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Select item 111597481.

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel‐induced leukopenia

Kazuma Kiyotani, Taisei Mushiroda, Michiaki Kubo, Hitoshi Zembutsu, Yuichi Sugiyama, Yusuke Nakamura

Cancer Sci. 2008 May; 99(5): 967–972. Published online 2008 Feb 20. doi: 10.1111/j.1349-7006.2008.00765.x

PMCID:: PMC11159748

Abstract Article PDF–101K

Select item 111150812.

Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2

Yong Zhang, Guoyu Yu, Yanjie Wang, Yang Xiang, Qian Gao, Ping Jiang, Jie Zhang, Wenhui Lee, Yun Zhang

Cell Mol Life Sci. 2011 Nov; 68(22): 3771–3780. Published online 2011 Apr 3. doi: 10.1007/s00018-011-0678-6

PMCID:: PMC11115081

Abstract Article PDF–2.2M

Select item 110228993.

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

Moumita Dutta, Joe Jongpyo Lim, Julia Yue Cui

Drug Metab Dispos. 2022 Apr; 50(4): 478–491. Published online 2022 Apr. doi: 10.1124/dmd.121.000415

PMCID:: PMC11022899

Abstract Article PDF–424K

Select item 101679194.

St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism

Tingting Yan, Yuhong Luo, Yangliu Xia, Keisuke Hamada, Qiong Wang, Nana Yan, Kristopher W. Krausz, Jerrold M. Ward, Haiping Hao, Ping Wang, Frank J. Gonzalez

FASEB J. Author manuscript; available in PMC 2023 May 9.

Published in final edited form as: FASEB J. 2021 Nov; 35(11): e21968. doi: 10.1096/fj.202001098R

PMCID:: PMC10167919

Abstract Article PDF–2.7M

Select item 95700575.

Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients

Hironobu Yagishita, Hideaki Kagaya, Mitsuru Saito, Kazuyuki Numakura, Ryohei Yamamoto, Ryuichiro Sagehashi, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura

Int J Mol Sci. 2022 Oct; 23(19): 11742. Published online 2022 Oct 3. doi: 10.3390/ijms231911742

PMCID:: PMC9570057

Abstract Article PDF–510K

Select item 93383136.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 92235607.

Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age

Wei Li, Ehab Osman, Claes Forssell, Xi-Ming Yuan

Int J Mol Sci. 2022 Jun; 23(12): 6363. Published online 2022 Jun 7. doi: 10.3390/ijms23126363

PMCID:: PMC9223560

Abstract Article PDF–1.2M

Select item 89895238.

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen

Nucleic Acids Res. 2022 Apr 8; 50(6): 3254–3275. Published online 2022 Feb 25. doi: 10.1093/nar/gkac133

PMCID:: PMC8989523

Abstract Article PDF–2.8M

Select item 89658889.

Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3

Xiaxia Niu, Hongmei Cui, Xinsheng Gu, Ting Wu, Min Sun, Changlong Zhou, Mei Ma

Front Oncol. 2022; 12: 837980. Published online 2022 Mar 16. doi: 10.3389/fonc.2022.837980

PMCID:: PMC8965888

Abstract Article PDF–5.4M

Select item 891851510.

The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance G_q/G_i Signaling

Qiu-Yan Xu, Yong-Jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang

Front Immunol. 2022; 13: 818151. Published online 2022 Feb 28. doi: 10.3389/fimmu.2022.818151

PMCID:: PMC8918515

Abstract Article PDF–3.7M

Select item 883390611.

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia

Mikko Karpale, Janne Hukkanen, Jukka Hakkola

Cells. 2022 Feb; 11(3): 313. Published online 2022 Jan 18. doi: 10.3390/cells11030313

PMCID:: PMC8833906

Abstract Article PDF–892K

Select item 877382112.

Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis

Mengyao Qin, Yu Xin, Yong Bian, Xuan Yang, Tao Xi, Jing Xiong

Cells. 2022 Jan; 11(2): 264. Published online 2022 Jan 13. doi: 10.3390/cells11020264

PMCID:: PMC8773821

Abstract Article PDF–3.2M

Select item 870037713.

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari

Cells. 2021 Dec; 10(12): 3550. Published online 2021 Dec 16. doi: 10.3390/cells10123550

PMCID:: PMC8700377

Abstract Article PDF–2.5M

Select item 870017814.

Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation

Julian Friebel, Eileen Moritz, Marco Witkowski, Kai Jakobs, Elisabeth Strässler, Andrea Dörner, Daniel Steffens, Marianna Puccini, Stella Lammel, Rainer Glauben, Franziska Nowak, Nicolle Kränkel, Arash Haghikia, Verena Moos, Heinz-Peter Schutheiss, Stephan B. Felix, Ulf Landmesser, Bernhard H. Rauch, Ursula Rauch

Cells. 2021 Dec; 10(12): 3517. Published online 2021 Dec 13. doi: 10.3390/cells10123517

PMCID:: PMC8700178

Abstract Article PDF–5.8M

Select item 839456215.

Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment

Aikaterini Skandalaki, Panagiotis Sarantis, Stamatios Theocharis

Biomolecules. 2021 Aug; 11(8): 1142. Published online 2021 Aug 2. doi: 10.3390/biom11081142

PMCID:: PMC8394562

Abstract Article PDF–1.4M

Select item 825776316.

High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Venkateswara R. Gogulamudi, Danielle Y. Arita, Camille R. T. Bourgeois, Justine Jorgensen, Jing He, William C. Wimley, Ryosuke Satou, Alexis A. Gonzalez, Minolfa C. Prieto

Sci Rep. 2021; 11: 13815. Published online 2021 Jul 5. doi: 10.1038/s41598-021-93296-4

PMCID:: PMC8257763

Abstract Article PDF–3.3M

Select item 820349817.

B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation

Cinzia Giagulli, Francesca Caccuri, Simone Zorzan, Antonella Bugatti, Alberto Zani, Federica Filippini, Ekta Manocha, Pasqualina D’Ursi, Alessandro Orro, Riccardo Dolcetti, Arnaldo Caruso

Cancer Gene Ther. 2021; 28(6): 649–666. Published online 2020 Oct 22. doi: 10.1038/s41417-020-00246-9

PMCID:: PMC8203498

Abstract Article PDF–2.3M

Select item 800904818.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 794041119.

Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis

Hanze Guo, Yan Chi, Naiyu Chi

Sci Rep. 2021; 11: 5428. Published online 2021 Mar 8. doi: 10.1038/s41598-021-83742-8

PMCID:: PMC7940411

Abstract Article PDF–2.0M

Select item 781712020.

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

Vanessa Delfosse, Tiphaine Huet, Deborah Harrus, Meritxell Granell, Maxime Bourguet, Caroline Gardia-Parège, Barbara Chiavarina, Marina Grimaldi, Sébastien Le Mével, Pauline Blanc, David Huang, Jakub Gruszczyk, Barbara Demeneix, Sarah Cianférani, Jean-Baptiste Fini, Patrick Balaguer, William Bourguet

Proc Natl Acad Sci U S A. 2021 Jan 5; 118(1): e2020551118. Published online 2020 Dec 28. doi: 10.1073/pnas.2020551118