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Select item 112306261.

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

Joshua D Eaton, Jessica Board, Lee Davidson, Chris Estell, Steven West

eLife. 2024; 13: RP92764. Published online 2024 Jul 8. doi: 10.7554/eLife.92764

PMCID:: PMC11230626

Abstract Article PDF–2.3M

Select item 109457072.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 108913443.

Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb

Salla Kyheröinen, Bina Prajapati, Maria Sokolova, Maximilian Schmitz, Tiina Viita, Matthias Geyer, Maria K. Vartiainen

J Biol Chem. 2024 Mar; 300(3): 105698. Published online 2024 Jan 30. doi: 10.1016/j.jbc.2024.105698

PMCID:: PMC10891344

Abstract Article PDF–1.3M

Select item 108736214.

RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization

Bo Dong, Xinzhao Wang, Xiang Song, Jianlin Wang, Xia Liu, Zhiyong Yu, Yongkun Zhou, Jiong Deng, Yadi Wu

Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7): e2307150121. Published online 2024 Feb 5. doi: 10.1073/pnas.2307150121

PMCID:: PMC10873621

Abstract Article PDF–11M

Select item 107689775.

CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity

Isha Bhutada, Fatema Khambati, Shi-Yuan Cheng, Deanna M Tiek, Derek Duckett, Harshani Lawrence, Michael A Vogelbaum, Qianxing Mo, Srikumar P Chellappan, Jaya Padmanabhan

Neuro Oncol. 2024 Jan; 26(1): 70–84. Published online 2023 Aug 8. doi: 10.1093/neuonc/noad143

PMCID:: PMC10768977

Abstract Article PDF–28M

Select item 106201256.

Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer

Dexter Kai Hao Thng, Lissa Hooi, Clarissa Chin Min Toh, Jhin Jieh Lim, Deepa Rajagopalan, Imran Qamar Charles Syariff, Zher Min Tan, Masturah Bte Mohd Abdul Rashid, Lei Zhou, Alfred Wei Chieh Kow, Glenn Kunnath Bonney, Brian Kim Poh Goh, Juinn Huar Kam, Sudhakar Jha, Yock Young Dan, Pierce Kah Hoe Chow, Tan Boon Toh, Edward Kai‐Hua Chow

Mol Oncol. 2023 Nov; 17(11): 2275–2294. Published online 2023 Mar 29. doi: 10.1002/1878-0261.13417

PMCID:: PMC10620125

Abstract Article PDF–2.9M

Select item 105129287.

Degradation of CDK9 by Ubiquitin E3 Ligase STUB1 Regulates P-TEFb Level and Its Functions for Global Target Gene Expression within Mammalian Cells

Subham Basu, Arijit Nandy, Avik Ghosh, Dheerendra Pratap Mall, Debabrata Biswas

Mol Cell Biol. 2023; 43(9): 451–471. Published online 2023 Aug 11. doi: 10.1080/10985549.2023.2239694

PMCID:: PMC10512928

Abstract Article PDF–1.5M

Select item 104805358.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1012499610.

The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11

Daniela Boehm, Victor Lam, Martina Schnolzer, Melanie Ott

Cell Rep. Author manuscript; available in PMC 2023 Apr 24.

Published in final edited form as: Cell Rep. 2023 Mar 28; 42(3): 112234. Published online 2023 Mar 9. doi: 10.1016/j.celrep.2023.112234

PMCID:: PMC10124996

Abstract Article PDF–2.3M

Select item 1007290611.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1002268612.

Myosin-X recruits lamellipodin to filopodia tips

Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L. B. Grönloh, Neil J. Ball, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet

J Cell Sci. 2023 Mar 1; 136(5): jcs260574. Published online 2023 Mar 2. doi: 10.1242/jcs.260574

PMCID:: PMC10022686

Abstract Article

Select item 995044713.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 987099214.

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation

Riley M. Horvath, Matthew Dahabieh, Tom Malcolm, Ivan Sadowski

Commun Biol. 2023; 6: 86. Published online 2023 Jan 23. doi: 10.1038/s42003-023-04484-z

PMCID:: PMC9870992

Abstract Article PDF–1.7M

Select item 976969815.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 959030416.

Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions

Subham Basu, Arijit Nandy, Mahesh K. Barad, Sujay Pal, Debabrata Biswas

Mol Cell Biol. 2022 Oct; 42(10): e00151-22. Published online 2022 Aug 29. doi: 10.1128/mcb.00151-22

PMCID:: PMC9590304

Abstract Article PDF–3.2M

Select item 953129517.

SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription

Prajakta Tathe, K V S Rammohan Chowdary, Krushna Chandra Murmu, Punit Prasad, Subbareddy Maddika

EMBO J. 2022 Oct; 41(19): e109720. Published online 2022 Aug 8. doi: 10.15252/embj.2021109720

PMCID:: PMC9531295

Abstract Article PDF–2.7M

Select item 950735718.

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer

Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Qinong Ye

Adv Sci (Weinh) 2022 Sep; 9(27): 2200705. Published online 2022 Jul 27. doi: 10.1002/advs.202200705

PMCID:: PMC9507357

Abstract Article PDF–4.1M

Select item 935618619.

Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease

Omer S. Omer, Arnulf Hertweck, Luke B. Roberts, Jonathan W. Lo, Jennie N. Clough, Ian Jackson, Eirini D. Pantazi, Peter M. Irving, Tom T. MacDonald, Polychronis Pavlidis, Richard G. Jenner, Graham M. Lord

Cell Mol Gastroenterol Hepatol. 2022; 14(3): 625–641. Published online 2022 Jun 1. doi: 10.1016/j.jcmgh.2022.05.011

PMCID:: PMC9356186

Abstract Article PDF–3.5M

Select item 933831320.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4