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Select item 108892281.

Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2

Lucía Paniagua-Herranz, Irene Moreno, Cristina Nieto-Jiménez, Esther Garcia-Lorenzo, Cristina Díaz-Tejeiro, Adrián Sanvicente, Bernard Doger, Manuel Pedregal, Jorge Ramón, Jorge Bartolomé, Arancha Manzano, Balázs Gyorffy, Álvaro Gutierrez-Uzquiza, Pedro Pérez Segura, Emiliano Calvo, Víctor Moreno, Alberto Ocana

Int J Mol Sci. 2024 Feb; 25(4): 2222. Published online 2024 Feb 13. doi: 10.3390/ijms25042222

PMCID:: PMC10889228

Abstract Article PDF–3.4M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 68249323.

Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer

Melanie A. Krook, Hannah Barker, Hui-Zi Chen, Julie W. Reeser, Michele R. Wing, Dorrelyn Martin, Amy M. Smith, Thuy Dao, Russell Bonneville, Eric Samorodnitsky, Jharna Miya, Aharon G. Freud, J. Paul Monk, Steven K. Clinton, Sameek Roychowdhury

Prostate Cancer Prostatic Dis. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Prostate Cancer Prostatic Dis. 2019 Dec; 22(4): 624–632. Published online 2019 May 1. doi: 10.1038/s41391-019-0145-2

PMCID:: PMC6824932

Abstract Article PDF–1.3M

Select item 55316114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 47053805.

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

Shihui Guo, Wolfgang Skala, Viktor Magdolen, Peter Briza, Martin L. Biniossek, Oliver Schilling, Josef Kellermann, Hans Brandstetter, Peter Goettig

J Biol Chem. 2016 Jan 8; 291(2): 593–604. Published online 2015 Nov 18. doi: 10.1074/jbc.M115.691097

PMCID:: PMC4705380

Abstract Article PDF–2.4M

Select item 46172116.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 42563587.

Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity

Wolfgang Skala, Daniel T. Utzschneider, Viktor Magdolen, Mekdes Debela, Shihui Guo, Charles S. Craik, Hans Brandstetter, Peter Goettig

J Biol Chem. 2014 Dec 5; 289(49): 34267–34283. Published online 2014 Oct 17. doi: 10.1074/jbc.M114.598201

PMCID:: PMC4256358

Abstract Article PDF–4.5M

Select item 40767918.

Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia

Katherine J. O’Malley, Kurtis Eisermann, Laura E. Pascal, Anil V. Parwani, Tsuyoshi Majima, Lara Graham, Katherine Hrebinko, Marie Acquafondata, Nicolas A. Stewart, Joel B. Nelson, Naoki Yoshimura, Zhou Wang

Prostate. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Prostate. 2014 Jun; 74(8): 892–900. Published online 2014 Apr 7. doi: 10.1002/pros.22807

PMCID:: PMC4076791

Abstract Article PDF–2.9M

Select item 40734949.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 398231910.

Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer

Manish Kohli, Paul G. Rothberg, Changyong Feng, Edward Messing, Jean Joseph, Sreevidya Sadasiva Rao, Allison Hendershot, Deepak Sahsrabudhe

Cancer Biomark. Author manuscript; available in PMC 2014 Apr 10.

Published in final edited form as: Cancer Biomark. 2010; 7(2): 101–108. doi: 10.3233/CBM-2010-0152

PMCID:: PMC3982319

Abstract Article PDF–513K

Select item 394361411.

Genetic variation in KLK2 and KLK3 is associated with levels of hK2 and PSA in seminal plasma and in serum in young men

Charlotta Sävblom, Christer Halldén, Angel M. Cronin, Torbjörn Säll, Caroline Savage, Emily A. Vertosick, Robert J. Klein, Aleksander Giwercman, Hans Lilja

Clin Chem. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: Clin Chem. 2014 Mar; 60(3): 490–499. Published online 2013 Nov 22. doi: 10.1373/clinchem.2013.211219

PMCID:: PMC3943614

Abstract Article PDF–191K

Select item 378605912.

