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Select item 107609611.

Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models

Guo Ge, Peng Zhang, Pinpin Sui, Shi Chen, Hui Yang, Ying Guo, Ivan P. Rubalcava, Asra Noor, Caroline R. Delma, Joel Agosto-Peña, Hui Geng, Edward A. Medina, Ying Liang, Stephen D. Nimer, Ruben Mesa, Omar Abdel-Wahab, Mingjiang Xu, Feng-Chun Yang

J Clin Invest. 2024 Jan 2; 134(1): e163964. Published online 2024 Jan 2. doi: 10.1172/JCI163964

PMCID:: PMC10760961

Abstract Article PDF–12M

Select item 104119022.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1

Jonathan F. Thomas, Marco Igor Valencia-Sánchez, Simone Tamburri, Susan L. Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan Gretarsson, Jonathan M. Burg, Allison R. Hickman, Lu Sun, Saarang Gopinath, Hailey F. Taylor, Zu-Wen Sun, Ryan J. Ezell, Anup Vaidya, Matthew J. Meiners, Marcus A. Cheek, William J. Rice, Vladimir Svetlov, Evgeny Nudler, Chao Lu, Michael-Christopher Keogh, Diego Pasini, Karim-Jean Armache

Sci Adv. 2023 Aug; 9(32): eadg9832. Published online 2023 Aug 9. doi: 10.1126/sciadv.adg9832

PMCID:: PMC10411902

Abstract Article PDF–1.6M

Select item 102843513.

Genomic characteristics and prognostic significance of co-mutated ASXL1/SRSF2 acute myeloid leukemia

Daniel R. Richardson, David M. Swoboda, Dominic T. Moore, Steven M. Johnson, Onyee Chan, Jonathan Galeotti, Sonia Esparza, Mohammad O. Hussaini, Hendrick Van Deventer, Matthew C. Foster, Catherine C. Coombs, Nathan D. Montgomery, David A. Sallman, Joshua F. Zeidner

Am J Hematol. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Am J Hematol. 2021 Apr 1; 96(4): 462–470. Published online 2021 Feb 15. doi: 10.1002/ajh.26110

PMCID:: PMC10284351

Abstract Article PDF–957K

Select item 101193774.

Non-driver mutations landscape in different stages of primary myelofibrosis determined ASXL1 mutations play a critical role in disease progression

Xin Yan, Zefeng Xu, Peihong Zhang, Qi Sun, Yujiao Jia, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Zhanqi Li, Jinqin Liu, Zhen Song, Qingyan Gao, Meng Jiao, Jingye Gong, Huijun Wang, Bing Li, Zhijian Xiao

Blood Cancer J. 2023 Dec; 13(1): 56. Published online 2023 Apr 20. doi: 10.1038/s41408-023-00829-3

PMCID:: PMC10119377

Article PDF–1.0M

Select item 99801325.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

Jonathan F. Thomas, Marco Igor Valencia-Sánchez, Simone Tamburri, Susan L. Gloor, Samantha Rustichelli, Victoria Godínez-López, Pablo De Ioannes, Rachel Lee, Stephen Abini-Agbomson, Kristjan Gretarsson, Jonathan M. Burg, Allison R. Hickman, Lu Sun, Saarang Gopinath, Hailey Taylor, Matthew J. Meiners, Marcus A. Cheek, William Rice, Evgeny Nudler, Chao Lu, Michael-Christopher Keogh, Diego Pasini, Karim-Jean Armache

Version 1. bioRxiv. Preprint. 2023 Feb 23. doi: 10.1101/2023.02.23.529554

Published in:: Sci Adv. 2023 Aug; 9(32): eadg9832.

PMCID:: PMC9980132

Abstract Article PDF–30M

Select item 96168676.

Prognostic impact of ASXL1 mutations in chronic phase chronic myeloid leukemia

Aram Bidikian, Hagop Kantarjian, Elias Jabbour, Nicholas J. Short, Keyur Patel, Farhad Ravandi, Koji Sasaki, Ghayas C. Issa

Blood Cancer J. 2022 Oct; 12(10): 144. Published online 2022 Oct 28. doi: 10.1038/s41408-022-00742-1

PMCID:: PMC9616867

Abstract Article PDF–818K

Select item 95239977.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 93609558.

High Frequency of ASXL1 and IDH Mutations in Young Acute Myeloid Leukemia Egyptian Patients

Yasser H El Nahass, Heba A Nader, Salwa Sabet, Hend A Nooh, Heba Bassiony, Mahmoud Kamel, Mohamed A Samra, Hossam K Mahmoud, Wafaa H El Metnawy, Fatma A El Refaey

Asian Pac J Cancer Prev. 2022 Mar; 23(3): 977–984. doi: 10.31557/APJCP.2022.23.3.977

PMCID:: PMC9360955

Abstract Article PDF–412K

Select item 92587029.

