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Select item 111593471.

Involvement of thioredoxin‐binding protein 2 in the antitumor activity of CD437

Saori Matsuoka, Hiroyuki Tsuchiya, Tomohiko Sakabe, Yumi Watanabe, Yoshiko Hoshikawa, Akihiro Kurimasa, Hiroaki Itamochi, Tasuku Harada, Naoki Terakawa, Hiroshi Masutani, Junji Yodoi, Goshi Shiota

Cancer Sci. 2008 Dec; 99(12): 2485–2490. Published online 2008 Nov 19. doi: 10.1111/j.1349-7006.2008.00979.x

PMCID:: PMC11159347

Abstract Article PDF–237K

Select item 102769002.

Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability

Hemant Giri, Amit K. Srivastava, Ulhas P. Naik

Vascul Pharmacol. Author manuscript; available in PMC 2023 Jun 18.

Published in final edited form as: Vascul Pharmacol. 2022 Aug; 145: 107088. Published online 2022 Jul 4. doi: 10.1016/j.vph.2022.107088

PMCID:: PMC10276900

Abstract Article PDF–2.0M

Select item 93151263.

Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target

Vaibhav Singh, Emily Huang, Vai Pathak, Belinda B. Willard, Daniela S. Allende, Laura E. Nagy

Hepatol Commun. 2022 Aug; 6(8): 2022–2041. Published online 2022 Apr 19. doi: 10.1002/hep4.1956

PMCID:: PMC9315126

Abstract Article PDF–11M

Select item 92626144.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052356.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 87055847.

Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

Veronika Obsilova, Karolina Honzejkova, Tomas Obsil

Int J Mol Sci. 2021 Dec; 22(24): 13395. Published online 2021 Dec 13. doi: 10.3390/ijms222413395

PMCID:: PMC8705584

Abstract Article PDF–1.8M

Select item 86204958.

MEKK5 Interacts with and Negatively Regulates the E3 Ubiquitin Ligase NEDD4 for Mediating Lung Cancer Cell Migration

Aiqin Sun, Jun Zhu, Song Xia, Yanling Li, Tiantian Wu, Genbao Shao, Wannian Yang, Qiong Lin

Life (Basel) 2021 Nov; 11(11): 1153. Published online 2021 Oct 29. doi: 10.3390/life11111153

PMCID:: PMC8620495

Abstract Article PDF–2.4M

Select item 83289189.

Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibition Reduces Endothelial Cytokine Production without Improving Permeability after Toll-like Receptor 4 (TLR4) Challenge

Michael R. Miller, Stephen R. Koch, Hyehun Choi, Fred S. Lamb, Ryan J. Stark

Transl Res. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Transl Res. 2021 Sep; 235: 115–128. Published online 2021 Apr 20. doi: 10.1016/j.trsl.2021.04.001

PMCID:: PMC8328918

Abstract Article PDF–2.0M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 803493311.

Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease

Brian J. Morris, Randi Chen, Timothy A. Donlon, Kamal H. Masaki, D. Craig Willcox, Richard C. Allsopp, Bradley J. Willcox

Aging (Albany NY) 2021 Mar 31; 13(6): 7953–7974. Published online 2021 Mar 19. doi: 10.18632/aging.202844

PMCID:: PMC8034933

Abstract Article PDF–1.3M

Select item 794647912.

Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris

Bin Wei, Fenghe Li

Biomed Res Int. 2021; 2021: 2471518. Published online 2021 Feb 23. doi: 10.1155/2021/2471518

PMCID:: PMC7946479

Abstract Article PDF–2.9M

Select item 766936013.

ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes

Pei-pei Fang, Chen-wei Pan, Wei Lin, Jie Li, Shan-shan Huang, Guang-yao Zhou, Wen-jun Du, Qiang Li

Mediators Inflamm. 2020; 2020: 8183713. Published online 2020 Nov 7. doi: 10.1155/2020/8183713

PMCID:: PMC7669360

Abstract Article PDF–3.5M

Select item 738632614.

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

M Won, KA Park, HS Byun, K-C Sohn, Y-R Kim, J Jeon, JH Hong, J Park, JH Seok, JM Kim, W-H Yoon, I-S Jang, HM Shen, ZG Liu, GM Hur

Cell Death Differ. Author manuscript; available in PMC 2020 Jul 28.

Published in final edited form as: Cell Death Differ. 2010 Dec; 17(12): 1830–1841. Published online 2010 May 7. doi: 10.1038/cdd.2010.47

PMCID:: PMC7386326

Abstract Article PDF–4.3M

Select item 734816715.

ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6‐mediated Lysine 6‐linked polyubiquitination of ASK1 in hepatocytes

Xiaoliang Xu, Zechuan Zhang, Yijun Lu, Qikai Sun, Yang Liu, Qiaoyu Liu, Wenfang Tian, Yin Yin, Hailong Yu, Beicheng Sun

J Cell Mol Med. 2020 Jul; 24(14): 7814–7828. Published online 2020 May 23. doi: 10.1111/jcmm.15412

PMCID:: PMC7348167

Abstract Article PDF–2.5M

Select item 719187916.

Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1

Lauren Rusnak, Cong Tang, Qi Qi, Xiulei Mo, Haian Fu

J Mol Cell Biol. 2018 Dec; 10(6): 549–558. Published online 2018 Nov 29. doi: 10.1093/jmcb/mjy061

PMCID:: PMC7191879

Abstract Article PDF–544K

Select item 707173217.

Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets

Pravin Patel, Meghna U. Naik, Kalyan Golla, Noor F. Shaik, Ulhas P. Naik

Biochem J. Author manuscript; available in PMC 2020 Oct 15.

Published in final edited form as: Biochem J. 2019 Oct 15; 476(19): 2835–2850. doi: 10.1042/BCJ20190410

PMCID:: PMC7071732

Abstract Article PDF–1.6M

Select item 698120618.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 678364419.

Liver ASK1 protects from non‐alcoholic fatty liver disease and fibrosis

Tenagne D Challa, Stephan Wueest, Fabrizio C Lucchini, Mara Dedual, Salvatore Modica, Marcela Borsigova, Christian Wolfrum, Matthias Blüher, Daniel Konrad

EMBO Mol Med. 2019 Oct; 11(10): e10124. Published online 2019 Jun 6. doi: 10.15252/emmm.201810124

PMCID:: PMC6783644

Abstract Article PDF–1.7M

Select item 677813720.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

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