PMC Links for GEO Profiles (Select 122083402) - PMC

Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian

Cell Death Dis. 2022 Sep; 13(9): 820. Published online 2022 Sep 24. doi: 10.1038/s41419-022-05262-1

PMCID:: PMC9509360

Abstract Article PDF–4.2M

Select item 91359434.

DNA damage-induced degradation of Sp1 promotes cellular senescence

Michelle L. Swift, Christian Sell, Jane Azizkhan-Clifford

GeroScience. 2022 Apr; 44(2): 683–698. Published online 2021 Sep 22. doi: 10.1007/s11357-021-00456-5

PMCID:: PMC9135943

Abstract Article PDF–3.5M

Select item 91052355.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 87690726.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 87600777.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6

PMCID:: PMC8760077

Abstract Article PDF–12M

Select item 86331188.

RNF4 Regulates the BLM Helicase in Recovery From Replication Fork Collapse

Nathan Ellis, Jianmei Zhu, Mary K Yagle, Wei-Chih Yang, Jing Huang, Alexander Kwako, Michael M. Seidman, Michael J. Matunis

Front Genet. 2021; 12: 753535. Published online 2021 Nov 12. doi: 10.3389/fgene.2021.753535

PMCID:: PMC8633118

Abstract Article PDF–2.4M

Select item 84868789.

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Thery, Lia Martina, Caroline Asselman, Yifeng Zhang, Madeleine Vessely, Heidi Repo, Koen Sedeyn, George D. Moschonas, Clara Bredow, Qi Wen Teo, Jingshu Zhang, Kevin Leandro, Denzel Eggermont, Delphine De Sutter, Katie Boucher, Tino Hochepied, Nele Festjens, Nico Callewaert, Xavier Saelens, Bart Dermaut, Klaus-Peter Knobeloch, Antje Beling, Sumana Sanyal, Lilliana Radoshevich, Sven Eyckerman, Francis Impens

Nat Commun. 2021; 12: 5772. Published online 2021 Oct 1. doi: 10.1038/s41467-021-26061-w

PMCID:: PMC8486878

Abstract Article PDF–7.6M

Select item 832207710.

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber

Nat Commun. 2021; 12: 4608. Published online 2021 Jul 29. doi: 10.1038/s41467-021-24669-6

PMCID:: PMC8322077

Abstract Article PDF–2.7M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808103312.

Regulation of eIF2α by RNF4 promotes melanoma tumorigenesis and therapy resistance

Emily Avitan-Hersh, Yongmei Feng, Avital Oknin Vaisman, Yamen Abu Ahmed, Yaniv Zohar, Tongwu Zhang, Joo Sang Lee, Ikrame Lazar, Saeed Sheikh Khalil, Yulia Feiler, Harriet Kluger, Chaim Kahana, Kevin Brown, Eytan Ruppin, Ze’ev A. Ronai, Amir Orian

J Invest Dermatol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: J Invest Dermatol. 2020 Dec; 140(12): 2466–2477. Published online 2020 Apr 29. doi: 10.1016/j.jid.2020.04.008

PMCID:: PMC8081033

Abstract Article PDF–1.8M

Select item 800010013.

ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP

Jinhua Han, Li Wan, Guixing Jiang, Liping Cao, Feiyu Xia, Tian Tian, Xiaomei Zhu, Mingjie Wu, Michael S. Y. Huen, Yi Wang, Ting Liu, Jun Huang

Proc Natl Acad Sci U S A. 2021 Mar 23; 118(12): e2022600118. Published online 2021 Mar 15. doi: 10.1073/pnas.2022600118

PMCID:: PMC8000100

Abstract Article PDF–2.1M

Select item 767375414.

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

Yilun Sun, Lisa M. Miller Jenkins, Yijun P. Su, Karin C. Nitiss, John L. Nitiss, Yves Pommier

Sci Adv. 2020 Nov; 6(46): eaba6290. Published online 2020 Nov 13. doi: 10.1126/sciadv.aba6290

PMCID:: PMC7673754

Abstract Article PDF–10M

Select item 752033415.

Knockdown of endogenous RNF4 exacerbates ischaemia‐induced cardiomyocyte apoptosis in mice

Fang Qiu, Yanna Han, Xiaoqi Shao, Petro Paulo, Wenyue Li, Mengying Zhu, Nannan Tang, Shuaili Guo, Yibing Chen, Han Wu, Dan Zhao, Yu Liu, Wenfeng Chu

J Cell Mol Med. 2020 Sep; 24(17): 9545–9559. Published online 2020 Jul 28. doi: 10.1111/jcmm.15363

PMCID:: PMC7520334

Abstract Article PDF–2.4M

Select item 742272116.

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Carl C. Ward, Jordan I. Kleinman, Scott M. Brittain, Patrick S. Lee, Clive Yik Sham Chung, Kenneth Kim, Yana Petri, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Daniel K. Nomura

ACS Chem Biol. Author manuscript; available in PMC 2020 Nov 15.

Published in final edited form as: ACS Chem Biol. 2019 Nov 15; 14(11): 2430–2440. Published online 2019 May 13. doi: 10.1021/acschembio.8b01083

PMCID:: PMC7422721

Abstract Article PDF–1.7M

Select item 739350517.

Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

Paul Murphy, Yingqi Xu, Sarah L. Rouse, Ellis G. Jaffray, Anna Plechanovová, Steve J. Matthews, J. Carlos Penedo, Ronald T. Hay

Nat Commun. 2020; 11: 3807. Published online 2020 Jul 30. doi: 10.1038/s41467-020-17647-x

PMCID:: PMC7393505

Abstract Article PDF–3.1M

Select item 732206718.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 730709019.

Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection

Behdokht Jan Fada, Elie Kaadi, Subodh Kumar Samrat, Yi Zheng, Haidong Gu

J Virol. 2020 Jun; 94(12): e00470-20. Prepublished online 2020 Apr 15. Published online 2020 Jun 1. doi: 10.1128/JVI.00470-20

PMCID:: PMC7307090

Abstract Article PDF–2.2M

Select item 716998320.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

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