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Select item 109787351.

Functional analysis of a first hindlimb positioning enhancer via Gdf11 expression

Seiji Saito, Utsugi Kanazawa, Ayana Tatsumi, Atsuo Iida, Tatsuya Takemoto, Takayuki Suzuki

Front Cell Dev Biol. 2024; 12: 1302141. Published online 2024 Mar 15. doi: 10.3389/fcell.2024.1302141

PMCID:: PMC10978735

Abstract Article PDF–3.4M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107575853.

Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans

Simon Kraler, Carolina Balbi, Daria Vdovenko, Tetiana Lapikova-Bryhinska, Giovanni G Camici, Luca Liberale, Nicole Bonetti, Candela Diaz Canestro, Fabienne Burger, Aline Roth, Federico Carbone, Giuseppe Vassalli, François Mach, Shalender Bhasin, Florian A Wenzl, Olivier Muller, Lorenz Räber, Christian M Matter, Fabrizio Montecucco, Thomas F Lüscher, Alexander Akhmedov

Cardiovasc Res. 2023 Dec; 119(17): 2729–2742. Published online 2023 Sep 23. doi: 10.1093/cvr/cvad153

PMCID:: PMC10757585

Abstract Article PDF–7.2M

Select item 106564444.

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

Di-Xian Wang, Zhao-Jun Dong, Sui-Xin Deng, Ying-Ming Tian, Yu-Jie Xiao, Xinran Li, Xiao-Ru Ma, Liang Li, Pengxiao Li, Hui-Zhong Chang, Longqi Liu, Fan Wang, Yang Wu, Xiang Gao, Shuang-Shuang Zheng, Hui-Min Gu, Ya-Nan Zhang, Jian-Bin Wu, Fan Wu, Yonglin Peng, Xiao-Wen Zhang, Ren-Ya Zhan, Li-Xia Gao, Qiming Sun, Xing Guo, Xiao-Dong Zhao, Jian-Hong Luo, Ruhong Zhou, Lei Han, Yousheng Shu, Jing-Wei Zhao

Nat Commun. 2023; 14: 7476. Published online 2023 Nov 17. doi: 10.1038/s41467-023-43292-1

PMCID:: PMC10656444

Abstract Article PDF–14M

Select item 101541975.

Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy

Carine Moigneu, Soumia Abdellaoui, Mariana Ramos-Brossier, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Taiane de Azevedo Cardoso, Claire Camus, Aurélie Chiche, Nicolas Kuperwasser, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira, Han Li, Franck Oury, Flávio Kapczinski, Pierre-Marie Lledo, Lida Katsimpardi

Nat Aging. 2023; 3(2): 213–228. Published online 2023 Feb 2. doi: 10.1038/s43587-022-00352-3

Correction in:: Nat Aging. 2023; 3(8): 1036.

PMCID:: PMC10154197

Abstract Article PDF–5.6M

Select item 99772836.

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y Zoghbi

eLife. 2023; 12: e83806. Published online 2023 Feb 27. doi: 10.7554/eLife.83806

PMCID:: PMC9977283

Abstract Article PDF–3.4M

Select item 98346637.

Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle

John Lian, Ryan G Walker, Andrea D’Amico, Ana Vujic, Melanie J Mills, Kathleen A Messemer, Kourtney R Mendello, Jill M Goldstein, Krystynne A Leacock, Soraya Epp, Emma V Stimpfl, Thomas B Thompson, Amy J Wagers, Richard T Lee

Life Sci Alliance. 2023 Mar; 6(3): e202201662. Published online 2023 Jan 11. doi: 10.26508/lsa.202201662

PMCID:: PMC9834663

Abstract Article PDF–3.3M

Select item 97552678.

Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

Yi-Cheng Chang, Jan Manent, Jan Schroeder, Siew Fen Lisa Wong, Gabriel M. Hauswirth, Natalia A. Shylo, Emma L. Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Paul Trainor, Edwina McGlinn

Nat Commun. 2022; 13: 7766. Published online 2022 Dec 15. doi: 10.1038/s41467-022-35303-4

PMCID:: PMC9755267

Abstract Article PDF–2.9M

Select item 95287609.

GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways

Jan Frohlich, Kristina Kovacovicova, Marco Raffaele, Tereza Virglova, Eliska Cizkova, Jan Kucera, Julie Bienertova‐Vasku, Martin Wabitsch, Marion Peyrou, Francesca Bonomini, Rita Rezzani, George N. Chaldakov, Anton B. Tonchev, Michelino Di Rosa, Nicolas Blavet, Vaclav Hejret, Manlio Vinciguerra

Cell Prolif. 2022 Oct; 55(10): e13310. Published online 2022 Aug 3. doi: 10.1111/cpr.13310

PMCID:: PMC9528760

Abstract Article PDF–3.7M

Select item 876101110.

Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy

Jian Sun, Ying Li, Xiao Yang, Wei Dong, Jiankun Yang, Qi Hu, Cuntai Zhang, Haoshu Fang, Anding Liu

Aging Cell. 2022 Jan; 21(1): e13532. Published online 2021 Dec 14. doi: 10.1111/acel.13532

PMCID:: PMC8761011

Abstract Article PDF–1.6M

Select item 875267411.

Breaking constraint of mammalian axial formulae

Gabriel M. Hauswirth, Victoria C. Garside, Lisa S. F. Wong, Heidi Bildsoe, Jan Manent, Yi-Cheng Chang, Christian M. Nefzger, Jaber Firas, Joseph Chen, Fernando J. Rossello, Jose M. Polo, Edwina McGlinn

Nat Commun. 2022; 13: 243. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27335-z

PMCID:: PMC8752674

Abstract Article PDF–4.8M

Select item 852752012.

A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin

Abigail E Starcher, Kristen Peissig, James B Stanton, Gary A Churchill, Dunpeng Cai, Joshua T Maxwell, Arthur Grider, Kim Love, Shi-You Chen, Amanda E Coleman, Emma Strauss, Robert Pazdro

G3 (Bethesda) 2021 Nov; 11(11): jkab293. Published online 2021 Sep 2. doi: 10.1093/g3journal/jkab293

PMCID:: PMC8527520

Abstract Article PDF–762K

Select item 842266913.

GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin

Mol Brain. 2021; 14: 134. Published online 2021 Sep 6. doi: 10.1186/s13041-021-00845-z

PMCID:: PMC8422669

Abstract Article PDF–2.2M

Select item 825377414.

Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity

Lin Chen, Guangjin Luo, Yameng Liu, Hairuo Lin, Cankun Zheng, Dongxiao Xie, Yingqi Zhu, Lu Chen, Xiaoxia Huang, Donghong Hu, Jiahe Xie, Zhenhuan Chen, Wangjun Liao, Jianping Bin, Qiancheng Wang, Yulin Liao

Cell Death Dis. 2021 Jul; 12(7): 665. Published online 2021 Jul 2. doi: 10.1038/s41419-021-03954-8

PMCID:: PMC8253774

Abstract Article PDF–3.3M

Select item 793560615.

PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model

Fangfang Dou, Beiling Wu, Jiulin Chen, Te Liu, Zhihua Yu, Chuan Chen

Oxid Med Cell Longev. 2021; 2021: 2045259. Published online 2021 Feb 25. doi: 10.1155/2021/2045259

PMCID:: PMC7935606

Abstract Article PDF–3.2M

Select item 773289516.

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

Jan Frohlich, Manlio Vinciguerra

GeroScience. 2020 Dec; 42(6): 1475–1498. Published online 2020 Oct 6. doi: 10.1007/s11357-020-00279-w

PMCID:: PMC7732895

Abstract Article PDF–814K

Select item 773056117.

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

Michael Dussiot, Thiago T Maciel, Aurélie Fricot, Céline Chartier, Olivier Negre, Joel Veiga, Damien Grapton, Etienne Paubelle, Emmanuel Payen, Yves Beuzard, Philippe Leboulch, Jean-Antoine Ribeil, Jean-Benoit Arlet, Francine Coté, Geneviève Courtois, Yelena Z Ginzburg, Thomas O Daniel, Rajesh Chopra, Victoria Sung, Olivier Hermine, Ivan C Moura

Nat Med. Author manuscript; available in PMC 2020 Dec 11.

Published in final edited form as: Nat Med. 2014 Apr; 20(4): 398–407. Published online 2014 Mar 23. doi: 10.1038/nm.3468

PMCID:: PMC7730561

Abstract Article PDF–3.0M

Select item 757626918.

Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells

Xingying Qi, Qingyue Xiao, Rui Sheng, Shuang Jiang, Quan Yuan, Weiqing Liu

J Cell Mol Med. 2020 Oct; 24(19): 11457–11464. Published online 2020 Aug 26. doi: 10.1111/jcmm.15754

PMCID:: PMC7576269

Abstract Article PDF–875K

Select item 741268819.

Growth differentiation factor 11 promotes differentiation of MSCs into endothelial‐like cells for angiogenesis

Chi Zhang, Yinuo Lin, Qi Liu, Junhua He, Pingping Xiang, Dianliang Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu

J Cell Mol Med. 2020 Aug; 24(15): 8703–8717. Published online 2020 Jun 25. doi: 10.1111/jcmm.15502

PMCID:: PMC7412688

Abstract Article PDF–2.9M

Select item 732415920.

A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

André Dias, Anastasiia Lozovska, Filip J Wymeersch, Ana Nóvoa, Anahi Binagui-Casas, Daniel Sobral, Gabriel G Martins, Valerie Wilson, Moises Mallo

eLife. 2020; 9: e56615. Published online 2020 Jun 29. doi: 10.7554/eLife.56615

PMCID:: PMC7324159

Abstract Article PDF–16M

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