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Select item 112127311.

TGR5 deficiency in excitatory neurons ameliorates Alzheimer’s pathology by regulating APP processing

Chenli Li, Liangjie Wang, Wenting Xie, Erqu Chen, Yanbing Chen, Huifang Li, Dan Can, Aiyu Lei, Yue Wang, Jie Zhang

Sci Adv. 2024 Jun 28; 10(26): eado1855. Published online 2024 Jun 28. doi: 10.1126/sciadv.ado1855

PMCID:: PMC11212731

Abstract Article PDF–8.5M

Select item 109494242.

The function of the gut microbiota–bile acid–TGR5 axis in diarrhea-predominant irritable bowel syndrome

Kai Zhan, Haomeng Wu, Yongyin Xu, Kehan Rao, Huan Zheng, Shumin Qin, Yuanming Yang, Rui Jia, Weihuan Chen, Shaogang Huang

mSystems. 2024 Mar; 9(3): e01299-23. Published online 2024 Feb 8. doi: 10.1128/msystems.01299-23

PMCID:: PMC10949424

Abstract Article PDF–3.1M

Select item 93039953.

Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity

Lijuan Ma, Fan Yang, Xiang Wu, Chunyou Mao, Lulu Guo, Tianshu Miao, Shao-Kun Zang, Xiaoyu Jiang, Dan-Dan Shen, Tianhui Wei, Hengxing Zhou, Qin Wei, Shiyang Li, Qiang Shu, Shiqing Feng, Changtao Jiang, Bo Chu, Lutao Du, Jin-Peng Sun, Xiao Yu, Yan Zhang, Pengju Zhang

Proc Natl Acad Sci U S A. 2022 Jul 19; 119(29): e2117054119. Published online 2022 Jul 15. doi: 10.1073/pnas.2117054119

PMCID:: PMC9303995

Abstract Article PDF–2.9M

Select item 92950634.

Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling

Jianping Hu, Yiting Zhang, Shenglan Yi, Chaokui Wang, Xinyue Huang, Su Pan, Jinglu Yang, Gangxiang Yuan, Sisi Tan, Hong Li

Int J Biol Sci. 2022; 18(11): 4545–4559. Published online 2022 Jul 11. doi: 10.7150/ijbs.71287

PMCID:: PMC9295063

Abstract Article PDF–2.9M

Select item 90196335.

GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease

Jahirul Islam, Jung-Ah Cho, Ju-yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C. Kim, Kyung-Hwa Lee, Seung-Yong Seong

Front Immunol. 2022; 13: 766919. Published online 2022 Apr 6. doi: 10.3389/fimmu.2022.766919

PMCID:: PMC9019633

Abstract Article PDF–20M

Select item 89981276.

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

Michele Biagioli, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Rachele Bellini, Martina Bordoni, Eleonora Distrutti, Bruno Catalanotti, Angela Zampella, Luigina Graziosi, Annibale Donini, Stefano Fiorucci

Cells. 2022 Apr; 11(7): 1187. Published online 2022 Apr 1. doi: 10.3390/cells11071187

PMCID:: PMC8998127

Abstract Article PDF–5.1M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80821158.

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction

Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller

Cell Mol Gastroenterol Hepatol. 2021; 12(1): 25–40. Published online 2021 Feb 2. doi: 10.1016/j.jcmgh.2021.01.011

PMCID:: PMC8082115

Abstract Article PDF–3.4M

Select item 79378189.

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Yong Shi, Wantong Su, Lei Zhang, Chengyu Shi, Jinren Zhou, Peng Wang, Hao Wang, Xiaoli Shi, Song Wei, Qi Wang, Johan Auwerx, Kristina Schoonjans, Yue Yu, Rui Pan, Haoming Zhou, Ling Lu

Front Immunol. 2020; 11: 609060. Published online 2021 Feb 22. doi: 10.3389/fimmu.2020.609060

PMCID:: PMC7937818

Abstract Article PDF–7.0M

Select item 789187010.

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects

Snehal N. Chaudhari, David A. Harris, Hassan Aliakbarian, James N. Luo, Matthew T. Henke, Renuka Subramaniam, Ashley H. Vernon, Ali Tavakkoli, Eric G. Sheu, A. Sloan Devlin

Nat Chem Biol. Author manuscript; available in PMC 2021 Feb 18.

