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Select item 111478421.

Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse

Kevin J. Bielamowicz, Mary Beth Littrell, Gregory W. Albert, Lora S. Parker, Sateesh Jayappa, Kenneth Aldape, Murat Gokden

J Neurooncol. 2024; 168(2): 367–373. Published online 2024 Apr 19. doi: 10.1007/s11060-024-04667-6

PMCID:: PMC11147842

Abstract Article PDF–1.2M

Select item 110637612.

Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors

Justin W. Magrath, Shruthi Sanjitha Sampath, Dane A. Flinchum, Alifiani B. Hartono, Ilon N. Goldberg, Julia R. Boehling, Suzana D. Savkovic, Sean B. Lee

Cancer Res. 2024 May 2; 84(9): 1426–1442. Published online 2024 Apr 8. doi: 10.1158/0008-5472.CAN-23-3334

PMCID:: PMC11063761

Abstract Article PDF–24M

Select item 108698003.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 108554204.

Identification of Novel/Rare EWSR1 Fusion Partners in Undifferentiated Mesenchymal Neoplasms

Carmen Salguero-Aranda, Elena Di Blasi, Lourdes Galán, Laura Zaldumbide, Gema Civantos, David Marcilla, Enrique de Álava, Juan Díaz-Martín

Int J Mol Sci. 2024 Feb; 25(3): 1735. Published online 2024 Feb 1. doi: 10.3390/ijms25031735

PMCID:: PMC10855420

Abstract Article PDF–3.8M

Select item 108019365.

Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma

Lili Liu, Lan Li, Yi Ding, Fangzhou Kong, Wenfa Mo, Hongtao Ye, Danhua Shen

Diagn Pathol. 2024; 19: 19. Published online 2024 Jan 22. doi: 10.1186/s13000-024-01443-y

PMCID:: PMC10801936

Abstract Article PDF–2.3M

Select item 107649586.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 107619717.

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions

Julia Schöpf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav D. Diwan, Zunamys I. Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Dominic Helm, Martin Schneider, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert B. Russell, Barbara C. Jones, Daniel B. Lipka, Hanno Glimm, Daniel Hübschmann, Wolfgang Hartmann, Stefan Fröhling, Claudia Scholl

Nat Commun. 2024; 15: 51. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44360-2

PMCID:: PMC10761971

Abstract Article PDF–3.4M

Select item 107582958.

EWSR1 (Ewing Sarcoma Breakpoint Region 1) maintains centromere identity

Risa Kitagawa, Yohei Niikura, Argentina Becker, Peter J Houghton, Katsumi Kitagawa

Cell Rep. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112568. Published online 2023 May 25. doi: 10.1016/j.celrep.2023.112568

PMCID:: PMC10758295

Abstract Article PDF–2.8M

Select item 107044319.

A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells

Benjamin M. Greulich, Saranya Rajendran, Nicholas F. Downing, Taylor R. Nicholas, Peter C. Hollenhorst

J Biol Chem. 2023 Dec; 299(12): 105453. Published online 2023 Nov 11. doi: 10.1016/j.jbc.2023.105453

PMCID:: PMC10704431

Abstract Article PDF–1.3M

Select item 1060718410.

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma

Muhammad Yasir, Jinyoung Park, Wanjoo Chun

Int J Mol Sci. 2023 Oct; 24(20): 15173. Published online 2023 Oct 14. doi: 10.3390/ijms242015173

PMCID:: PMC10607184

Abstract Article PDF–1.7M

Select item 1056587611.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1024099812.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 1023742213.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1013090514.

TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses

Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Hongjiao Wang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao, Zuliang Jie

J Exp Med. 2023 Aug 7; 220(8): e20221483. Published online 2023 Apr 25. doi: 10.1084/jem.20221483

Correction in:: J Exp Med. 2023 Aug 7; 220(8): e2022148307122023c.

PMCID:: PMC10130905

Abstract Article PDF–6.2M

Select item 1002747315.

Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding

Olivia W. Lee, Calvin Rodrigues, Shu-Hong Lin, Wen Luo, Kristine Jones, Derek W. Brown, Weiyin Zhou, Eric Karlins, Sairah M. Khan, Sylvain Baulande, Virginie Raynal, Didier Surdez, Stephanie Reynaud, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetête, Stelly Ballet, Eve Lapouble, Valérie Laurence, Gaelle Pierron, Nathalie Gaspar, Nadège Corradini, Perrine Marec-Bérard, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Michelle Manning, Kathleen Wyatt, Meredith Yeager, Raj Chari, Wendy M. Leisenring, Andreas E. Kulozik, Jennifer Kriebel, Thomas Meitinger, Konstantin Strauch, Thomas Kirchner, Uta Dirksen, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Gregory T. Armstrong, Smita Bhatia, Leslie L. Robison, Yutaka Yasui, Laura Romero-Pérez, Wolfgang Hartmann, Markus Metzler, W. Ryan Diver, Adriana Lori, Neal D. Freedman, Robert N. Hoover, Lindsay M. Morton, Stephen J. Chanock, Thomas G.P. Grünewald, Olivier Delattre, Mitchell J. Machiela

Am J Hum Genet. 2023 Mar 2; 110(3): 427–441. Published online 2023 Feb 13. doi: 10.1016/j.ajhg.2023.01.017

PMCID:: PMC10027473

Abstract Article PDF–2.4M

Select item 995044716.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 992858417.

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Diana Y. Lu, Jana M. Ellegast, Kenneth N. Ross, Clare F. Malone, Shan Lin, Nathaniel W. Mabe, Neekesh V. Dharia, Ashleigh Meyer, Amy Conway, Angela H. Su, Julia Selich-Anderson, Cenny Taslim, Andrea K. Byrum, Bo Kyung A. Seong, Biniam Adane, Nathanael S. Gray, Miguel N. Rivera, Stephen L. Lessnick, Kimberly Stegmaier

Nat Cell Biol. 2023; 25(2): 285–297. Published online 2023 Jan 19. doi: 10.1038/s41556-022-01059-8

PMCID:: PMC9928584

Abstract Article PDF–11M

Select item 988113618.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 979798819.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255820.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

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