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Select item 101516151.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 101191482.

Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank

Cezary Cybulski, Neda Zamani, Wojciech Kluźniak, Larissa Milano, Dominika Wokołorczyk, Klaudia Stempa, Helena Rudnicka, Shiyu Zhang, Maryam Zadeh, Tomasz Huzarski, Anna Jakubowska, Tadeusz Dębniak, Marcin Lener, Marek Szwiec, Paweł Domagała, Amir Abbas Samani, Steven Narod, Jacek Gronwald, Jean-Yves Masson, Jan Lubiński, Mohammad R. Akbari

Am J Hum Genet. 2023 Apr 6; 110(4): 648–662. Published online 2023 Mar 27. doi: 10.1016/j.ajhg.2023.03.002

PMCID:: PMC10119148

Abstract Article PDF–3.6M

Select item 92316233.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 87860374.

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

Amit Kulkarni, Kumuda C. Das

Am J Physiol Lung Cell Mol Physiol. Author manuscript; available in PMC 2022 Jan 24.

Published in final edited form as: Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5): L998–L1006. Published online 2008 Mar 14. doi: 10.1152/ajplung.00004.2008

PMCID:: PMC8786037

Abstract Article PDF–1.8M

Select item 84909975.

BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters

Ashari R Kannangara, Daniel M Poole, Colten M McEwan, Joshua C Youngs, Vajira K Weerasekara, Alex M Thornock, Misael T Lazaro, Eranga R Balasooriya, Laura M Oh, Erik J Soderblom, Jonathan J Lee, Daniel L Simmons, Joshua L Andersen

EMBO Rep. 2021 Oct 5; 22(10): e51136. Published online 2021 Aug 9. doi: 10.15252/embr.202051136

PMCID:: PMC8490997

Abstract Article PDF–4.5M

Select item 83529646.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81080938.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 75915779.

ATRIP protects progenitor cells against DNA damage in vivo

Gabriel E. Matos-Rodrigues, Paulius Grigaravicius, Bernard S. Lopez, Thomas Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins

Cell Death Dis. 2020 Oct; 11(10): 923. Published online 2020 Oct 28. doi: 10.1038/s41419-020-03090-9

Correction in:: Cell Death Dis. 2020 Dec; 11(12): 1074.

PMCID:: PMC7591577

Abstract Article PDF–3.4M

Select item 729003210.

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia

Nat Commun. 2020; 11: 2948. Published online 2020 Jun 11. doi: 10.1038/s41467-020-16718-3

PMCID:: PMC7290032

Abstract Article PDF–3.0M

Select item 687656611.

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Wootae Kim, Fei Zhao, Rentian Wu, Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou, Jian Yuan

Nat Commun. 2019; 10: 5304. Published online 2019 Nov 22. doi: 10.1038/s41467-019-13321-z

PMCID:: PMC6876566

Abstract Article PDF–1.8M

Select item 676324212.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 673353713.

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation

Cristina Guardia-Laguarta, Yuhui Liu, Knut H. Lauritzen, Hediye Erdjument-Bromage, Brittany Martin, Theresa C. Swayne, Xuejun Jiang, Serge Przedborski

J Neurosci. 2019 Sep 4; 39(36): 7074–7085. doi: 10.1523/JNEUROSCI.1691-18.2019

PMCID:: PMC6733537

Abstract Article PDF–3.0M

Select item 654486414.

Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation

Vaughn Thada, David Cortez

J Biol Chem. 2019 May 24; 294(21): 8395–8402. Published online 2019 Apr 2. doi: 10.1074/jbc.RA119.008154

PMCID:: PMC6544864

Abstract Article PDF–2.0M

Select item 640127615.

HiPLA: High-throughput imaging Proximity Ligation Assay

Leonid A. Serebryannyy, Tom Misteli

Methods. Author manuscript; available in PMC 2020 Mar 15.

Published in final edited form as: Methods. 2019 Mar 15; 157: 80–87. Published online 2018 Nov 10. doi: 10.1016/j.ymeth.2018.11.004

PMCID:: PMC6401276

Abstract Article PDF–1.1M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 529500517.

Mec1/ATR, the Program Manager of Nucleic Acids Inc.

Wenyi Feng

Genes (Basel) 2017 Jan; 8(1): 10. Published online 2016 Dec 28. doi: 10.3390/genes8010010

PMCID:: PMC5295005

Abstract Article PDF–702K

Select item 524586118.

ETAA1 acts at stalled replication forks to maintain genome integrity

Thomas E. Bass, Jessica W. Luzwick, Gina Kavanaugh, Clinton Carroll, Huzefa Dungrawala, Gloria G. Glick, Michael D. Feldkamp, Reid Putney, Walter J. Chazin, David Cortez

Nat Cell Biol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Nat Cell Biol. 2016 Nov; 18(11): 1185–1195. Published online 2016 Oct 10. doi: 10.1038/ncb3415

PMCID:: PMC5245861

Abstract Article PDF–2.8M

Select item 503652719.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 484875820.

An inter‐species protein–protein interaction network across vast evolutionary distance

Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, Marc Vidal

Mol Syst Biol. 2016 Apr; 12(4): 865. Published online 2016 Apr 23. doi: 10.15252/msb.20156484

PMCID:: PMC4848758

Abstract Article PDF–2.1M

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