Predictive Value of Four Kallikrein Markers for Pathologically Insignificant Compared With Aggressive Prostate Cancer in Radical Prostatectomy Specimens: Results From the European Randomized Study of Screening for Prostate Cancer Section Rotterdam

Sigrid Carlsson, Alexandra Maschino, Fritz Schröder, Chris Bangma, Ewout W. Steyerberg, Theo van der Kwast, Geert van Leenders, Andrew Vickers, Hans Lilja, Monique J. Roobol

Eur Urol. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Eur Urol. 2013 Nov; 64(5): 693–699. Published online 2013 May 2. doi: 10.1016/j.eururo.2013.04.040

PMCID:: PMC3786059

Abstract Article PDF–304K

Select item 377350513.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

Select item 373228614.

A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease

Malin Östensson, Caroline Montén, Jonas Bacelis, Audur H. Gudjonsdottir, Svetlana Adamovic, Johan Ek, Henry Ascher, Elisabet Pollak, Henrik Arnell, Lars Browaldh, Daniel Agardh, Jan Wahlström, Staffan Nilsson, Åsa Torinsson-Naluai

PLoS One. 2013; 8(8): e70174. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0070174

PMCID:: PMC3732286

Abstract Article PDF–1.7M

Select item 373200915.

Susceptibility Loci Associated with Prostate Cancer Progression and Mortality

David J. Gallagher, Joseph Vijai, Angel M. Cronin, Jasmine Bhatia, Andrew J. Vickers, Mia M. Gaudet, Samson Fine, Victor Reuter, Howard I. Scher, Christer Halldén, Ana Dutra-Clarke, Robert J. Klein, Peter T. Scardino, James A. Eastham, Hans Lilja, Tomas Kirchhoff, Kenneth Offit

Clin Cancer Res. Author manuscript; available in PMC 2013 Aug 2.

Published in final edited form as: Clin Cancer Res. 2010 May 15; 16(10): 2819–2832. Published online 2010 May 11. doi: 10.1158/1078-0432.CCR-10-0028

PMCID:: PMC3732009

Abstract Article PDF–683K

Select item 361291616.

Genome-wide Association Study Identifies Genetic Determinants of Urine PCA3 Levels in Men

Zhuo Chen, Jielin Sun, Seong-Tae Kim, Jack Groskopf, Junjie Feng, William B Isaacs, Roger S Rittmaster, Lynn D Condreay, Siqun Lilly Zheng, Jianfeng Xu

Neoplasia. 2013 Apr; 15(4): 448–453. doi: 10.1593/neo.122144

PMCID:: PMC3612916

Abstract Article PDF–455K

Select item 355694217.

Genome-wide Association Study Identifies Loci at ATF7IP and KLK2 Associated with Percentage of Circulating Free PSA

Guangfu Jin, Siqun Lilly Zheng, Hans Lilja, Seong-Tae Kim, Sha Tao, Zhengrong Gao, Tracey Young, Fredrik Wiklund, Junjie Feng, William B Isaacs, Roger S Rittmaster, Henrik Gronberg, Lynn D Condreay, Jielin Sun, Jianfeng Xu

Neoplasia. 2013 Jan; 15(1): 95–101. doi: 10.1593/neo.121620

PMCID:: PMC3556942

Abstract Article PDF–717K

Select item 341391918.

Tissue Kallikrein Promotes Cardiac Neovascularization by Enhancing Endothelial Progenitor Cell Functional Capacity

Yuyu Yao, Zulong Sheng, Yefei Li, Fengdi Yan, Cong Fu, Yongjun Li, Genshan Ma, Naifeng Liu, Julie Chao, Lee Chao

Hum Gene Ther. 2012 Aug; 23(8): 859–870. Published online 2012 Mar 22. doi: 10.1089/hum.2011.123

PMCID:: PMC3413919

Abstract Article PDF–1.3M

Select item 319082619.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907