Evaluating the frequency, prognosis and survival of RUNX1 and ASXL1 mutations in patients with acute myeloid leukaemia in northeastern Iran

Mohammad Parsa‐kondelaji, Hossein Ayatollahi, Mehrdad Rostami, Maryam Sheikhi, Faezeh Barzegar, Monnavar Afzalaghaee, Elmira Moradi, Mohammad Hadi Sadeghian, Amir Abbas Momtazi‐Borojeni

J Cell Mol Med. 2022 Jul; 26(13): 3797–3801. Published online 2022 Jun 12. doi: 10.1111/jcmm.17424

PMCID:: PMC9258702

Abstract Article PDF–430K

Select item 909242210.

ASXL1 mutations are prognostically significant in PMF, but not MF following essential thrombocythemia or polycythemia vera

Paola Guglielmelli, Giacomo Coltro, Francesco Mannelli, Giada Rotunno, Giuseppe G. Loscocco, Carmela Mannarelli, Chiara Maccari, Chiara Paoli, Simone Romagnoli, Niccolò Bartalucci, Alessandro M. Vannucchi

Blood Adv. 2022 May 10; 6(9): 2927–2931. Published online 2022 May 9. doi: 10.1182/bloodadvances.2021006350

PMCID:: PMC9092422

Article PDF–839K

Select item 894530811.

ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome

Robert R. West, Katherine R. Calvo, Lisa J. Embree, Weixin Wang, Laura M. Tuschong, Thomas R. Bauer, Jr, Desiree Tillo, Justin Lack, Stephenie Droll, Amy P. Hsu, Steven M. Holland, Dennis D. Hickstein

Blood Adv. 2022 Feb 8; 6(3): 793–807. Published online 2022 Jan 31. doi: 10.1182/bloodadvances.2021005065

PMCID:: PMC8945308

Abstract Article PDF–1.4M

Select item 893104812.

Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia

Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik

Nat Commun. 2022; 13: 1434. Published online 2022 Mar 17. doi: 10.1038/s41467-022-29142-6

PMCID:: PMC8931048

Abstract Article PDF–4.2M

Select item 885468413.

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang

Blood. 2022 Feb 17; 139(7): 1066–1079. doi: 10.1182/blood.2021012519

PMCID:: PMC8854684

Abstract Article

Select item 884251114.

Understanding the phenotypic spectrum of ASXL-related disease: 10 cases and a review of the literature

Vishnu Anand Cuddapah, Holly A. Dubbs, Laura Adang, Steven L. Kugler, Elizabeth M. McCormick, Zarazuela Zolkipli-Cunningham, Xilma R. Ortiz-González, Shana McCormack, Elaine Zackai, Daniel J. Licht, Marni J. Falk, Eric D. Marsh

Am J Med Genet A. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Am J Med Genet A. 2021 Jun; 185(6): 1700–1711. Published online 2021 Mar 10. doi: 10.1002/ajmg.a.62156

PMCID:: PMC8842511

Abstract Article PDF–442K

Select item 882889515.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 850728616.

ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

Liang Wang, Yinfeng Lyu, Yuqing Li, Kunping Li, Hui Wen, Chenchen Feng, Ning Li

Aging (Albany NY) 2021 Sep 30; 13(18): 22286–22297. Published online 2021 Sep 18. doi: 10.18632/aging.203534

Correction in:: Aging (Albany NY). 2023 Oct 31; 15(20): 11690–11691.

PMCID:: PMC8507286

Abstract Article PDF–1.5M

Select item 848665217.

Measurable residual disease of canonical versus non-canonical DNMT3A, TET2, or ASXL1 mutations in AML at stem cell transplantation

Madlen Jentzsch, Juliane Grimm, Marius Bill, Johannes Küpper, Donata Backhaus, Dominic Brauer, Julia Schulz, Georg-Nikolaus Franke, Vladan Vucinic, Dietger Niederwieser, Uwe Platzbecker, Sebastian Schwind

Bone Marrow Transplant. 2021; 56(10): 2610–2612. Published online 2021 Jul 15. doi: 10.1038/s41409-021-01407-6

PMCID:: PMC8486652

Article PDF–598K

Select item 848332118.

Proteomic analysis identifies novel binding partners of BAP1

Roy Baas, Fenna J. van der Wal, Onno B. Bleijerveld, Haico van Attikum, Titia K. Sixma

PLoS One. 2021; 16(9): e0257688. Published online 2021 Sep 30. doi: 10.1371/journal.pone.0257688

PMCID:: PMC8483321

Abstract Article PDF–2.6M

Select item 846756219.

Telomere Attrition and Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease

Yi-Chun Huang, Chao-Yung Wang

Int J Mol Sci. 2021 Sep; 22(18): 9867. Published online 2021 Sep 13. doi: 10.3390/ijms22189867

PMCID:: PMC8467562

Abstract Article PDF–1.1M

Select item 845557120.

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

Nora E. Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D. Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma

Blood Cancer J. 2021 Sep; 11(9): 157. Published online 2021 Sep 21. doi: 10.1038/s41408-021-00541-0

PMCID:: PMC8455571

Abstract Article PDF–2.8M

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Transforming growth factor-beta effect on normal ovarian fibroblast NOF151 cells
Transforming growth factor-beta effect on normal ovarian fibroblast NOF151 cells
Accession: GDS5351

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Tibial muscular dystrophy
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