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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106311132.

GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells

Wenqin Xu, Xiaocui Ma, Qing Wang, Jingjing Ye, Nengqian Wang, Zhenzhen Ye, Tianbing Chen

Cell Mol Biol Lett. 2023; 28: 90. Published online 2023 Nov 7. doi: 10.1186/s11658-023-00506-0

PMCID:: PMC10631113

Abstract Article PDF–3.5M

Select item 98520723.

The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis

Kaiyuan Wu, Jizhong Zou, Michael N. Sack

Biochem Biophys Res Commun. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Biochem Biophys Res Commun. 2023 Jan 29; 642: 1–10. Published online 2022 Dec 14. doi: 10.1016/j.bbrc.2022.12.038

PMCID:: PMC9852072

Abstract Article PDF–2.2M

Select item 97243934.

GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury

Tingting Lv, Yu Zhang, XingZhao Ji, Shengnan Sun, Li Xu, Weixia Ma, Yi Liu, Qiang Wan

J Transl Med. 2022; 20: 571. Published online 2022 Dec 6. doi: 10.1186/s12967-022-03782-0

PMCID:: PMC9724393

Abstract Article PDF–5.8M

Select item 93504695.

GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation

Dharendra Thapa, Paramesha Bugga, Bellina A. S. Mushala, Janet R. Manning, Michael W. Stoner, Brenda McMahon, Xuemei Zeng, Pamela S. Cantrell, Nathan Yates, Bingxian Xie, Lia R. Edmunds, Michael J. Jurczak, Iain Scott

Physiol Rep. 2022 Aug; 10(15): e15415. Published online 2022 Aug 3. doi: 10.14814/phy2.15415

PMCID:: PMC9350469

Abstract Article PDF–1.0M

Select item 90919866.

Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma

Taotao Zhang, Yunlong Cui, Yanjin Wu, Jiahui Meng, Linmeng Han, Jiaqi Zhang, Chunyu Zhang, Chenxi Yang, Lu Chen, Xue Bai, Kai Zhang, Kaiyuan Wu, Michael N. Sack, Lingdi Wang, Lu Zhu

Clin Transl Med. 2022 May; 12(5): e852. Published online 2022 May 11. doi: 10.1002/ctm2.852

PMCID:: PMC9091986

Abstract Article PDF–2.9M

Select item 86323257.

BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation

Kaiyuan Wu, Allen Seylani, Jing Wu, Xufeng Wu, Christopher K.E Bleck, Michael N Sack

Autophagy. 2021; 17(11): 3707–3724. Published online 2021 Mar 11. doi: 10.1080/15548627.2021.1894759

PMCID:: PMC8632325

Abstract Article PDF–32M

Select item 79068188.

General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease

Tingting Lv, Yao Lu, Yi Liu, Hong Feng, Chensheng Li, Wei Sheng, Zhengguo Cui, Suwei Zhu, Xia Gu, Zhe Yang, Qiang Wan

Oxid Med Cell Longev. 2021; 2021: 6691226. Published online 2021 Feb 17. doi: 10.1155/2021/6691226

PMCID:: PMC7906818

Abstract Article PDF–5.3M

Select item 76883139.

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

Chang Zhang, Chanjuan Hao, Guanghou Shui, Wei Li

eLife. 2020; 9: e58069. Published online 2020 Nov 12. doi: 10.7554/eLife.58069

PMCID:: PMC7688313

Abstract Article PDF–9.8M

Select item 746172610.

Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1

Iain Scott, Bradley R. Webster, Jian H. Li, Michael N. Sack

Biochem J. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Biochem J. 2012 May 1; 443(3): 655–661. doi: 10.1042/BJ20120118

PMCID:: PMC7461726

Abstract Article PDF–1.7M

Select item 732690811.

Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet

Dharendra Thapa, Janet R. Manning, Michael W. Stoner, Manling Zhang, Bingxian Xie, Iain Scott

Sci Rep. 2020; 10: 10665. Published online 2020 Jun 30. doi: 10.1038/s41598-020-67812-x

PMCID:: PMC7326908

Abstract Article PDF–2.0M

Select item 677156612.

Biogenesis of lysosome‐related organelles complex‐1 (BORC) regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate

Teodor E. Yordanov, Victoria E. B. Hipolito, Gudrun Liebscher, Georg F. Vogel, Taras Stasyk, Caroline Herrmann, Stephan Geley, David Teis, Roberto J. Botelho, Michael W. Hess, Lukas A. Huber

Traffic. 2019 Sep; 20(9): 674–696. Published online 2019 Aug 19. doi: 10.1111/tra.12679

PMCID:: PMC6771566

Abstract Article PDF–33M

Select item 663632713.

Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling

Janet R. Manning, Dharendra Thapa, Manling Zhang, Michael W. Stoner, Javier Traba, Catherine Corey, Sruti Shiva, Michael N. Sack, Iain Scott

Biochem J. Author manuscript; available in PMC 2020 Jun 19.

Published in final edited form as: Biochem J. 2019 Jun 19; 476(12): 1713–1724. Published online 2019 Jun 19. doi: 10.1042/BCJ20190302

PMCID:: PMC6636327

Abstract Article PDF–1.1M

Select item 648684314.

CARDIAC-SPECIFIC DELETION OF GCN5L1 RESTRICTS RECOVERY FROM ISCHEMIA-REPERFUSION INJURY

Janet R Manning, Dharendra Thapa, Manling Zhang, Michael W Stoner, Javier Traba, Charles F. McTiernan, Catherine Corey, Sruti Shiva, Michael N Sack, Iain Scott

J Mol Cell Cardiol. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2019 Apr; 129: 69–78. Published online 2019 Feb 15. doi: 10.1016/j.yjmcc.2019.02.009

PMCID:: PMC6486843

Abstract Article PDF–1.0M

Select item 644684115.

Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress

Donghwi Bae, Kristin A. Moore, Jessica M. Mella, Samantha Y. Hayashi, Julie Hollien

J Cell Biol. 2019 Apr 1; 218(4): 1118–1127. Published online 2019 Feb 20. doi: 10.1083/jcb.201809027

PMCID:: PMC6446841

Abstract Article PDF–2.4M

Select item 626277316.

GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking

Kaiyuan Wu, Lingdi Wang, Yong Chen, Mehdi Pirooznia, Komudi Singh, Sarah Wälde, Ralph H. Kehlenbach, Iain Scott, Marjan Gucek, Michael N. Sack

J Cell Sci. 2018 Nov 15; 131(22): jcs221036. Published online 2018 Nov 20. doi: 10.1242/jcs.221036

PMCID:: PMC6262773

Abstract Article

Select item 624087917.

The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA

Dharendra Thapa, Kaiyuan Wu, Michael W. Stoner, Bingxian Xie, Manling Zhang, Janet R. Manning, Zhongping Lu, Jian H. Li, Yong Chen, Marjan Gucek, Martin P. Playford, Nehal N. Mehta, Daniel Harmon, Robert M. O'Doherty, Michael J. Jurczak, Michael N. Sack, Iain Scott

J Biol Chem. 2018 Nov 16; 293(46): 17676–17684. Published online 2018 Oct 15. doi: 10.1074/jbc.AC118.005462

PMCID:: PMC6240879

Abstract Article PDF–1.9M

Select item 559582618.

GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

Lingdi Wang, Iain Scott, Lu Zhu, Kaiyuan Wu, Kim Han, Yong Chen, Marjan Gucek, Michael N. Sack

Nat Commun. 2017; 8: 523. Published online 2017 Sep 12. doi: 10.1038/s41467-017-00521-8

PMCID:: PMC5595826

Abstract Article PDF–1.2M

Select item 558291919.

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart

Dharendra Thapa, Manling Zhang, Janet R. Manning, Danielle A. Guimarães, Michael W. Stoner, Robert M. O’Doherty, Sruti Shiva, Iain Scott

Am J Physiol Heart Circ Physiol. 2017 Aug 1; 313(2): H265–H274. Published online 2017 May 19. doi: 10.1152/ajpheart.00752.2016

PMCID:: PMC5582919

Abstract Article

Select item 537624120.

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Valerio Donato, Massimo Bonora, Daniele Simoneschi, Davide Sartini, Yasusei Kudo, Anita Saraf, Laurence Florens, Michael P. Washburn, Matthias Stadtfeld, Paolo Pinton, Michele Pagano

Nat Cell Biol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Cell Biol. 2017 Apr; 19(4): 341–351. Published online 2017 Mar 20. doi: 10.1038/ncb3491

PMCID:: PMC5376241

Abstract Article PDF–2.4M

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PREDICTED: Homo sapiens fibrinogen like 1 (FGL1), transcript variant X1, mRNA
PREDICTED: Homo sapiens fibrinogen like 1 (FGL1), transcript variant X1, mRNA
gi|2217371382|ref|XM_047421577.1|

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