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Items: 1 to 20 of 873

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
3.
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units
Sarasi K. K. Galagedera, Thuy P. Dao, Suzanne E. Enos, Antara Chaudhuri, Jeremy D. Schmit, Carlos A. Castañeda
Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2306638120. Published online 2023 Oct 12. doi: 10.1073/pnas.2306638120
PMCID:
PMC10589717
AbstractArticlePDF–1.5M
4.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
5.
TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112125. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112125
PMCID:
PMC10435667
AbstractArticlePDF–2.3M
6.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
7.
The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia
Swapnil Rohidas Shinde, David U. Mick, Erika Aoki, Rachel B. Rodrigues, Steven P. Gygi, Maxence V. Nachury
Dev Cell. Author manuscript; available in PMC 2024 Apr 24.
Published in final edited form as: Dev Cell. 2023 Apr 24; 58(8): 677–693.e9. Published online 2023 Apr 4. doi: 10.1016/j.devcel.2023.03.003
PMCID:
PMC10133032
AbstractArticlePDF–3.4M
8.
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization
Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Nat Chem Biol. Author manuscript; available in PMC 2023 Apr 24.
Published in final edited form as: Nat Chem Biol. 2022 Apr; 18(4): 412–421. Published online 2022 Feb 24. doi: 10.1038/s41589-022-00971-2
PMCID:
PMC10125259
AbstractArticlePDF–2.8M
9.
Avidity-Based Method for the Efficient Generation of Monoubiquitinated Recombinant Proteins
Spencer L. Nelson, Yunan Li, Yue Chen, Lalit Deshmukh
J Am Chem Soc. 2023 Apr 12; 145(14): 7748–7752. Published online 2023 Apr 3. doi: 10.1021/jacs.3c01943
PMCID:
PMC10103170
AbstractArticlePDF–6.4M
10.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
11.
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis
Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu
J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054
PMCID:
PMC10040876
AbstractArticlePDF–3.0M
12.
Tsg101/ESCRT-I Recruitment Regulated by the Dual Binding Modes of K63-Linked Diubiquitin
Madeleine Strickland, Susan Watanabe, Steven M. Bonn, Christina M. Camara, Mary R. Starich, David Fushman, Carol A. Carter, Nico Tjandra
Structure. Author manuscript; available in PMC 2023 Mar 15.
Published in final edited form as: Structure. 2022 Feb 3; 30(2): 289–299.e6. doi: 10.1016/j.str.2021.09.006
PMCID:
PMC10015442
AbstractArticlePDF–2.2M
13.
Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication
Xuan Tan, Kun Cai, Jiajia Li, Zhen Yuan, Ruifeng Chen, Hurong Xiao, Chuanrui Xu, Bing Hu, Yali Qin, Binbin Ding
Cell Rep. 2023 Apr 25; 42(4): 112286. Published online 2023 Mar 10. doi: 10.1016/j.celrep.2023.112286
PMCID:
PMC9998290
AbstractArticlePDF–7.6M
14.
E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase
Georgia N. Delegkou, Maria Birkou, Nefeli Fragkaki, Tamara Toro, Konstantinos D. Marousis, Vasso Episkopou, Georgios A. Spyroulias
Cancers (Basel) 2023 Feb; 15(4): 1040. Published online 2023 Feb 7. doi: 10.3390/cancers15041040
PMCID:
PMC9954413
AbstractArticlePDF–20M
15.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition
Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, Malavika Raman
Nat Commun. 2023; 14: 638. Published online 2023 Feb 6. doi: 10.1038/s41467-023-36298-2
PMCID:
PMC9902492
AbstractArticlePDF–4.1M
16.
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling
Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer
Life Sci Alliance. 2023 Apr; 6(4): e202201607. Published online 2023 Jan 31. doi: 10.26508/lsa.202201607
PMCID:
PMC9889916
AbstractArticlePDF–2.9M
17.
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
Nat Commun. 2023; 14: 168. Published online 2023 Jan 11. doi: 10.1038/s41467-023-35871-z
PMCID:
PMC9834252
AbstractArticlePDF–4.2M
18.
Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2
Annarita Miluzio, Alessandro Cuomo, Chiara Cordiglieri, Lorena Donnici, Elisa Pesce, Mauro Bombaci, Matteo Conti, Alessandra Fasciani, Luigi Terracciano, Lara Manganaro, Mirco Toccafondi, Alessandra Scagliola, Stefania Oliveto, Sara Ricciardi, Renata Grifantini, Raffaele De Francesco, Sergio Abrignani, Nicola Manfrini, Stefano Biffo
eBioMedicine. 2023 Jan; 87: 104390. Published online 2022 Dec 28. doi: 10.1016/j.ebiom.2022.104390
PMCID:
PMC9795807
AbstractArticlePDF–4.6M
19.
Probing protein ubiquitination in live cells
Weihua Qin, Clemens Steinek, Ksenia Kolobynina, Ignasi Forné, Axel Imhof, M Cristina Cardoso, Heinrich Leonhardt
Nucleic Acids Res. 2022 Nov 28; 50(21): e125. Published online 2022 Oct 3. doi: 10.1093/nar/gkac805
PMCID:
PMC9757074
AbstractArticlePDF–8.2M
20.
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus
Zhixiao Wu, Lena A Berlemann, Verian Bader, Dominik A Sehr, Eva Dawin, Alberto Covallero, Jens Meschede, Lena Angersbach, Cathrin Showkat, Jonas B Michaelis, Christian Münch, Bettina Rieger, Dmitry Namgaladze, Maria Georgina Herrera, Fabienne C Fiesel, Wolfdieter Springer, Marta Mendes, Jennifer Stepien, Katalin Barkovits, Katrin Marcus, Albert Sickmann, Gunnar Dittmar, Karin B Busch, Dietmar Riedel, Marisa Brini, Jörg Tatzelt, Tito Cali, Konstanze F Winklhofer
EMBO J. 2022 Dec; 41(24): e112006. Published online 2022 Nov 18. doi: 10.15252/embj.2022112006
PMCID:
PMC9753471
AbstractArticlePDF–4.3M

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