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Select item 112250821.

X‐Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells

Zhuo Yang, Shaojun Li, Chuan Zhao, Zongzheng Zhao, Juan Tan, Lu Zhang, Yuanqing Huang

Immun Inflamm Dis. 2024 Jul; 12(7): e1301. Published online 2024 Jul 5. doi: 10.1002/iid3.1301

PMCID:: PMC11225082

Abstract Article PDF–2.8M

Select item 110730462.

Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma

Mankun Wei, Uli Nurjanah, Arin Herkilini, Can Huang, Yanjun Li, Makoto Miyagishi, Shourong Wu, Vivi Kasim

Cell Mol Life Sci. 2022 Sep; 79(9): 472. Published online 2022 Aug 6. doi: 10.1007/s00018-022-04504-x

PMCID:: PMC11073046

Abstract Article PDF–14M

Select item 110598683.

Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma

HUI-TING HSU, YUEH-MIN LIN, MING-TAI HSING, KUN-TU YEH, JENG-WEI LU, SHUN-FA YANG

In Vivo. 2024 May-Jun; 38(3): 1316–1324. Published online 2024 May 3. doi: 10.21873/invivo.13571

PMCID:: PMC11059868

Abstract Article PDF–3.2M

Select item 108391424.

Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients

Mohammadkian Zarafshani, Habibollah Mahmoodzadeh, Vahid Soleimani, Mohammad Amin Moosavi, Marveh Rahmati

Iran J Med Sci. 2024 Jan; 49(1): 10–21. Published online 2024 Jan 1. doi: 10.30476/IJMS.2023.96922.2856

PMCID:: PMC10839142

Abstract Article PDF–1.2M

Select item 107786695.

miRNA-378 Is Downregulated by XBP1 and Inhibits Growth and Migration of Luminal Breast Cancer Cells

Vahid Arabkari, David Barua, Muhammad Mosaraf Hossain, Mark Webber, Terry Smith, Ananya Gupta, Sanjeev Gupta

Int J Mol Sci. 2024 Jan; 25(1): 186. Published online 2023 Dec 22. doi: 10.3390/ijms25010186

PMCID:: PMC10778669

Abstract Article PDF–3.2M

Select item 105463916.

The Role of XBP1 in bone metabolism

Wenhao Lv, Youli Zheng, Junjun Jiao, Yu Fu, Tingrui Xu, Li Zhang, Zheng Zhang, Ning Ma

Front Endocrinol (Lausanne) 2023; 14: 1217579. Published online 2023 Sep 19. doi: 10.3389/fendo.2023.1217579

PMCID:: PMC10546391

Abstract Article PDF–1.0M

Select item 104987667.

Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid

Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels

Front Immunol. 2023; 14: 1204126. Published online 2023 Aug 30. doi: 10.3389/fimmu.2023.1204126

PMCID:: PMC10498766

Abstract Article PDF–3.8M

Select item 104704938.

The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection

Jessica M. Oda, Andreas B. den Hartigh, Shoen M. Jackson, Ana R. Tronco, Susan L. Fink

mBio. 2023 Jul-Aug; 14(4): e00540-23. Published online 2023 Jun 12. doi: 10.1128/mbio.00540-23

PMCID:: PMC10470493

Abstract Article PDF–832K

Select item 99171459.

Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress

Tsung-Lang Chiu, Hsin-Yi Huang, Hui-Fen Chang, Hsin-Rong Wu, Mei-Jen Wang

Int J Mol Sci. 2023 Feb; 24(3): 2017. Published online 2023 Jan 19. doi: 10.3390/ijms24032017

PMCID:: PMC9917145

Abstract Article PDF–2.7M

Select item 986359610.

Ebola Virus Activates IRE1α-Dependent XBP1u Splicing

Cornelius Rohde, Sebastian Pfeiffer, Sara Baumgart, Stephan Becker, Verena Krähling

Viruses. 2023 Jan; 15(1): 122. Published online 2022 Dec 30. doi: 10.3390/v15010122

PMCID:: PMC9863596

Abstract Article PDF–2.9M

Select item 983987611.

XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng

Clin Transl Med. 2023 Jan; 13(1): e1166. Published online 2023 Jan 13. doi: 10.1002/ctm2.1166

PMCID:: PMC9839876

Abstract Article PDF–6.1M

Select item 962397912.

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality

Arti T. Navare, Fred D. Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell L. Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe-Huntington, Mike Tyers, John D. Aitchison

J Cell Biol. 2022 Nov 7; 221(11): e202011050. Published online 2022 Oct 28. doi: 10.1083/jcb.202011050

PMCID:: PMC9623979

Abstract Article PDF–3.7M

Select item 960024813.

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss

mBio. 2022 Sep-Oct; 13(5): e02415-22. Published online 2022 Sep 20. doi: 10.1128/mbio.02415-22

PMCID:: PMC9600248

Abstract Article PDF–3.8M

Select item 958632114.

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation

Shuai Yang, Hua Jiang, Weixiang Bian, Wenyan Xu, Yifan Guo, Sha Song, Jiadong Zheng, Xiaoyu Kuang, Chenxi Wu, Xiang Ding, Xiaowei Guo, Lei Xue, Zijing Yu, Yongdeng Zhang, Hyung Don Ryoo, Xu Li, Xianjue Ma

Proc Natl Acad Sci U S A. 2022 Oct 18; 119(42): e2202133119. Published online 2022 Oct 10. doi: 10.1073/pnas.2202133119

PMCID:: PMC9586321

Abstract Article PDF–4.4M

Select item 951717315.

Crosstalk of the IκB kinase with spliced X-box binding protein 1 couples inflammation with glucose metabolic reprogramming in epithelial-mesenchymal transition

Yingxin Zhao, Jing Zhang, Hong Sun, Allan R Brasier

J Proteome Res. Author manuscript; available in PMC 2022 Sep 28.

Published in final edited form as: J Proteome Res. 2021 Jul 2; 20(7): 3475–3488. Published online 2021 Jun 14. doi: 10.1021/acs.jproteome.1c00093

PMCID:: PMC9517173

Abstract Article PDF–2.1M

Select item 940905516.

Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas

Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone

Int J Mol Sci. 2022 Aug; 23(16): 9113. Published online 2022 Aug 14. doi: 10.3390/ijms23169113