurosci. 1996 Feb 1; 16(3): 930–938. doi: 10.1523/JNEUROSCI.16-03-00930.1996

PMCID:: PMC6578796

Abstract PDF–2.4M

Select item 620720915.

CELLULAR AND GENETIC CAUSES OF IDIOPATHIC HYPERALDOSTERONISM

Kei Omata, Fumitoshi Satoh, Ryo Morimoto, Sadayoshi Ito, Yuto Yamazaki, Yasuhiro Nakamura, Sharath K. Anand, Zeng Guo, Michael Stowasser, Hironobu Sasano, Scott A. Tomlins, William E. Rainey

Hypertension. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Hypertension. 2018 Oct; 72(4): 874–880. doi: 10.1161/HYPERTENSIONAHA.118.11086

PMCID:: PMC6207209

Abstract Article PDF–573K

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549075717.

Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

Ute I. Scholl, Laura Abriola, Chengbiao Zhang, Esther N. Reimer, Mark Plummer, Barbara I. Kazmierczak, Junhui Zhang, Denton Hoyer, Jane S. Merkel, Wenhui Wang, Richard P. Lifton

J Clin Invest. 2017 Jun 30; 127(7): 2739–2750. Published online 2017 Jun 12. doi: 10.1172/JCI91733

PMCID:: PMC5490757

Abstract Article PDF–1.3M

Select item 548290418.

Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism

Ai Tamura, Koshiro Nishimoto, Tsugio Seki, Yoko Matsuzawa, Jun Saito, Masao Omura, Celso E. Gomez-Sanchez, Kohzoh Makita, Seishi Matsui, Nobukazu Moriya, Atsushi Inoue, Maki Nagata, Hironobu Sasano, Yasuhiro Nakamura, Yuto Yamazaki, Yasuaki Kabe, Kuniaki Mukai, Takeo Kosaka, Mototsugu Oya, Sachiko Suematsu, Tetsuo Nishikawa

Mol Cell Endocrinol. Author manuscript; available in PMC 2018 Feb 5.

Published in final edited form as: Mol Cell Endocrinol. 2017 Feb 5; 441: 134–139. Published online 2016 Aug 8. doi: 10.1016/j.mce.2016.07.031

PMCID:: PMC5482904

Abstract Article PDF–1.0M

Select item 544471919.

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Chia-Hui Chang, Ya-Hui Hu, Yao-Chou Tsai, Che-Hsiung Wu, Shuo-Meng Wang, Lian-Yu Lin, Yen-Hung Lin, Fumitoshi Satoh, Kwan-Dun Wu, Vin-Cent Wu

Oncotarget. 2017 May 2; 8(18): 29984–29995. Published online 2017 Mar 16. doi: 10.18632/oncotarget.16269

PMCID:: PMC5444719

Abstract Article PDF–4.7M

Select item 541467720.

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells

Iris Hardege, Shengxin Xu, Richard D. Gordon, Andrew J. Thompson, Nichola Figg, Michael Stowasser, Ruth Murrell-Lagnado, Kevin M. O'Shaughnessy

Mol Endocrinol. 2015 Oct; 29(10): 1522–1530. Published online 2015 Sep 4. doi: 10.1210/me.2015-1195

PMCID:: PMC5414677

Abstract Article

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