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Select item 111220471.

Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells

Lucia Cappabianca, Marianna Ruggieri, Michela Sebastiano, Maddalena Sbaffone, Ilaria Martelli, Pierdomenico Ruggeri, Monica Di Padova, Antonietta Rosella Farina, Andrew Reay Mackay

Int J Mol Sci. 2024 May; 25(10): 5475. Published online 2024 May 17. doi: 10.3390/ijms25105475

PMCID:: PMC11122047

Abstract Article PDF–14M

Select item 107825852.

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression

Yu Zhang, Zhenlin Huang, Keqiang Li, Guoqing Xie, Yuankang Feng, Zihao Wang, Ningyang Li, Ruoyang Liu, Yinghui Ding, Jun Wang, Jinjian Yang, Zhankui Jia

J Exp Clin Cancer Res. 2024; 43: 16. Published online 2024 Jan 11. doi: 10.1186/s13046-023-02920-w

PMCID:: PMC10782585

Abstract Article PDF–11M

Select item 103105653.

Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors

Yoichi Naito, Saori Mishima, Kiwamu Akagi, Naomi Hayashi, Akira Hirasawa, Tomoro Hishiki, Ataru Igarashi, Masafumi Ikeda, Shigenori Kadowaki, Hiroaki Kajiyama, Motohiro Kato, Hirotsugu Kenmotsu, Yasuhiro Kodera, Keigo Komine, Takafumi Koyama, Osamu Maeda, Mitsuru Miyachi, Hiroshi Nishihara, Hiroyuki Nishiyama, Shouichi Ohga, Wataru Okamoto, Eiji Oki, Shigeru Ono, Masashi Sanada, Ikuo Sekine, Tadao Takano, Kayoko Tao, Keita Terashima, Katsuya Tsuchihara, Yasushi Yatabe, Takayuki Yoshino, Eishi Baba

Int J Clin Oncol. 2023; 28(7): 827–840. Published online 2023 May 22. doi: 10.1007/s10147-023-02345-7

PMCID:: PMC10310565

Abstract Article PDF–779K

Select item 101055614.

Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines

Bo Jiao, Mi Zhang, Caixia Zhang, Xueqin Cao, Baowen Liu, Ningbo Li, Jiaoli Sun, Xianwei Zhang

PeerJ. 2023; 11: e15219. Published online 2023 Apr 12. doi: 10.7717/peerj.15219

PMCID:: PMC10105561

Abstract Article PDF–8.4M

Select item 100775105.

Human TrkA^R649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV

Paola Pacifico, Giovanna Testa, Rosy Amodeo, Marco Mainardi, Alexia Tiberi, Domenica Convertino, Juan Carlos Arevalo, Laura Marchetti, Mario Costa, Antonino Cattaneo, Simona Capsoni

Hum Mol Genet. 2023 Apr 15; 32(8): 1380–1400. Published online 2022 Dec 20. doi: 10.1093/hmg/ddac295

PMCID:: PMC10077510

Abstract Article PDF–2.9M

Select item 95336666.

Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis and Pain in Oral Cancer

Coleen Doan, Bradley E. Aouizerat, Yi Ye, Dongmin Dang, Kesava Asam, Aditi Bhattacharya, Timothy Howard, Yogin K. Patel, Dan T. Viet, Johnny D. Figueroa, Jiang F. Zhong, Carissa M. Thomas, Anthony B. Morlandt, Gary Yu, Nicholas F. Callahan, Clint T. Allen, Anupama Grandhi, Alan S. Herford, Paul C. Walker, Khanh Nguyen, Stephanie C. Kidd, Steve C. Lee, Jared C. Inman, Jason M. Slater, Chi T. Viet

Adv Biol (Weinh) Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Adv Biol (Weinh). 2022 Sep; 6(9): e2200190. Published online 2022 Aug 4. doi: 10.1002/adbi.202200190

PMCID:: PMC9533666

Abstract Article PDF–1.9M

Select item 92774147.

Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1‐rearranged tumor cells

Chiaki Suzuki, Akihiro Nishiyama, Sachiko Arai, Shoichiro Tange, Atsushi Tajima, Azusa Tanimoto, Koji Fukuda, Yohei Takumi, Hiroshi Kotani, Shinji Takeuchi, Naohiro Yanagimura, Koushiro Ohtsubo, Norio Yamamoto, Koichi Omori, Seiji Yano

Cancer Sci. 2022 Jul; 113(7): 2323–2335. Published online 2022 May 11. doi: 10.1111/cas.15354

PMCID:: PMC9277414

Abstract Article PDF–5.8M

Select item 91714118.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 89625229.

Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon

J Exp Clin Cancer Res. 2022; 41: 110. Published online 2022 Mar 28. doi: 10.1186/s13046-022-02314-4

PMCID:: PMC8962522

Abstract Article PDF–6.1M

Select item 887741510.

NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism

Maritza P. Garrido, Christopher Vallejos, Silvanna Girardi, Fernando Gabler, Alberto Selman, Fernanda López, Margarita Vega, Carmen Romero

Int J Mol Sci. 2022 Feb; 23(4): 2124. Published online 2022 Feb 15. doi: 10.3390/ijms23042124

PMCID:: PMC8877415

Abstract Article PDF–3.1M

Select item 883051311.

Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion–Positive Lung Cancers

Alexander Drilon, Daniel S. W. Tan, Ulrik N. Lassen, Serge Leyvraz, Yongmei Liu, Jyoti D. Patel, Lee Rosen, Benjamin Solomon, Ricarda Norenberg, Laura Dima, Nicoletta Brega, Lin Shen, Victor Moreno, Shivaani Kummar, Jessica J. Lin

JCO Precis Oncol. 2022; 6: e2100418. Published online 2022 Jan 27. doi: 10.1200/PO.21.00418

PMCID:: PMC8830513

Abstract Article PDF–544K

Select item 879573612.

The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19

Carla Usai, Joseph M. Gibbons, Corinna Pade, Wenhao Li, Sabina R. M. Jacobs, Áine McKnight, Patrick T. F. Kennedy, Upkar S. Gill

Front Immunol. 2021; 12: 813300. Published online 2022 Jan 14. doi: 10.3389/fimmu.2021.813300

PMCID:: PMC8795736

Abstract Article PDF–6.3M

Select item 870887913.

Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease

Klaudia Barabás, Julianna Kobolák, Soma Godó, Tamás Kovács, Dávid Ernszt, Miklós Kecskés, Csaba Varga, Tibor Z. Jánosi, Takahiro Fujiwara, Akihiro Kusumi, Annamária Téglási, András Dinnyés, István M. Ábrahám

Int J Mol Sci. 2021 Dec; 22(24): 13260. Published online 2021 Dec 9. doi: 10.3390/ijms222413260

PMCID:: PMC8708879

Abstract Article PDF–2.5M

Select item 863966814.

TRIP12 Ubiquitination of Glucocerebrosidase Contributes to Neurodegeneration in Parkinson’s Disease

Bo Am Seo, Donghoon Kim, Heehong Hwang, Min Seong Kim, Shi-Xun Ma, Seung-Hwan Kwon, Sin Ho Kweon, Hu Wang, Je Min Yoo, Seulah Choi, Sang Ho Kwon, Sung-Ung Kang, Tae-In Kam, Kwangsoo Kim, Senthilkumar S Karuppagounder, Bong Gu Kang, Saebom Lee, Hyejin Park, Sangjune Kim, Wei Yan, Yong-Shi Li, Sheng-Han Kuo, Javier Redding-Ochoa, Olga Pletnikova, Juan C. Troncoso, Gabsang Lee, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Han Seok Ko

Neuron. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Neuron. 2021 Dec 1; 109(23): 3758–3774.e11. Published online 2021 Oct 12. doi: 10.1016/j.neuron.2021.09.031

PMCID:: PMC8639668

Abstract Article PDF–2.6M

Select item 860620615.

Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis

Shang Li, Hua‐ying Hu, Jun‐Jun Xu, Zhan‐ke Feng, Yong‐qing Sun, Xu Chen, Kai Yang, Ya‐zhou Li, Dong‐liang Zhang

Mol Genet Genomic Med. 2021 Nov; 9(11): e1839. Published online 2021 Oct 21. doi: 10.1002/mgg3.1839

PMCID:: PMC8606206

Abstract Article PDF–1.2M

Select item 839260516.

Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease

Erika Kropf, Margaret Fahnestock

Cells. 2021 Aug; 10(8): 1983. Published online 2021 Aug 4. doi: 10.3390/cells10081983

PMCID:: PMC8392605

Abstract Article PDF–1.3M

Select item 835096417.

Cytomorphologic Features of NTRK-Rearranged Thyroid Carcinoma

Kartik Viswanathan, Ying-Hsia Chu, William C. Faquin, Peter M. Sadow

Cancer Cytopathol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Cancer Cytopathol. 2020 Nov; 128(11): 812–827. Published online 2020 Oct 19. doi: 10.1002/cncy.22374

PMCID:: PMC8350964

Abstract Article PDF–1.6M

Select item 795256518.

NTRK fusion in Japanese colorectal adenocarcinomas

Yuya Yamashiro, Taisei Kurihara, Takuo Hayashi, Yoshiyuki Suehara, Takashi Yao, Shunsuke Kato, Tsuyoshi Saito

Sci Rep. 2021; 11: 5635. Published online 2021 Mar 11. doi: 10.1038/s41598-021-85075-y

PMCID:: PMC7952565

Abstract Article PDF–2.2M

Select item 789846819.

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition

María Luisa Franco, Irmina García-Carpio, Raquel Comaposada-Baró, Juan J Escribano-Saiz, Lucía Chávez-Gutiérrez, Marçal Vilar

Life Sci Alliance. 2021 Apr; 4(4): e202000844. Published online 2021 Feb 3. doi: 10.26508/lsa.202000844

PMCID:: PMC7898468

Abstract Article PDF–3.2M

Select item 780647420.

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia

Chengwan Zhang, Li Shen, Yifu Zhu, Ran Xu, Zhikui Deng, Xiaoning Liu, Yihan Ding, Chunling Wang, Yuye Shi, Liye Bei, Dongping Wei, Rick F. Thorne, Xu Dong Zhang, Liang Yu, Song Chen

Theranostics. 2021; 11(6): 2691–2705. Published online 2021 Jan 1. doi: 10.7150/thno.50571

PMCID:: PMC7806474

Abstract Article PDF–3.0M

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