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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74714502.

Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans

Konstantinos Papoutsis, Alkistis Kapelouzou, Georgios Georgiopoulos, Christos Kontogiannis, Christos Kourek, Konstantinos S Mylonas, Nikolaos Patelis, Dennis V Cokkinos, Ioannis Karavokyros, Sotirios Georgopoulos

Acta Pharmacol Sin. 2020 Jun; 41(6): 745–752. Published online 2020 Feb 5. doi: 10.1038/s41401-019-0350-5

PMCID:: PMC7471450

Abstract Article PDF–1.8M

Select item 62893303.

Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis

Konstantinos Papoutsis, Alkistis Kapelouzou, Diamantis I Tsilimigras, Nikolaos Patelis, Georgios Kouvelos, Dimitrios Schizas, Ioannis Karavokyros, Sotirios Georgopoulos

Acta Pharmacol Sin. 2018 Jul; 39(7): 1243–1248. Published online 2018 Mar 22. doi: 10.1038/aps.2018.8

PMCID:: PMC6289330

Abstract Article PDF–226K

Select item 59710084.

Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma

NORIHISA SAEKI, AKIRA SAITO, YUKI SUGAYA, MITSUHIRO AMEMIYA, HIROE ONO, RIE KOMATSUZAKI, KAZUYOSHI YANAGIHARA, HIROKI SASAKI

Cancer Genomics Proteomics. 2018 May-Jun; 15(3): 165–174. Published online 2018 May 3. doi: 10.21873/cgp.20074

PMCID:: PMC5971008

Abstract Article PDF–470K

Select item 48374825.

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley

Nat Commun. 2016; 7: 11344. Published online 2016 Apr 18. doi: 10.1038/ncomms11344

PMCID:: PMC4837482

Abstract Article PDF–889K

Select item 47284256.

Enhanced serelaxin signalling in co‐cultures of human primary endothelial and smooth muscle cells

M Sarwar, C S Samuel, R A Bathgate, D R Stewart, R J Summers

Br J Pharmacol. 2016 Feb; 173(3): 484–496. Published online 2016 Jan 15. doi: 10.1111/bph.13371

PMCID:: PMC4728425

Abstract Article PDF–2.1M

Select item 45368957.

Physical fitness, serum relaxin and duration of gestation

Eva Thorell, Laura Goldsmith, Gerson Weiss, Per Kristiansson

BMC Pregnancy Childbirth. 2015; 15: 168. Published online 2015 Aug 14. doi: 10.1186/s12884-015-0607-z

PMCID:: PMC4536895

Abstract Article PDF–604K

Select item 45035848.

RLN2 Is a Positive Regulator of AKT-2-Induced Gene Expression Required for Osteosarcoma Cells Invasion and Chemoresistance

Jinfeng Ma, Hai Huang, Zenggang Han, Changzheng Zhu, Bin Yue

Biomed Res Int. 2015; 2015: 147468. Published online 2015 Jul 1. doi: 10.1155/2015/147468

PMCID:: PMC4503584

Abstract Article PDF–1.6M

Select item 43175779.

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B. Nair, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed Akhter Hossain, John D. Wade

Biomed Res Int. 2015; 2015: 731852. Published online 2015 Jan 22. doi: 10.1155/2015/731852

PMCID:: PMC4317577

Abstract Article PDF–1.0M

Select item 426969310.

Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension

Jennifer M. Sasser, Mark W. Cunningham, Jr., Chris Baylis

Am J Physiol Renal Physiol. 2014 Dec 15; 307(12): F1355–F1362. Published online 2014 Oct 8. doi: 10.1152/ajprenal.00407.2014

PMCID:: PMC4269693

Abstract Article

Select item 424385811.

Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23–27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

M Kocan, M Sarwar, M A Hossain, J D Wade, R J Summers

Br J Pharmacol. 2014 Jun; 171(11): 2827–2841. Published online 2014 May 15. doi: 10.1111/bph.12623

PMCID:: PMC4243858

Abstract Article PDF–2.8M

Select item 395970712.

Acute Intravenous Injection of Serelaxin (Recombinant Human Relaxin‐2) Causes Rapid and Sustained Bradykinin‐Mediated Vasorelaxation

Chen Huei Leo, Maria Jelinic, Helena C. Parkington, Marianne Tare, Laura J. Parry

J Am Heart Assoc. 2014 Feb; 3(1): e000493. Published online 2014 Feb 28. doi: 10.1161/JAHA.113.000493

PMCID:: PMC3959707

Abstract Article PDF–826K

Select item 375842013.

Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes

Frederico G. ROCHA, Thomas P. SLAVIN, Dongmei LI, Maarit I. TIIRIKAINEN, Gillian D. BRYANT-GREENWOOD

Am J Obstet Gynecol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Am J Obstet Gynecol. 2013 Sep; 209(3): 258.e1–258.e8. Published online 2013 May 10. doi: 10.1016/j.ajog.2013.05.020

PMCID:: PMC3758420

Abstract Article PDF–654K

Select item 363199514.

Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma

Peng Ren, Zhen-Tao Yu, Li Xiu, Mei Wang, Hua-Min Liu

World J Gastroenterol. 2013 Apr 21; 19(15): 2412–2418. Published online 2013 Apr 21. doi: 10.3748/wjg.v19.i15.2412

PMCID:: PMC3631995

Abstract Article PDF–911K

Select item 351081515.