Published in final edited form as: Nat Chem Biol. 2021 Jan; 17(1): 20–29. Published online 2020 Aug 3. doi: 10.1038/s41589-020-0604-z

PMCID:: PMC7891870

Abstract Article PDF–4.1M

Select item 776034711.

Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome

Piero Portincasa, Agostino Di Ciaula, Gabriella Garruti, Mirco Vacca, Maria De Angelis, David Q.-H. Wang

Nutrients. 2020 Dec; 12(12): 3709. Published online 2020 Nov 30. doi: 10.3390/nu12123709

PMCID:: PMC7760347

Abstract Article PDF–3.1M

Select item 740074212.

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein

Geng Chen, Xiankun Wang, Yunjun Ge, Ling Ma, Qiang Chen, Huihui Liu, Yang Du, Richard D. Ye, Hongli Hu, Ruobing Ren

Signal Transduct Target Ther. 2020; 5: 142. Published online 2020 Aug 3. doi: 10.1038/s41392-020-00262-z

PMCID:: PMC7400742

Article PDF–1.3M

Select item 720697513.

Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex

Jianhua Rao, Chao Yang, Shikun Yang, Hao Lu, Yuanchang Hu, Ling Lu, Feng Cheng, Xuehao Wang

Int Immunol. 2020 May; 32(5): 321–334. Published online 2020 Jan 13. doi: 10.1093/intimm/dxaa002

Correction in:: Int Immunol. 2020 Jan; 34(1): 53.

PMCID:: PMC7206975

Abstract Article PDF–12M

Select item 698109614.

Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway

Junzhi Li, Ruining Cheng, Hong Wan

Biosci Rep. 2020 Jan 31; 40(1): BSR20193482. Published online 2020 Jan 24. doi: 10.1042/BSR20193482

PMCID:: PMC6981096

Abstract Article PDF–1.1M

Select item 694204415.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 679794416.

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II-induced arthritis

Zhe-Yong Li, Jing-Jing Zhou, Chun-Lei Luo, Le-Meng Zhang

Mol Med Rep. 2019 Nov; 20(5): 4540–4550. Published online 2019 Sep 26. doi: 10.3892/mmr.2019.10711

PMCID:: PMC6797944

Abstract Article PDF–852K

Select item 671894917.

GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

Michele Biagioli, Adriana Carino, Chiara Fiorucci, Silvia Marchianò, Cristina Di Giorgio, Rosalinda Roselli, Margherita Magro, Eleonora Distrutti, Oxana Bereshchenko, Paolo Scarpelli, Angela Zampella, Stefano Fiorucci

Cell Mol Gastroenterol Hepatol. 2019; 8(3): 447–473. Published online 2019 Jun 18. doi: 10.1016/j.jcmgh.2019.06.003

PMCID:: PMC6718949

Abstract Article PDF–8.7M

Select item 647052318.

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

Claudia Finamore, Giuliana Baronissi, Silvia Marchianò, Francesco Saverio Di Leva, Adriana Carino, Maria Chiara Monti, Vittorio Limongelli, Angela Zampella, Stefano Fiorucci, Valentina Sepe

Molecules. 2019 Mar; 24(6): 1043. Published online 2019 Mar 16. doi: 10.3390/molecules24061043

PMCID:: PMC6470523

Abstract Article PDF–1.9M

Select item 640340119.

TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells

Kai-Chun Cheng, Wei-Ting Chang, Feng Yu Kuo, Zhih-Cherng Chen, Yingxiao Li, Juei-Tang Cheng

Sci Rep. 2019; 9: 3633. Published online 2019 Mar 6. doi: 10.1038/s41598-019-40002-0

PMCID:: PMC6403401

Abstract Article PDF–3.0M

Select item 638535820.

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

Francesco Saverio Di Leva, Carmen Festa, Adriana Carino, Simona De Marino, Silvia Marchianò, Daniele Di Marino, Claudia Finamore, Maria Chiara Monti, Angela Zampella, Stefano Fiorucci, Vittorio Limongelli

Sci Rep. 2019; 9: 2504. Published online 2019 Feb 21. doi: 10.1038/s41598-019-38840-z

PMCID:: PMC6385358

Abstract Article PDF–1.3M

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