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Select item 109380551.

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant–negative effect

Verónica Palma-Barqueros, Marilena Crescente, María Eugenia de la Morena, Melissa V Chan, Elena Almarza, Nuria Revilla, Natalia Bohdan, Antonia Miñano, José Padilla, Harriet E Allan, Tania Maffucci, Matthew L. Edin, Darryl. C. Zeldin, Cristina Mesa-Nuñez, Carlos Damian, Ana Marín-Quilez, Rocío Benito, Irene Martínez-Martínez, Nuria Bermejo, Ignacio Casas-Aviles, Agustín Rodríguez Alen, José Ramón González-Porras, Jesús María Hernández-Rivas, Vicente Vicente, Javier Corral, María Luisa Lozano, Timothy D. Warner, José María Bastida, José Rivera

Am J Hematol. Author manuscript; available in PMC 2024 Mar 14.

Published in final edited form as: Am J Hematol. 2021 Mar 1; 96(3): E83–E88. Published online 2021 Jan 5. doi: 10.1002/ajh.26076

PMCID:: PMC10938055

Article PDF–671K

Select item 96291212.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 96137003.

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Franziska Nadler, Elena Lavdovskaia, Angelique Krempler, Luis Daniel Cruz-Zaragoza, Sven Dennerlein, Ricarda Richter-Dennerlein

Nat Commun. 2022; 13: 6406. Published online 2022 Oct 27. doi: 10.1038/s41467-022-34088-w

PMCID:: PMC9613700

Abstract Article PDF–1.9M

Select item 92316234.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91434725.

Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study

Kim-Oanh Pham, Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Fumihiko Suzuki, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Hirohito Tsuboi, Thao Thi Thu Nguyen, Yukari Shimizu, Yasuhiro Kambayashi, Masaharu Nakamura, Chie Takazawa, Haruki Nakamura, Toshio Hamagishi, Aki Shibata, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura

Nutrients. 2022 May; 14(10): 2082. Published online 2022 May 16. doi: 10.3390/nu14102082

PMCID:: PMC9143472

Abstract Article PDF–893K

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80941087.

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O’Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner

Haematologica. 2021 May 1; 106(5): 1423–1432. Published online 2020 Apr 16. doi: 10.3324/haematol.2019.235895

PMCID:: PMC8094108

Abstract Article PDF–1.3M

Select item 79983368.

MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women

Hye-Won Cho, Hyun-Seok Jin, Yong-Bin Eom

Genes (Basel) 2021 Mar; 12(3): 378. Published online 2021 Mar 6. doi: 10.3390/genes12030378

PMCID:: PMC7998336

Abstract Article PDF–1.0M

Select item 71801099.

Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1

Michael S. Garshick, Michael Tawil, Tessa J. Barrett, Charissa M. Salud-Gnilo, Michael Eppler, Angela Lee, Jose U. Scher, Andrea L. Neimann, Sanja Jelic, Nehal N. Mehta, Edward A. Fisher, James G. Krueger, Jeffrey S. Berger

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 May; 40(5): 1340–1351. Published online 2020 Mar 5. doi: 10.1161/ATVBAHA.119.314008

PMCID:: PMC7180109

Abstract Article PDF–1.7M

Select item 707165610.

Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas

Nasrin Akbari, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E. Khamseh, Hamideh Akbari, Mitra Nourbakhsh, Alireza Sheikhi, S. Fahimeh Taghavi, Masoumeh Tavakoli-Yaraki

BMC Endocr Disord. 2020; 20: 39. Published online 2020 Mar 14. doi: 10.1186/s12902-020-0515-8

PMCID:: PMC7071656

Abstract Article PDF–1.3M

Select item 685961011.

Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

Lei Zhao, Jinghuan Fang, Muke Zhou, Jie Zhou, Lihua Yu, Ning Chen, Li He

BMC Neurol. 2019; 19: 291. Published online 2019 Nov 17. doi: 10.1186/s12883-019-1505-1

PMCID:: PMC6859610

Abstract Article PDF–569K

Select item 637516012.

Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling

Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang, Yongsheng Zhou

Stem Cell Res Ther. 2019; 10: 57. Published online 2019 Feb 13. doi: 10.1186/s13287-019-1167-3

PMCID:: PMC6375160

Abstract Article PDF–4.0M

Select item 582692613.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 576541714.

Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype

Michael J. O’Sullivan, Elizabeth Gabriel, Alice Panariti, Chan Y. Park, Gijs Ijpma, Jeffrey J. Fredberg, Anne-Marie Lauzon, James G. Martin

Am J Respir Cell Mol Biol. 2017 Dec; 57(6): 683–691. doi: 10.1165/rcmb.2016-0427OC

PMCID:: PMC5765417

Abstract Article PDF–860K

Select item 554345715.

Extracellular histones disarrange vasoactive mediators release through a COX‐NOS interaction in human endothelial cells

Daniel Pérez‐Cremades, Carlos Bueno‐Betí, José Luis García‐Giménez, José Santiago Ibañez‐Cabellos, Carlos Hermenegildo, Federico V. Pallardó, Susana Novella

J Cell Mol Med. 2017 Aug; 21(8): 1584–1592. Published online 2017 Feb 28. doi: 10.1111/jcmm.13088

PMCID:: PMC5543457

Abstract Article PDF–521K

Select item 550129116.

Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants

D. NANCE, R. A. CAMPBELL, J. W. ROWLEY, J. M. DOWNIE, L. B. JORDE, W. H. KAHR, S. A. MEREBY, N. D. TOLLEY, G. A. ZIMMERMAN, A. S. WEYRICH, M. T. RONDINA

J Thromb Haemost. Author manuscript; available in PMC 2017 Jul 7.

Published in final edited form as: J Thromb Haemost. 2016 Nov; 14(11): 2230–2240. Published online 2016 Oct 20. doi: 10.1111/jth.13500

PMCID:: PMC5501291

Abstract Article PDF–685K

Select item 506129317.

Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E₂ in Normal Human Colon Tissue

ElKhansa Sidahmed, Ananda Sen, Jianwei Ren, Arsh Patel, D. Kim Turgeon, Mack T. Ruffin, Dean Brenner, Zora Djuric

Nutr Cancer. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Nutr Cancer. 2016 Oct; 68(7): 1192–1201. Published online 2016 Aug 22. doi: 10.1080/01635581.2016.1213866

PMCID:: PMC5061293

Abstract Article PDF–682K

Select item 504075618.

Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities

Miao Liu, Tarek Boussetta, Karama Makni-Maalej, Michèle Fay, Fathi Driss, Jamel El-Benna, Michel Lagarde, Michel Guichardant

Lipids. Author manuscript;

Published in final edited form as: Lipids. 2014 Jan; 49(1): 49–57. Published online 2013 Nov 20. doi: 10.1007/s11745-013-3863-6

PMCID:: PMC5040756

Abstract Article

Select item 491943319.

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A₃, a Neutrophil-activating Eicosanoid

Christine Hinz, Maceler Aldrovandi, Charis Uhlson, Lawrence J. Marnett, Hilary J. Longhurst, Timothy D. Warner, Saydul Alam, David A. Slatter, Sarah N. Lauder, Keith Allen-Redpath, Peter W. Collins, Robert C. Murphy, Christopher P. Thomas, Valerie B. O'Donnell

J Biol Chem. 2016 Jun 24; 291(26): 13448–13464. Published online 2016 Apr 22. doi: 10.1074/jbc.M115.700609

PMCID:: PMC4919433

Abstract Article PDF–3.4M

Select item 482920320.

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants

Digna R. Velez, Stephen Fortunato, Poul Thorsen, Salvatore J. Lombardi, Scott M. Williams, Ramkumar Menon

Am J Obstet Gynecol. Author manuscript; available in PMC 2016 Apr 12.

Published in final edited form as: Am J Obstet Gynecol. 2009 Feb; 200(2): 209.e1–209.27. Published online 2008 Nov 18. doi: 10.1016/j.ajog.2008.08.051

PMCID:: PMC4829203

Abstract Article PDF–164K

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PMC Links for GEO Profiles (Select 12584254) (90)
PMC
Homo sapiens prostaglandin-endoperoxide synthase 1 (PTGS1), transcript variant 1...
Homo sapiens prostaglandin-endoperoxide synthase 1 (PTGS1), transcript variant 1, mRNA
gi|403310636|ref|NM_000962.3|

Nucleotide
Mus musculus strain C57BL/6J chromosome 17, GRCm39
Mus musculus strain C57BL/6J chromosome 17, GRCm39
gi|1877089952|gnl|ASM:GCF_000000055 ef|NC_000083.7||gpp|GPC_000007829.1||gnl|NCBI_GENOMES|85

Nucleotide
Trem2 triggering receptor expressed on myeloid cells 2 [Mus musculus]
Trem2 triggering receptor expressed on myeloid cells 2 [Mus musculus]
Gene ID:83433

Gene
83433[uid] AND (alive[prop]) (1)
Gene

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