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Select item 108282381.

Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging

Rezvan Noroozi, Joanna Rudnicka, Aleksandra Pisarek, Bożena Wysocka, Aleksander Masny, Michał Boroń, Kamila Migacz-Gruszka, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Dagmara Lisman, Grażyna Zielińska, Aleksandra Iljin, Joanna A. Wiktorska, Małgorzata Michalczyk, Piotr Kaczka, Michał Krzysztofik, Aneta Sitek, Andrzej Ossowski, Magdalena Spólnicka, Wojciech Branicki, Ewelina Pośpiech

GeroScience. 2024 Apr; 46(2): 2583–2604. Published online 2023 Dec 16. doi: 10.1007/s11357-023-01029-4

PMCID:: PMC10828238

Abstract Article PDF–1.5M

Select item 107104682.

SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway

Yong Lv, Xiaolong Xie, Guoyou Zou, Meng Kong, Jiayin Yang, Jing Chen, Bo Xiang

Sci Rep. 2023; 13: 21814. Published online 2023 Dec 9. doi: 10.1038/s41598-023-48591-7

PMCID:: PMC10710468

Abstract Article PDF–9.0M

Select item 101280823.

MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A

Kaiqiong Wang, Dongwei Gong, Xin Qiao, Jinfang Zheng

Life Sci Alliance. 2023 May; 6(5): e202201703. Published online 2023 Apr 21. doi: 10.26508/lsa.202201703

PMCID:: PMC10128082

Abstract Article PDF–4.9M

Select item 98834494.

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma

Qianping Chen, Wang Zheng, Jian Guan, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou, Xinrui Zhao, Yuhong Zhang, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao

Cell Death Differ. 2023 Jan; 30(1): 137–151. Published online 2022 Aug 22. doi: 10.1038/s41418-022-01051-7

PMCID:: PMC9883449

Abstract Article PDF–7.3M

Select item 89737455.

miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2)

Yanhong Tu, Fan Mei

Bioengineered. 2022; 13(2): 3044–3056. Published online 2022 Jan 17. doi: 10.1080/21655979.2021.2017577

PMCID:: PMC8973745

Abstract Article PDF–3.4M

Select item 88068356.

MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2)

Jinlong Xu, Jinmei Wang, Lili Liu, Lin Chen, Songliu Hu, Feng Liu

Bioengineered. 2021; 12(1): 7737–7746. Published online 2021 Oct 4. doi: 10.1080/21655979.2021.1982329

PMCID:: PMC8806835

Abstract Article PDF–1.4M

Select item 86400197.

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson

Nat Commun. 2021; 12: 7032. Published online 2021 Dec 2. doi: 10.1038/s41467-021-26983-5

Correction in:: Nat Commun. 2023; 14: 7951.

PMCID:: PMC8640019

Abstract Article PDF–4.4M

Select item 86065888.

Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

Xi-Yuan Liu, Rui Lu, Jing Chen, Jie Wang, Hong-Mei Qian, Gang Chen, Rong-Han Wu, Zai-Long Chi

Front Neurosci. 2021; 15: 738022. Published online 2021 Nov 8. doi: 10.3389/fnins.2021.738022

PMCID:: PMC8606588

Abstract Article PDF–4.8M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 738824810.

m⁶A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation

Jihao Xu, Qikui Chen, Kuangyi Tian, Rongrong Liang, Ting Chen, Aiyu Gong, Nicholas W. Mathy, Tao Yu, Xianming Chen

Oncol Rep. 2020 Sep; 44(3): 973–986. Published online 2020 Jun 26. doi: 10.3892/or.2020.7665

PMCID:: PMC7388248

Abstract Article PDF–1.8M

Select item 734814511.

LncRNA WDFY3‐AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR‐2355‐5p/SOCS2 axis

Qing Zhang, Fangxia Guan, Tianli Fan, Shenglei Li, Shanshan Ma, Yanting Zhang, Wenna Guo, Hongtao Liu

J Cell Mol Med. 2020 Jul; 24(14): 8206–8220. Published online 2020 Jun 14. doi: 10.1111/jcmm.15488

PMCID:: PMC7348145

Abstract Article PDF–2.7M

Select item 734604112.

LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264

Zhihai Zheng, Xiaoxiao Li, Heyi You, Xiaofeng Zheng, Xiaojiao Ruan

Aging (Albany NY) 2020 Jun 15; 12(11): 10517–10526. Published online 2020 May 21. doi: 10.18632/aging.103276

PMCID:: PMC7346041

Abstract Article PDF–2.3M

Select item 732206713.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 716998314.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 715369515.

ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008

PMCID:: PMC7153695

Abstract Article PDF–2.6M

Select item 679539916.

KIAA0317 regulates pulmonary inflammation through SOCS2 degradation

Travis B. Lear, Alison C. McKelvey, John W. Evankovich, Shristi Rajbhandari, Tiffany A. Coon, Sarah R. Dunn, James D. Londino, Bryan J. McVerry, Yingze Zhang, Eleanor Valenzi, Christine L. Burton, Rachael Gordon, Sebastien Gingras, Karina C. Lockwood, Michael J. Jurczak, Robert Lafyatis, Mark J. Shlomchik, Yuan Liu, Bill B. Chen

JCI Insight. 2019 Oct 3; 4(19): e129110. Published online 2019 Oct 3. doi: 10.1172/jci.insight.129110

PMCID:: PMC6795399

Abstract Article PDF–50M

Select item 659151017.

SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness

Chi Huu Nguyen, Tobias Glüxam, Angela Schlerka, Katharina Bauer, Alexander M. Grandits, Hubert Hackl, Oliver Dovey, Sabine Zöchbauer-Müller, Jonathan L. Cooper, George S. Vassiliou, Dagmar Stoiber, Rotraud Wieser, Gerwin Heller

Sci Rep. 2019; 9: 9139. Published online 2019 Jun 24. doi: 10.1038/s41598-019-45579-0

PMCID:: PMC6591510

Abstract Article PDF–1.9M

Select item 629936818.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 624576619.

Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer

Soudeh Ghafouri-Fard, Vahid Kholghi Oskooei, Iman Azari, Mohammad Taheri

World J Surg Oncol. 2018; 16: 226. Published online 2018 Nov 19. doi: 10.1186/s12957-018-1529-9

PMCID:: PMC6245766

Abstract Article PDF–560K

Select item 613844120.

CRL4^AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling

Si‐Han Chen, Gwendolyn M Jang, Ruth Hüttenhain, David E Gordon, Dan Du, Billy W Newton, Jeffrey R Johnson, Joseph Hiatt, Judd F Hultquist, Tasha L Johnson, Yi‐Liang Liu, Lily A Burton, Jordan Ye, Kurt M Reichermeier, Robert M Stroud, Alexander Marson, Jayanta Debnath, John D Gross, Nevan J Krogan

EMBO J. 2018 Sep 14; 37(18): e97508. Published online 2018 Aug 30. doi: 10.15252/embj.201797508

PMCID:: PMC6138441

Abstract Article PDF–1.7M

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