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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108508182.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98430514.

ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models

Jie Li, Jingyi Lu, Manman Xu, Shiyu Yang, Tiantian Yu, Cuimiao Zheng, Xi Huang, Yuwen Pan, Yangyang Chen, Junming Long, Chunyu Zhang, Hua Huang, Qingyuan Dai, Bo Li, Wei Wang, Shuzhong Yao, Chaoyun Pan

J Clin Invest. 2023 Jan 17; 133(2): e161544. Published online 2023 Jan 17. doi: 10.1172/JCI161544

PMCID:: PMC9843051

Abstract Article PDF–2.9M

Select item 97936865.

Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1

Fanting Zeng, Yuhang Peng, Yuefeng Qin, Jianming Wang, Guoyun Jiang, Wenli Feng, Ying Yuan

Cell Commun Signal. 2022; 20: 199. Published online 2022 Dec 27. doi: 10.1186/s12964-022-01021-z

PMCID:: PMC9793686

Abstract Article PDF–17M

Select item 91775946.

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers

Zhengbo Hu, Ramya Viswanathan, Hui Cheng, Jianghong Chen, Xinping Yang, Angel Huynh, Paul Clavijo, Yi An, Yvette Robbins, Christopher Silvin, Clint Allen, Pinar Ormanoglu, Scott Martin, Shaleeka Cornelius, Anthony Saleh, Zhong Chen, Carter Van Waes, Ethan L. Morgan

Mol Cancer Res. Author manuscript; available in PMC 2022 Dec 3.

Published in final edited form as: Mol Cancer Res. 2022 Jun 3; 20(6): 867–882. doi: 10.1158/1541-7786.MCR-21-0624

PMCID:: PMC9177594

Abstract Article PDF–1.4M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89860878.

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma

Rovingaile Kriska M. Ponce, Nicholas J. Thomas, Nam Q. Bui, Tadashi Kondo, Ross A. Okimoto

JCI Insight. 2022 Mar 22; 7(6): e152293. Published online 2022 Mar 22. doi: 10.1172/jci.insight.152293

PMCID:: PMC8986087

Abstract Article PDF–5.2M

Select item 88970229.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 881658810.

miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1

Jianwu Gong, Zhi Tang, Zhengtao Yu, Zhiyong Deng, Yan Liu, Nianjun Ren, Lei Wang, Zhengwen He

Anal Cell Pathol (Amst) 2022; 2022: 7809882. Published online 2022 Jan 28. doi: 10.1155/2022/7809882

PMCID:: PMC8816588

Abstract Article PDF–3.3M

Select item 876907211.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 861922412.

Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na⁺ Channel 1.2 Macromolecular Complex

Nolan M. Dvorak, Cynthia M. Tapia, Timothy J. Baumgartner, Jully Singh, Fernanda Laezza, Aditya K. Singh

Cells. 2021 Nov; 10(11): 3103. Published online 2021 Nov 10. doi: 10.3390/cells10113103

PMCID:: PMC8619224

Abstract Article PDF–1.7M

Select item 859136713.

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer

J. Nathaniel Diehl, Jennifer E. Klomp, Kayla R. Snare, Priya S. Hibshman, Devon R. Blake, Zane D. Kaiser, Thomas S.K. Gilbert, Elisa Baldelli, Mariaelena Pierobon, Björn Papke, Runying Yang, Richard G. Hodge, Naim U. Rashid, Emanuel F. Petricoin, III, Laura E. Herring, Lee M. Graves, Adrienne D. Cox, Channing J. Der

J Biol Chem. 2021 Nov; 297(5): 101335. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101335

PMCID:: PMC8591367

Abstract Article PDF–3.9M

Select item 835296414.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 828535015.

WEE1 Inhibitor: Clinical Development

Anthony Kong, Hisham Mehanna

Curr Oncol Rep. 2021; 23(9): 107. Published online 2021 Jul 16. doi: 10.1007/s11912-021-01098-8

PMCID:: PMC8285350

Abstract Article PDF–257K

Select item 827089816.

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability

Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng

Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w

PMCID:: PMC8270898

Abstract Article PDF–2.6M

Select item 825294017.

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Juncheng Hu, Tianci Wang, Jin Xu, Sanyun Wu, Liyuan Wang, Hexiu Su, Jue Jiang, Ming Yue, Jingchao Wang, Donghai Wang, Peng Li, Fuling Zhou, Yu Liu, Guoliang Qing, Hudan Liu

Haematologica. 2021 Jul 1; 106(7): 1816–1827. Published online 2020 Jan 9. doi: 10.3324/haematol.2019.231126

PMCID:: PMC8252940

Abstract Article PDF–2.0M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 802472819.

Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation

Xiaoliang Zhao, In‐Kyu Kim, Bhaskar Kallakury, Joeffrey J. Chahine, Eiji Iwama, Mariaelena Pierobon, Emanuel Petricoin, Justine N. McCutcheon, Yu‐Wen Zhang, Shigeki Umemura, Vincent Chen, Changli Wang, Giuseppe Giaccone

Mol Oncol. 2021 Apr; 15(4): 1130–1145. Published online 2021 Jan 26. doi: 10.1002/1878-0261.12882

PMCID:: PMC8024728

Abstract Article PDF–2.6M

Select item 798261620.

The lncRNA XIST/miR‐125b‐2‐3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer

Zhao‐lei Zeng, Jia‐huan Lu, Yun Wang, Hui Sheng, Ying‐nan Wang, Zhan‐hong Chen, Qi‐nian Wu, Jia‐Bo Zheng, Yan‐xing Chen, Dong‐dong Yang, Kai Yu, Hai‐yu Mo, Jia‐jia Hu, Pei‐shan Hu, Ze‐xian Liu, Huai‐qiang Ju, Rui‐Hua Xu

Cancer Med. 2021 Apr; 10(7): 2423–2441. Published online 2021 Mar 5. doi: 10.1002/cam4.3777

PMCID:: PMC7982616

Abstract Article PDF–2.7M

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