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Select item 109841011.

PML‐mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions

Yunpeng Chu, Zishan Jiang, Zheng Gong, Xiaocao Ji, Mengting Zhu, Qianwen Shang, Pixia Gong, Lijuan Cao, Yongjing Chen, Peishan Li, Changshun Shao, Yufang Shi

Cell Prolif. 2024 Apr; 57(4): e13566. Published online 2023 Oct 20. doi: 10.1111/cpr.13566

PMCID:: PMC10984101

Abstract Article PDF–4.1M

Select item 106390712.

PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer

Cristina Fracassi, Martina Ugge', Mohamed Abdelhalim, Ettore Zapparoli, Matilde Simoni, Daniela Magliulo, Davide Mazza, Dejan Lazarevic, Marco J Morelli, Philippe Collas, Rosa Bernardi

Nucleic Acids Res. 2023 Nov 10; 51(20): 11024–11039. Published online 2023 Oct 12. doi: 10.1093/nar/gkad819

PMCID:: PMC10639071

Abstract Article PDF–2.0M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105529024.

Promyelocytic leukemia protein regulates angiogenesis and epithelial–mesenchymal transition to limit metastasis in MDA‐MB‐231 breast cancer cells

Amalia P. Vogiatzoglou, Syrago Spanou, Nikoleta Sachini, Elias Drakos, Christoforos Nikolaou, Takis Makatounakis, Androniki Kretsovali, Joseph Papamatheakis

Mol Oncol. 2023 Oct; 17(10): 2090–2108. Published online 2023 Sep 4. doi: 10.1002/1878-0261.13501

PMCID:: PMC10552902

Abstract Article PDF–11M

Select item 102431165.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt

J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706

PMCID:: PMC10243116

Abstract Article PDF–13M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101231247.

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Sabateeshan Mathavarajah, Kathleen L Vergunst, Elias B Habib, Shelby K Williams, Raymond He, Maria Maliougina, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J Roger, David N Langelaan, Graham Dellaire

Nucleic Acids Res. 2023 Apr 24; 51(7): 3185–3204. Published online 2023 Mar 13. doi: 10.1093/nar/gkad152

PMCID:: PMC10123124

Abstract Article PDF–6.1M

Select item 100058988.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 99504479.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 991141010.

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbála Mifsud, Cameron S. Osborne

Nat Commun. 2023; 14: 724. Published online 2023 Feb 9. doi: 10.1038/s41467-023-36262-0

PMCID:: PMC9911410

Abstract Article PDF–3.7M

Select item 991000911.

Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation

Di Huang, Dan Zhao, Ming Li, Si-Yu Chang, Ya-Dong Xue, Ning Xu, Si-Jia Li, Nan-Nan Tang, Li-Ling Gong, Yi-Ning Liu, Hang Yu, Qing-Sui Li, Peng-Yu Li, Jia-Li Liu, Hai-Xin Chen, Ming-Bin Liu, Wan-Yu Zhang, Xing-Miao Zhao, Xian-Zhi Lang, Zhen-Dong Li, Yu Liu, Zhi-Yong Ma, Jia-Min Li, Ning Wang, Hai Tian, Ben-Zhi Cai

Int J Biol Sci. 2023; 19(3): 994–1006. Published online 2023 Jan 22. doi: 10.7150/ijbs.76214

PMCID:: PMC9910009

Abstract Article PDF–5.7M

Select item 976969812.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 971308013.

PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment

Sonia Missiroli, Mariasole Perrone, Roberta Gafà, Francesco Nicoli, Massimo Bonora, Giampaolo Morciano, Caterina Boncompagni, Saverio Marchi, Magdalena Lebiedzinska-Arciszewska, Bianca Vezzani, Giovanni Lanza, Franz Kricek, Alessandro Borghi, Francesco Fiorica, Keisuke Ito, Mariusz R. Wieckowski, Francesco Di Virgilio, Luigi Abelli, Paolo Pinton, Carlotta Giorgi

Cell Death Differ. 2023 Feb; 30(2): 429–441. Published online 2022 Nov 30. doi: 10.1038/s41418-022-01095-9

PMCID:: PMC9713080

Abstract Article PDF–4.6M

Select item 970808614.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 956966115.

Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells

Sven Seitz, Anna Theresa Heusel, Thomas Stamminger, Myriam Scherer

Int J Mol Sci. 2022 Oct; 23(19): 11931. Published online 2022 Oct 8. doi: 10.3390/ijms231911931

PMCID:: PMC9569661

Abstract Article PDF–3.3M

Select item 949123216.

The B-box1 domain of PML mediates SUMO E2-E3 complex formation through an atypical interaction with UBC9

Thomas Bregnard, Affrin Ahmed, Irina V. Semenova, Sandra K. Weller, Irina Bezsonova

Biophys Chem. Author manuscript; available in PMC 2022 Sep 21.

Published in final edited form as: Biophys Chem. 2022 Aug; 287: 106827. Published online 2022 May 18. doi: 10.1016/j.bpc.2022.106827

PMCID:: PMC9491232

Abstract Article PDF–928K

Select item 948193317.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 939206318.

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai, Xiaoyan Huang, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson K. C. Chiu, Weiye Zhong, Gang Li

Nat Commun. 2022; 13: 4906. Published online 2022 Aug 20. doi: 10.1038/s41467-022-32689-z

PMCID:: PMC9392063

Abstract Article PDF–2.0M

Select item 927928519.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973620.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

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