PMC Links for GEO Profiles (Select 122077159) - PMC

Joshua R. Barton, Annie K. Londregan, Tyler D. Alexander, Ariana A. Entezari, Shely Bar-Ad, Lan Cheng, Angelo C. Lepore, Adam E. Snook, Manuel Covarrubias, Scott A. Waldman

J Clin Invest. 2023 Feb 15; 133(4): e165578. Published online 2023 Feb 15. doi: 10.1172/JCI165578

PMCID:: PMC9927949

Abstract Article PDF–11M

Select item 83846994.

Metabolic syndrome mediates ROS-miR-193b-NFYA-dependent down regulation of sGC and contributes to exercise-induced pulmonary hypertension in HFpEF

Taijyu Satoh, Longfei Wang, Cristina Espinosa-Diez, Bing Wang, Scott A. Hahn, Kentaro Noda, Elizabeth R. Rochon, Matthew R. Dent, Andrea Levine, Jeffrey J. Baust, Samuel Wyman, Yijen L. Wu, Georgios A. Triantafyllou, Ying Tang, Mike Reynolds, Sruti Shiva, Cynthia St Hilaire, Delphine Gomez, Dmitry A. Goncharov, Elena A. Goncharova, Stephen Y. Chan, Adam C. Straub, Yen-Chun Lai, Charles F. McTiernan, Mark T. Gladwin

Circulation. Author manuscript; available in PMC 2022 Aug 24.

Published in final edited form as: Circulation. 2021 Aug 24; 144(8): 615–637. Published online 2021 Jun 23. doi: 10.1161/CIRCULATIONAHA.121.053889

PMCID:: PMC8384699

Abstract Article PDF–4.2M

Select item 82519255.

Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach

Rachel M. Wolfe, Al‐Walid Mohsen, Cate Walsh Vockley, Carol A. Bertrand, Robert D. Nicholls, Paige Heiman, Leah M. Seibold, Jerry Vockley, Lina Ghaloul‐Gonzalez

Am J Med Genet A. 2021 Jul; 185(7): 2046–2055. Published online 2021 May 5. doi: 10.1002/ajmg.a.62207

PMCID:: PMC8251925

Abstract Article PDF–2.0M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76114797.

Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations

Avipsa Bose, Sanghita Banerjee, Sandhya S. Visweswariah

IUBMB Life. Author manuscript; available in PMC 2021 Aug 11.

Published in final edited form as: IUBMB Life. 2020 Jun 1; 72(6): 1145–1159. Published online 2020 Apr 15. doi: 10.1002/iub.2283

PMCID:: PMC7611479

Abstract Article PDF–2.1M

Select item 75154558.

Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity

Amanda M. Pattison, Joshua R. Barton, Ariana A. Entezari, Alicja Zalewski, Jeff A. Rappaport, Adam E. Snook, Scott A. Waldman

Cancer Biol Ther. 2020; 21(9): 799–805. Published online 2020 Jun 28. doi: 10.1080/15384047.2020.1779005

PMCID:: PMC7515455

Abstract Article PDF–3.4M

Select item 67787239.

Two Distinct GUCY2C Circuits with PMV (Hypothalamic) and SN/VTA (Midbrain) Origin

D.J. Merlino, J.R. Barton, B.A. Charsar, M. Byrne, J.A. Rappaport, R.J. Smeyne, A.C. Lepore, A. E. Snook, S.A. Waldman

Brain Struct Funct. Author manuscript; available in PMC 2020 Nov 1.

Published in final edited form as: Brain Struct Funct. 2019 Nov; 224(8): 2983–2999. Published online 2019 Sep 4. doi: 10.1007/s00429-019-01949-y

PMCID:: PMC6778723

Abstract Article PDF–2.0M

Select item 593220710.

Human GUCY2C-targeted chimeric antigen receptor (CAR)-expressing T cells eliminate colorectal cancer metastases

Michael S. Magee, Tara S. Abraham, Trevor R. Baybutt, John C. Flickinger, Jr., Natalie A. Ridge, Glen P. Marszalowicz, Priyanka Prajapati, Adam R. Hersperger, Scott A. Waldman, Adam E. Snook

Cancer Immunol Res. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Cancer Immunol Res. 2018 May; 6(5): 509–516. Published online 2018 Apr 3. doi: 10.1158/2326-6066.CIR-16-0362

PMCID:: PMC5932207

Abstract Article PDF–1.3M

Select item 573621811.

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

Hadi Danaee, Thea Kalebic, Timothy Wyant, Matteo Fassan, Claudia Mescoli, Feng Gao, William L. Trepicchio, Massimo Rugge

PLoS One. 2017; 12(12): e0189953. Published online 2017 Dec 19. doi: 10.1371/journal.pone.0189953

PMCID:: PMC5736218

Abstract Article PDF–12M

Select item 561978212.

Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation

Hilde L. von Volkmann, Ingeborg Brønstad, Odd Helge Gilja, Rune R. Tronstad, Dag Andre Sangnes, Ragnar Nortvedt, Trygve Hausken, Georg Dimcevski, Torunn Fiskerstrand, Kim Nylund

PLoS One. 2017; 12(9): e0185496. Published online 2017 Sep 28. doi: 10.1371/journal.pone.0185496

PMCID:: PMC5619782

Abstract Article PDF–9.4M

Select item 550357613.

Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients

Yong Liu, Guoping Cheng, Jun Qian, HaiXing Ju, YuPing Zhu, Meucci Stefano, Ulrich Keilholz, DeChuan Li

Oncotarget. 2017 Jun 13; 8(24): 38841–38849. Published online 2017 Mar 21. doi: 10.18632/oncotarget.16406

PMCID:: PMC5503576

Abstract Article PDF–4.5M

Select item 517542314.

Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope

Adam E. Snook, Trevor R. Baybutt, Terry Hyslop, Scott A. Waldman

Hum Gene Ther Methods. 2016 Dec 1; 27(6): 238–250. Published online 2016 Dec 1. doi: 10.1089/hgtb.2016.114

PMCID:: PMC5175423

Abstract Article PDF–781K

Select item 497582915.

Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C

Thomas Müller, Insha Rasool, Peter Heinz-Erian, Eva Mildenberger, Christian Hülstrunk, Andreas Müller, Laurent Michaud, Bart G P Koot, Antje Ballauff, Julia Vodopiutz, Stefan Rosipal, Britt-Sabina Petersen, Andre Franke, Irene Fuchs, Heiko Witt, Heinz Zoller, Andreas R Janecke, Sandhya S Visweswariah

Gut. 2016 Aug; 65(8): 1306–1313. Published online 2015 May 20. doi: 10.1136/gutjnl-2015-309441

PMCID:: PMC4975829

Abstract Article PDF–3.6M

Select item 485040616.

Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index

Danfeng Lan, Junkun Niu, Jiarong Miao, Xiangqian Dong, Hong Wang, Gang Yang, Kunhua Wang, Yinglei Miao

Sci Rep. 2016; 6: 25034. Published online 2016 Apr 29. doi: 10.1038/srep25034

PMCID:: PMC4850406

Abstract Article PDF–570K

Select item 471783417.

Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis

Jieru E. Lin, Francheska Colon-Gonzalez, Erik Blomain, Gilbert W. Kim, Amanda Aing, Brian Stoecker, Justin Rock, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Michal Tomczak, Richard S. Blumberg, Scott A. Waldman

Cancer Res. Author manuscript; available in PMC 2017 Jan 15.

Published in final edited form as: Cancer Res. 2016 Jan 15; 76(2): 339–346. doi: 10.1158/0008-5472.CAN-15-1467-T

PMCID:: PMC4717834

Abstract Article PDF–873K

Select item 446351118.

Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene

Amanda Smith, Dennis E Bulman, Claire Goldsmith, Eric Bareke, FORGE Canada Consortium, Jacek Majewski, Kym M Boycott, Sarah M Nikkel

Eur J Hum Genet. 2015 Jul; 23(7): 990–992. Published online 2014 Nov 5. doi: 10.1038/ejhg.2014.236

PMCID:: PMC4463511

Abstract Article PDF–439K

Select item 387957919.

Intestinal Cell Proliferation and Senescence Are Regulated by Receptor Guanylyl Cyclase C and p21

Nirmalya Basu, Sayanti Saha, Imran Khan, Subbaraya G. Ramachandra, Sandhya S. Visweswariah

J Biol Chem. 2014 Jan 3; 289(1): 581–593. Published online 2013 Nov 11. doi: 10.1074/jbc.M113.511311

PMCID:: PMC3879579

Abstract Article PDF–2.0M

Select item 383863220.

Intestinal GUCY2C Prevents TGF-β Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer

Ahmara V. Gibbons, Jieru E. Lin, Gilbert W. Kim, Glen P. Marszalowicz, Peng Li, Brian A. Stoecker, Erik S. Blomain, Satish Rattan, Adam E. Snook, Stephanie Schulz, Scott A. Waldman

Cancer Res. Author manuscript; available in PMC 2014 Nov 15.

Published in final edited form as: Cancer Res. 2013 Nov 15; 73(22): 10.1158/0008-5472.CAN-13-0887. Published online 2013 Oct 1. doi: 10.1158/0008-5472.CAN-13-0887

PMCID:: PMC3838632

Abstract Article PDF–4.1M

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