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J. Chan, K. Johan Rosengren, Sharon L. Layfield, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed A. Hossain, John D. Wade

J Biol Chem. 2012 Nov 30; 287(49): 41152–41164. Published online 2012 Sep 28. doi: 10.1074/jbc.M112.409284

PMCID:: PMC3510815

Abstract Article PDF–2.5M

Select item 342327116.

Cellular Retrograde Cardiomyoplasty and Relaxin Therapy for Postischemic Myocardial Repair in a Rat Model

Gabriella Di Lascio, Guy Harmelin, Mattia Targetti, Cristina Nanni, Giacomo Bianchi, Tommaso Gasbarri, Sandro Gelsomino, Daniele Bani, Sandra Zecchi Orlandini, Massimo Bonacchi

Tex Heart Inst J. 2012; 39(4): 488–499.

PMCID:: PMC3423271

Abstract Article PDF–1.2M

Select item 338086817.

A Novel Role for Relaxin-2 in the Pathogenesis of Primary Varicosis

Julia Adams, Sarah Schott, Arno Bern, Matthias Renz, Kristian Ikenberg, Claus Garbe, Christian Busch

PLoS One. 2012; 7(6): e39021. Published online 2012 Jun 21. doi: 10.1371/journal.pone.0039021

PMCID:: PMC3380868

Abstract Article PDF–1.0M

Select item 324964818.

Dual Blockade of PKA and NF–κB Inhibits H2 Relaxin-Mediated Castrate-Resistant Growth of Prostate Cancer Sublines and Induces Apoptosis

Ruth L. Vinall, Christopher M. Mahaffey, Ryan R. Davis, Zunping Luo, Regina Gandour-Edwards, Paramita M. Ghosh, Clifford G. Tepper, Ralph W. de Vere White

Horm Cancer. 2011 Aug; 2(4): 224–238. Published online 2011 Jul 26. doi: 10.1007/s12672-011-0076-4

PMCID:: PMC3249648

Abstract Article PDF–720K

Select item 319950119.

The Minimal Active Structure of Human Relaxin-2

Mohammed Akhter Hossain, K. Johan Rosengren, Chrishan S. Samuel, Fazel Shabanpoor, Linda J. Chan, Ross A. D. Bathgate, John D. Wade

J Biol Chem. 2011 Oct 28; 286(43): 37555–37565. Published online 2011 Aug 30. doi: 10.1074/jbc.M111.282194

PMCID:: PMC3199501

Abstract Article PDF–2.3M

Select item 273408120.

DNA sequence and analysis of human chromosome 9

S. J. Humphray, K. Oliver, A. R. Hunt, R. W. Plumb, J. E. Loveland, K. L. Howe, T. D. Andrews, S. Searle, S. E. Hunt, C. E. Scott, M. C. Jones, R. Ainscough, J. P. Almeida, K. D. Ambrose, R. I. S. Ashwell, A. K. Babbage, S. Babbage, C. L. Bagguley, J. Bailey, R. Banerjee, D. J. Barker, K. F. Barlow, K. Bates, H. Beasley, O. Beasley, C. P. Bird, S. Bray-Allen, A. J. Brown, J. Y. Brown, D. Burford, W. Burrill, J. Burton, C. Carder, N. P. Carter, J. C. Chapman, Y. Chen, G. Clarke, S. Y. Clark, C. M. Clee, S. Clegg, R. E. Collier, N. Corby, M. Crosier, A. T. Cummings, J. Davies, P. Dhami, M. Dunn, I. Dutta, L. W. Dyer, M. E. Earthrowl, L. Faulkner, C. J. Fleming, A. Frankish, J. A. Frankland, L. French, D. G. Fricker, P. Garner, J. Garnett, J. Ghori, J. G. R. Gilbert, C. Glison, D. V. Grafham, S. Gribble, C. Griffiths, S. Griffiths-Jones, R. Grocock, J. Guy, R. E. Hall, S. Hammond, J. L. Harley, E. S. I. Harrison, E. A. Hart, P. D. Heath, C. D. Henderson, B. L. Hopkins, P. J. Howard, P. J. Howden, E. Huckle, C. Johnson, D. Johnson, A. A. Joy, M. Kay, S. Keenan, J. K. Kershaw, A. M. Kimberley, A. King, A. Knights, G. K. Laird, C. Langford, S. Lawlor, D. A. Leongamornlert, M. Leversha, C. Lloyd, D. M. Lloyd, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, L. Matthews, S. McLaren, K. E. McLay, A. McMurray, S. Milne, T. Nickerson, J. Nisbett, G. Nordsiek, A. V. Pearce, A. I. Peck, K. M. Porter, R. Pandian, S. Pelan, B. Phillimore, S. Povey, Y. Ramsey, V. Rand, M. Scharfe, H. K. Sehra, R. Shownkeen, S. K. Sims, C. D. Skuce, M. Smith, C. A. Steward, D. Swarbreck, N. Sycamore, J. Tester, A. Thorpe, A. Tracey, A. Tromans, D. W. Thomas, M. Wall, J. M. Wallis, A. P. West, S. L. Whitehead, D. L. Willey, S. A. Williams, L. Wilming, P. W. Wray, L. Young, J. L. Ashurst, A. Coulson, H. Blöcker, R. Durbin, J. E. Sulston, T. Hubbard, M. J. Jackson, D. R. Bentley, S. Beck, J. Rogers, I. Dunham

Nature. Author manuscript; available in PMC 2009 Aug 28.

Published in final edited form as: Nature. 2004 May 27; 429(6990): 369–374. doi: 10.1038/nature02465

PMCID:: PMC2734081

Abstract Article PDF–1006K

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